Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Corneal Neovascularization D016510 8 associated lipids
Lupus Nephritis D008181 8 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Leukopenia D007970 9 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Pancreatitis D010195 10 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Infertility, Male D007248 11 associated lipids
Migraine Disorders D008881 11 associated lipids
Shock D012769 11 associated lipids
Meningioma D008579 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Shock, Septic D012772 11 associated lipids
Venous Thrombosis D020246 11 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Fetal Weight D020567 12 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Death, Sudden D003645 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Amnesia D000647 12 associated lipids
Hypertension, Portal D006975 12 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Heart Arrest D006323 13 associated lipids
Osteoarthritis, Knee D020370 13 associated lipids
Hypercalcemia D006934 13 associated lipids
Polycythemia Vera D011087 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Stomatitis D013280 14 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Neutropenia D009503 15 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Encephalitis D004660 15 associated lipids
Hemorrhage D006470 15 associated lipids
Staphylococcal Infections D013203 15 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Diez-Fraile A et al. Effect of proinflammatory mediators and glucocorticoids on L-selectin expression in peripheral blood neutrophils from dairy cows in various stages of lactation. 2004 Am. J. Vet. Res. pmid:15524330
Menzies-Gow NJ et al. Roles of thromboxane A2 and 5-hydroxytryptamine in endotoxin-induced digital vasoconstriction in horses. 2008 Am. J. Vet. Res. pmid:18241016
Kingston JK et al. Effects of formaldehyde fixation on equine platelets using flow cytometric methods to evaluate markers of platelet activation. 2002 Am. J. Vet. Res. pmid:12061530
Wilson DV et al. Cardiovascular responses to exogenous platelet-activating factor (PAF) in anesthetized ponies, and the effects of a PAF antagonist, WEB 2086. 1993 Am. J. Vet. Res. pmid:8430938
Weiss DJ and Evanson OA Detection of activated platelets and platelet-leukocyte aggregates in horses. 1997 Am. J. Vet. Res. pmid:9256963
Tsuchiya R et al. Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. 1999 Am. J. Vet. Res. pmid:10048555
Watanabe M et al. Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. 2016 Am. J. Vet. Res. pmid:27580108
Lee EK and Kehrli ME Expression of adhesion molecules on neutrophils of periparturient cows and neonatal calves. 1998 Am. J. Vet. Res. pmid:9442240
Tan WC and Bethel RA The effect of platelet activating factor antagonist on ozone-induced airway inflammation and bronchial hyperresponsiveness in guinea pigs. 1992 Am. Rev. Respir. Dis. pmid:1416419
Hamasaki Y et al. Platelet-activating factor raises airway and vascular pressures and induces edema in lungs perfused with platelet-free solution. 1984 Am. Rev. Respir. Dis. pmid:6547031
Stengel PW et al. Inhaled A23187 produces a preferential sensitization to substance P. 1993 Am. Rev. Respir. Dis. pmid:7678372
Daniel EE and O'Byrne P Effect of inflammatory mediators on airway nerves and muscle. 1991 Am. Rev. Respir. Dis. pmid:2003686
Meade CJ and Heuer H PAF antagonism as an approach to the treatment of airway hyperreactivity. 1991 Am. Rev. Respir. Dis. pmid:2003696
Rylander R and Beijer L Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3541718
Smith LJ The role of platelet-activating factor in asthma. 1991 Am. Rev. Respir. Dis. pmid:2018248
Perretti F and Manzini S Activation of capsaicin-sensitive sensory fibers modulates PAF-induced bronchial hyperresponsiveness in anesthetized guinea pigs. 1993 Am. Rev. Respir. Dis. pmid:7692777
McMurtry IF and Morris KG Platelet-activating factor causes pulmonary vasodilation in the rat. 1986 Am. Rev. Respir. Dis. pmid:3094417
Christman BW et al. Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. 1987 Am. Rev. Respir. Dis. pmid:3592402
Benveniste J A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? 1987 Am. Rev. Respir. Dis. pmid:3592414
Halonen M et al. Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. 1981 Am. Rev. Respir. Dis. pmid:7294504
Ohar JA et al. A rabbit model of pulmonary hypertension induced by the synthetic platelet-activating factor acetylglyceryl ether phosphorylcholine. 1990 Am. Rev. Respir. Dis. pmid:2297169
Lohman I and Halonen M Effects of the PAF antagonist WEB 2086 on PAF-induced physiologic alterations and on IgE anaphylaxis in the rabbit. 1990 Am. Rev. Respir. Dis. pmid:2382903
Stenmark KR et al. Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. 1987 Am. Rev. Respir. Dis. pmid:3631747
Barer GR et al. Reactivity and site of vasomotion in pulmonary vessels of chronically hypoxic rats: relation to structural changes. 1989 Am. Rev. Respir. Dis. pmid:2817616
Oda M et al. The presence of platelet-activating factor associated with eosinophil and/or neutrophil accumulations in the pleural fluids. 1990 Am. Rev. Respir. Dis. pmid:2350088
Pretolani M et al. Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. 1988 Am. Rev. Respir. Dis. pmid:3202509
Schellenberg RR Airway responses to platelet-activating factor. 1987 Am. Rev. Respir. Dis. pmid:3310779
Miadonna A et al. Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. 1989 Am. Rev. Respir. Dis. pmid:2546468
Pretolani M et al. Protection by nedocromil sodium of active immunization-induced bronchopulmonary alterations in the guinea pig. 1990 Am. Rev. Respir. Dis. pmid:2160213
Rubin AH et al. The bronchoconstrictor properties of platelet-activating factor in humans. 1987 Am. Rev. Respir. Dis. pmid:3314611
Schleimer RP et al. Characterization of inflammatory mediator release from purified human lung mast cells. 1986 Am. Rev. Respir. Dis. pmid:3485946
Lantz RC et al. The role of platelet-activating factor in the pulmonary response to inhaled bacterial endotoxin. 1991 Am. Rev. Respir. Dis. pmid:2064124
Zimmerman GA et al. Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. 1987 Am. Rev. Respir. Dis. pmid:3300444
Murphy RC and Clay KL Measurement of platelet-activating factor by physicochemical technique s. 1987 Am. Rev. Respir. Dis. pmid:3300445
Page CP Mechanisms of hyperresponsiveness: platelet-activating factor. 1992 Am. Rev. Respir. Dis. pmid:1734810
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Scappaticci E et al. Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. 1992 Am. Rev. Respir. Dis. pmid:1336939
Tokuyama K et al. Mechanism of airway narrowing caused by inhaled platelet-activating factor. Role of airway microvascular leakage. 1991 Am. Rev. Respir. Dis. pmid:2048823
Boschetto P et al. Effect of antiasthma drugs on microvascular leakage in guinea pig airways. 1989 Am. Rev. Respir. Dis. pmid:2563319
Lansing MW et al. Lipid mediators contribute to oxygen-radical-induced airway responses in sheep. 1991 Am. Rev. Respir. Dis. pmid:1741541
Ohar JA et al. Platelet-activating factor induces selective pulmonary arterial hyperreactivity in isolated perfused rabbit lungs. 1993 Am. Rev. Respir. Dis. pmid:8317792
Smith LJ et al. Effect of leukotriene D4 and platelet-activating factor on human alveolar macrophage eicosanoid and PAF synthesis. 1993 Am. Rev. Respir. Dis. pmid:8368641
Watson JW et al. IgG1-mediated acute pulmonary hypersensitivity response in the guinea pig. Involvement of specific lipid mediators. 1990 Am. Rev. Respir. Dis. pmid:2240832
Tocker JE et al. Phospholipase A2-induced pulmonary and hemodynamic responses in the guinea pig. Effects of enzyme inhibitors and mediators antagonists. 1990 Am. Rev. Respir. Dis. pmid:2240843
Kidney JC et al. Inhibition of platelet-activating factor-induced bronchoconstriction by the leukotriene D4 receptor antagonist ICI 204,219. 1993 Am. Rev. Respir. Dis. pmid:8420421
Lellouch-Tubiana A et al. Eosinophil recruitment into guinea pig lungs after PAF-acether and allergen administration. Modulation by prostacyclin, platelet depletion, and selective antagonists. 1988 Am. Rev. Respir. Dis. pmid:3281530
Kuitert LM et al. Effect of the platelet-activating factor antagonist UK-74,505 on the early and late response to allergen. 1993 Am. Rev. Respir. Dis. pmid:8420437
Wardlaw AJ et al. Effects of inhaled PAF in humans on circulating and bronchoalveolar lavage fluid neutrophils. Relationship to bronchoconstriction and changes in airway responsiveness. 1990 Am. Rev. Respir. Dis. pmid:2405759
Robertson DN et al. The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. 1988 Am. Rev. Respir. Dis. pmid:2849329
Tam FW et al. Inhaled platelet-activating factor causes pulmonary neutrophil sequestration in normal humans. 1992 Am. Rev. Respir. Dis. pmid:1416388