Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Johnson M et al. | Levocetirizine and rupatadine in chronic idiopathic urticaria. | 2015 | Int. J. Dermatol. | pmid:25521304 |
| Kim H et al. | Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. | 2015 | J. Bone Miner. Metab. | pmid:25501698 |
| Mullol J et al. | Update on rupatadine in the management of allergic disorders. | 2015 | Allergy | pmid:25491409 |
| Zhao YM and Maimone TJ | Short, enantioselective total synthesis of chatancin. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470723 |
| Kattan JD and Sicherer SH | Optimizing the diagnosis of food allergy. | 2015 | Immunol Allergy Clin North Am | pmid:25459577 |
| Vlachogianni IC et al. | Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26358846 |
| Sato A et al. | Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. | 2015 | Peptides | pmid:26348270 |
| Damiani E et al. | Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. | 2015 | J. Invest. Dermatol. | pmid:26316070 |
| Starossom SC et al. | Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. | 2015 | Circ. Res. | pmid:26294656 |
| Kulinski JM et al. | Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. | 2016 | Eur. J. Pharmacol. | pmid:25941085 |
| Wang M et al. | The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats. | 2016 | Biol. Pharm. Bull. | pmid:27040628 |
| Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
| Liu R et al. | Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs. | 2016 | Burns | pmid:27130433 |
| Grambow E et al. | Differential effects of endogenous, phyto and synthetic cannabinoids on thrombogenesis and platelet activity. | 2016 | Biofactors | pmid:27151562 |
| Eleftheriou K et al. | Comparative Experimental and Computational Study of Monoalkyl Chain Phosphatidylcholine-Containing Thermoresponsive Liposomes. | 2016 | J Phys Chem B | pmid:27280363 |
| Megson IL et al. | Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy? | 2016 | Food Funct | pmid:27109548 |
| Farbman KS and Michelson KA | Anaphylaxis in children. | 2016 | Curr. Opin. Pediatr. | pmid:26963947 |
| Sahu RP et al. | Radiation therapy generates platelet-activating factor agonists. | 2016 | Oncotarget | pmid:26959112 |
| Müllers SM et al. | Altered Platelet Function in Intrauterine Growth Restriction: A Cause or a Consequence of Uteroplacental Disease? | 2016 | Am J Perinatol | pmid:26906182 |
| Nimjee SM et al. | Translation and Clinical Development of Antithrombotic Aptamers. | 2016 | Nucleic Acid Ther | pmid:26882082 |
| Moschos MM et al. | Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study. | 2016 | Drug Des Devel Ther | pmid:27994439 |
| Vadas P | The platelet-activating factor pathway in food allergy and anaphylaxis. | 2016 | Ann. Allergy Asthma Immunol. | pmid:27788869 |
| Pike DP et al. | Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode. | 2016 | Lipids | pmid:27757707 |
| Täubel J et al. | Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. | 2016 | PLoS ONE | pmid:27632557 |
| Hoenderdos K et al. | Hypoxia upregulates neutrophil degranulation and potential for tissue injury. | 2016 | Thorax | pmid:27581620 |
| Watanabe M et al. | Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | 2016 | Am. J. Vet. Res. | pmid:27580108 |
| González-Núñez V et al. | Rupatadine: global safety evaluation in allergic rhinitis and urticaria. | 2016 | Expert Opin Drug Saf | pmid:27500993 |
| Kamaladasa A et al. | Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. | 2016 | Antiviral Res. | pmid:27476044 |
| Schauberger E et al. | Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets. | 2016 | Curr Allergy Asthma Rep | pmid:27333777 |
| Wang JM and Chen J | Damage of vascular endothelial barrier induced by explosive blast and its clinical significance. | 2016 | Chin. J. Traumatol. | pmid:27321288 |
| Nel JG et al. | Pneumolysin Mediates Platelet Activation In Vitro. | 2016 | Lung | pmid:27192991 |
| Silva-Herdade AS et al. | Erythrocyte deformability - A partner of the inflammatory response. | 2016 | Microvasc. Res. | pmid:27142964 |
| Wang M et al. | The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. | 2016 | Life Sci. | pmid:26808090 |
| Quinn RA et al. | Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence. | 2016 | Proc. Biol. Sci. | pmid:27122568 |
| Lecewicz M et al. | Effects of the platelet-activating factor (PAF) on selected quality parameters of cryopreserved bull semen (AI) with reduced sperm motility. | 2016 | Pol J Vet Sci | pmid:27096799 |
| Damiani E and Ullrich SE | Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer. | 2016 | Prog. Lipid Res. | pmid:27073146 |
| Jacob SP et al. | Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance. | 2016 | PLoS ONE | pmid:27064683 |
| Eser A et al. | Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients. | 2016 | Taiwan J Obstet Gynecol | pmid:26927250 |
| Guequén A et al. | S-nitrosylation regulates VE-cadherin phosphorylation and internalization in microvascular permeability. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26921435 |
| Bihl JC et al. | UVB Generates Microvesicle Particle Release in Part Due to Platelet-activating Factor Signaling. | 2016 | Photochem. Photobiol. | pmid:26876152 |
| Reiner B et al. | Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling. | 2016 | Neurosci. Lett. | pmid:26808643 |
| Unsal E et al. | Effects of pentoxifylline and platelet activating factor on sperm DNA damage. | 2016 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:26748389 |
| Park JH et al. | Glucosamine suppresses platelet-activating factor-induced activation of microglia through inhibition of store-operated calcium influx. | 2016 | Environ. Toxicol. Pharmacol. | pmid:26745504 |
| RodrÃguez M et al. | Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells. | 2016 | Biochem. Pharmacol. | pmid:26673542 |
| Aquino EN et al. | Proteomic Analysis of Neutrophil Priming by PAF. | 2016 | Protein Pept. Lett. | pmid:26631175 |
| Anandi VL et al. | Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures. | 2016 | Oncol. Rep. | pmid:26531049 |
| Wright NR et al. | Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. | 2016 | Am. J. Med. | pmid:26524710 |
| Kim HK et al. | Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation. | 2016 | Int. Arch. Allergy Immunol. | pmid:27838690 |
| Wang Y et al. | Attenuated Reactive Gliosis and Enhanced Functional Recovery Following Spinal Cord Injury in Null Mutant Mice of Platelet-Activating Factor Receptor. | 2016 | Mol. Neurobiol. | pmid:26084439 |
| Kelly AM et al. | The effect of variation in donor platelet function on transfusion outcome: a semirandomized controlled trial. | 2017 | Blood | pmid:28487294 |