Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hill LL et al. | Neutrophils and neutrophil products do not mediate pulmonary hemodynamic effects of endotoxin on oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742386 |
Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
Despotis GJ et al. | Evaluation of a new point-of-care test that measures PAF-mediated acceleration of coagulation in cardiac surgical patients. | 1996 | Anesthesiology | pmid:8968178 |
Pierce PA et al. | Halothane selectively inhibits bradykinin-induced synovial plasma extravasation. | 1995 | Anesthesiology | pmid:7661358 |
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Hollmann MW et al. | Local anesthetic effects on priming and activation of human neutrophils. | 2001 | Anesthesiology | pmid:11465548 |
Hofer RE et al. | The effect of a platelet activating factor antagonist (BN 52021) on neurologic outcome and histopathology in a canine model of complete cerebral ischemia. | 1993 | Anesthesiology | pmid:8342844 |
Ereth MH et al. | The relation between the platelet-activated clotting test (HemoSTATUS) and blood loss after cardiopulmonary bypass. | 1998 | Anesthesiology | pmid:9579505 |
Hollmann MW et al. | Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. | 2004 | Anesthesiology | pmid:15087620 |
Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
Zhao YM and Maimone TJ | Short, enantioselective total synthesis of chatancin. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470723 |
Kudriavtseva IuA et al. | [Sorption and contact-activating properties of the <biograft-artery> anastomosis zone: effect of suture material (communication II)]. | 2008 | Angiol Sosud Khir | pmid:19156039 |
Tsantila N et al. | In vitro and in vivo effects of statins on platelet-activating factor and its metabolism. | 2011 | Angiology | pmid:20805097 |
Detopoulou P et al. | Baseline and 6-Week follow-up levels of PAF and activity of its metabolic enzymes in patients with heart failure and healthy volunteers--a pilot study. | 2013 | Angiology | pmid:23000600 |
Tsoupras AB et al. | Platelet-activating factor and its basic metabolic enzymes in blood of naive HIV-infected patients. | 2012 | Angiology | pmid:21948973 |
Gupta JB et al. | Platelet-activating-factor-induced changes in cardiovascular function and oxyradical status of myocardium in presence of the PAF antagonist CV-6209. | 1994 | Angiology | pmid:8285381 |
Smith J et al. | Differences in gene density on chicken macrochromosomes and microchromosomes. | 2000 | Anim. Genet. | pmid:10782207 |
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Wang S and Townley RG | Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes. | 1992 | Ann Allergy | pmid:1324627 |
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Doly M and Oustrin J | [Suppression of platelet activating factor effects (PAF) on the retina by G-proteins inhibitors]. | 1996 | Ann Pharm Fr | pmid:8734330 |
Shindo K | Inhibitory effect of azelastine on platelet activating factor-like activity in eosinophils in asthmatic patients. | 1995 | Ann Pharmacother | pmid:7606085 |
González-Fajardo JA et al. | Protective effect of a platelet-activating factor antagonist (WEB-2086) in postischemic renal failure. | 1996 | Ann Vasc Surg | pmid:8688291 |
Tanaka R et al. | Genetics of immunoglobulin A nephropathy. | 2000 | Ann. Acad. Med. Singap. | pmid:10976391 |
Casale TB et al. | Eosinophils isolated by magnetic cell sorting respond poorly to lipid chemoattractants. | 1999 | Ann. Allergy Asthma Immunol. | pmid:10480585 |
Tokuyama K et al. | Effect of procaterol, a beta 2-adrenoceptor agonist, on skin whealing response caused by inflammatory mediators in asthmatic children. | 1995 | Ann. Allergy Asthma Immunol. | pmid:7544228 |
Chihara J et al. | Inhibitory effect of ibudilast (KC-404) on the expression of the beta2 integrin family on an eosinophilic cell line (EoL-1). | 1998 | Ann. Allergy Asthma Immunol. | pmid:9860039 |
Fujiu T et al. | Cellular adhesion is required for effector functions of human eosinophils via G-protein coupled receptors. | 2002 | Ann. Allergy Asthma Immunol. | pmid:12141728 |
Seguchi M and Nakajima S | Induction of ICAM-1 expression on the eosinophilic leukemia cell line-3 (EoL-3) by platelet-activating factor and platelet factor 4. | 1995 | Ann. Allergy Asthma Immunol. | pmid:7889382 |
Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
Vadas P | The platelet-activating factor pathway in food allergy and anaphylaxis. | 2016 | Ann. Allergy Asthma Immunol. | pmid:27788869 |
Metz M et al. | Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. | 2010 | Ann. Allergy Asthma Immunol. | pmid:20143651 |
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Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
Grino JM | BN 52021: a platelet activating factor antagonist for preventing post-transplant renal failure. A double-blind, randomized study. The BN 52021 Study Group in Renal Transplantation. | 1994 | Ann. Intern. Med. | pmid:8042824 |
Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
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Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |
He J et al. | Micellar electrokinetic capillary chromatographic analysis of platelet activating factor in human blood by indirect ultraviolet detection. | 1996 | Ann. Ist. Super. Sanita | pmid:9028060 |
Bussolino F | [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. | 1988 | Ann. Ist. Super. Sanita | pmid:3218801 |