Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

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Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Pancreatitis D010195 10 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Hypersensitivity D006967 22 associated lipids
Osteosarcoma D012516 50 associated lipids
Rhinitis D012220 10 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Melanoma D008545 69 associated lipids
Asthma D001249 52 associated lipids
Weight Gain D015430 101 associated lipids
Brain Diseases D001927 27 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Matsumoto M and Miwa M Platelet-activating factor-binding protein in human serum. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004155
Terashita Z et al. Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3004156
Michel L and Dubertret L A simple method for studying chemotaxis, vascular permeability and histological modifications induced by mediators of inflammation in vivo in man. 1985 Br. J. Dermatol. pmid:2990519
Morris HG Mechanisms of glucocorticoid action in pulmonary disease. 1985 Chest pmid:2410202
Shukla SD Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin. 1985 Arch. Biochem. Biophys. pmid:3875314
Sybertz EJ et al. Cardiac, coronary and peripheral vascular effects of acetyl glyceryl ether phosphoryl choline in the anesthetized dog. 1985 J. Pharmacol. Exp. Ther. pmid:3917504
Harlan JM Leukocyte-endothelial interactions. 1985 Blood pmid:3918593
McKean ML and Silver MJ Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. 1985 Biochem. J. pmid:3919710
Bruynzeel PL et al. Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan. 1985 FEBS Lett. pmid:2995125
Pfeilschifter J et al. Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. 1985 Biochem. Biophys. Res. Commun. pmid:2985064
Moore TL and Weiss TD Mediators of inflammation. 1985 Semin. Arthritis Rheum. pmid:3936177
Hwang SB et al. Specific binding sites for platelet activating factor in human lung tissues. 1985 Biochem. Biophys. Res. Commun. pmid:2986633
Archer CB et al. Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. 1985 Agents Actions pmid:3923788
Sturk A et al. Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway. 1985 Thromb. Res. pmid:2934863
Terashita Z et al. Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. 1985 Biochem. Pharmacol. pmid:2986648
Morley J et al. Pharmacology of the late response to allergen and its relevance to asthma prophylaxis. 1985 Int. Arch. Allergy Appl. Immunol. pmid:3924841
Hwang SB et al. Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. 1985 Lab. Invest. pmid:3925239
Vanderwel M and Haslam RJ Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. 1985 J. Clin. Invest. pmid:2991338
Naccache PH et al. Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. 1985 Biochem. Biophys. Res. Commun. pmid:2992480
MacIntyre DE et al. Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. 1985 FEBS Lett. pmid:2993027
Bourgain RH et al. The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. 1985 Prostaglandins pmid:3931178
Hayashi H et al. Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. 1985 J. Biochem. pmid:2993272
Avdonin PV et al. Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). 1985 Biochem. Biophys. Res. Commun. pmid:2994653
Ribbes G et al. Evidence that biosynthesis of platelet-activating factor (paf-acether) by human neutrophils occurs in an intracellular membrane. 1985 FEBS Lett. pmid:3932094
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
García-Sáinz JA and Hernández-Sotomayor SM Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. 1985 Biochem. Biophys. Res. Commun. pmid:3933497
Zukowska-Grojec Z et al. The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. 1985 Clin Exp Hypertens A pmid:2994912
Shen TY et al. The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. 1985 Int J Tissue React pmid:2997065
Sánchez Crespo M et al. Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. 1985 Int J Tissue React pmid:2997066
Barnes PJ Mediators and asthma. 1985 Br J Hosp Med pmid:3936563
Proll MA et al. Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. 1985 Mol. Pharmacol. pmid:2997592
MacIntyre DE et al. Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. 1985 Nouv Rev Fr Hematol pmid:2997706
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Hemmendinger S et al. [Physiology of the interactions of blood and the blood vessel wall. Role of pharmacologically active lipids]. 1985 Arch Mal Coeur Vaiss pmid:3938941
Hwang SB et al. trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. 1985 J. Biol. Chem. pmid:2999126
Iñarrea P et al. Synthesis of PAF-acether and blood volume changes in gram-negative sepsis. 1985 Immunopharmacology pmid:3886598
Lellouch-Tubiana A et al. Ultrastructural evidence for extravascular platelet recruitment in the lung upon intravenous injection of platelet-activating factor (PAF-acether) to guinea-pigs. 1985 Br J Exp Pathol pmid:3890915
Weber N and Mangold HK Semi-synthetic preparation of 1-O-[1'-14C]hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) using plant cell cultures. 1985 J. Lipid Res. pmid:3891896
Hanahan DJ and Weintraub ST Platelet-activating factor isolation, identification, and assay. 1985 Methods Biochem Anal pmid:3894881
Lad PM et al. Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. 1985 Biochem. Biophys. Res. Commun. pmid:2990462
Hayashi H et al. Macrophage activation by PAF incorporated into dipalmitoylphosphatidylcholine-cholesterol liposomes. 1985 J. Biochem. pmid:3839790
Tokumura A et al. Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation. 1985 J. Biol. Chem. pmid:3840169
Sánchez-Crespo M et al. Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether. 1985 Immunopharmacology pmid:3840779
Billah MM et al. Lipoxygenase products of arachidonic acid modulate biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human neutrophils via phospholipase A2. 1985 J. Biol. Chem. pmid:3922982
Foa R et al. Release of platelet-activating factor in human leukemia. 1985 Cancer Res. pmid:3861246
Otsuka A et al. Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. 1985 Prostaglandins Leukot Med pmid:3862138
Hallam TJ et al. Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. 1985 Adv. Exp. Med. Biol. pmid:3010663
Gerrard JM et al. Platelet protein phosphorylation. 1985 Adv. Exp. Med. Biol. pmid:3010667
Haslam RJ et al. Receptor-effector coupling in platelets: roles of guanine nucleotides. 1985 Adv. Exp. Med. Biol. pmid:3010668
Teng CM et al. Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. 1985 Biochim. Biophys. Acta pmid:3926005
Ostermann G et al. Platelet-stimulating and membranolytic properties of racemic PAF-acether and analogues. 1985 Biomed. Biochim. Acta pmid:4004829
Touqui L et al. Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. 1985 Biochem. J. pmid:4052028
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Detsouli A et al. Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. 1985 Br. J. Pharmacol. pmid:4005486
Korth R et al. Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin. 1985 Chem. Phys. Lipids pmid:4006034
Shigenobu K et al. Platelet activating factor analogues: lack of correlation between their activities to produce hypotension and endothelium-mediated vasodilation. 1985 J. Pharmacobio-dyn. pmid:4009403
Apprill P et al. Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. 1985 Circulation pmid:2988822
Saeki S et al. Effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) on cardiac function in perfused guinea-pig heart. 1985 Life Sci. pmid:4010479
Zimmerman GA et al. Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. 1985 Circulation pmid:3928193
Gerdin B et al. Permeability-increasing ability of PAF-acether in rat skin. 1985 Inflammation pmid:3980073
Emeis JJ and Kluft C PAF-acether-induced release of tissue-type plasminogen activator from vessel walls. 1985 Blood pmid:3924144
Yousufzai SY and Abdel-Latif AA Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. 1985 Biochem. J. pmid:3927898
Benveniste J and Chignard M A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? 1985 Circulation pmid:3928192
MacIntyre DE et al. Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. 1985 FEBS Lett. pmid:2981715
Cordón-Cardó C [The barley cell or mastocyte: cellular and molecular biology]. 1985 Med Clin (Barc) pmid:2580196
Klöcking HP et al. Release of tissue-type plasminogen activator by platelet-activating factor. 1985 Thromb. Res. pmid:4040278
McManus LM and Pinckard RN Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. 1985 Am. J. Pathol. pmid:4050977
Disselnkötter H et al. [Synthesis of phosphono analogs of 2-O-acetyl-1-O-hexadecyl(octadecyl)-sn-3-glycerylphosphorylcholine (platelet-activating factor)]. 1985 Arch. Pharm. (Weinheim) pmid:4051690
Ogunbiyi PO and Eyre P Pharmacological studies of pulmonary anaphylaxis in vitro: a review. 1985 Agents Actions pmid:2420161
Robinson M and Snyder F Metabolism of platelet-activating factor by rat alveolar macrophages: lyso-PAF as an obligatory intermediate in the formation of alkylarachidonoyl glycerophosphocholine species. 1985 Biochim. Biophys. Acta pmid:4052436
Kozlov VK et al. [Characteristics of the activation of rabbit platelets induced by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activation factor)]. 1985 Biull Eksp Biol Med pmid:4052603
Page CP et al. Properties of PAF-acether appropriate to a mediator of the inflammatory aspects of asthma. 1985 Int J Tissue React pmid:4055261
Wardlow ML Rapid isocratic procedure for the separation of platelet-activating factor from phospholipids in human saliva by high-performance liquid chromatography. 1985 J. Chromatogr. pmid:4055961
Hubbard JW et al. Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats. 1985 Res. Commun. Chem. Pathol. Pharmacol. pmid:4059660
Imbs AB et al. [Synthesis of a fluorescently-labeled platelet activating factor]. 1985 Bioorg. Khim. pmid:4062993
Tokumura A et al. Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. 1985 J. Chromatogr. pmid:4066848
Meloni Bruneri LH and Barbieri D [Platelet aggregation after the reduction of nitro-blue tetrazolium by eosinophils]. 1985 Sangre (Barc) pmid:4071355
Söling HD et al. Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. 1985 Adv. Enzyme Regul. pmid:4072796
Mushayakarara EC and Mantsch HH Thermotropic phase behavior of the platelet-activating factor: an infrared spectroscopic study. 1985 Can. J. Biochem. Cell Biol. pmid:4075223
Zimmerman GA et al. Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitro. 1985 J. Clin. Invest. pmid:4077977
Young JM et al. Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse. 1985 Prostaglandins pmid:4081060
Vanhoutte PM and Houston DS Platelets, endothelium, and vasospasm. 1985 Circulation pmid:3861273
Spicer BA et al. An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. 1985 Agents Actions pmid:4003197
Sandler RM et al. Heparin-induced thrombocytopenia and thrombosis: detection and specificity of a platelet-aggregating IgG. 1985 Am. J. Clin. Pathol. pmid:4003343
Tencé M et al. Ether-phospholipid composition in neutrophils and platelets. 1985 Thromb. Res. pmid:4024039
Tan EL and Snyder F Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by capillary endothelial cells isolated from rat epididymal adipose tissue. 1985 Thromb. Res. pmid:4024051
Weisman SM et al. Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. 1985 J. Pharmacol. Exp. Ther. pmid:3862805
Morley J et al. PAF and airway hyperreactivity. 1985 Lancet pmid:2863479
Morley J et al. Platelets in asthma. 1985 Lancet pmid:2863708
Cox CP Activation of washed chicken thrombocytes by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycero-3-phosphorylcholine (platelet-activating factor). 1985 Comp Biochem Physiol A Comp Physiol pmid:2864195
Peach MJ et al. Mechanisms of endothelium-dependent vascular smooth muscle relaxation. 1985 Biochem. Pharmacol. pmid:2988558
Orlov SM et al. [Histamine release from human leukocytes after treatment with 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) and its structural analogs]. 1985 Biokhimiia pmid:2408682
Hallam TJ and Rink TJ Agonists stimulate divalent cation channels in the plasma membrane of human platelets. 1985 FEBS Lett. pmid:2408921
O'Neill C et al. Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. 1985 Ann. N. Y. Acad. Sci. pmid:2409860
Sage SO and Rink TJ Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. 1985 FEBS Lett. pmid:2410292
Grandel KE et al. Association of platelet-activating factor with primary acquired cold urticaria. 1985 N. Engl. J. Med. pmid:2410790
Bussolino F et al. Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. 1985 J. Immunol. pmid:2411812
Johnson HM and Torres BA Mechanism of calcium ionophore A23187-induced priming of bone marrow-derived macrophages for tumor cell killing: relationship to priming by interferon. 1985 Proc. Natl. Acad. Sci. U.S.A. pmid:2412225
Pannocchia A and Hardisty RM Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. 1985 Biochem. Biophys. Res. Commun. pmid:2983714
Nishihira J et al. Purification and characterization of the specific binding protein for platelet activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from human platelets. 1985 Tohoku J. Exp. Med. pmid:3001971