Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Loucks EB et al. | Platelet-activating factor antagonism: a new concept in the management of regional myocardial ischemia-reperfusion injury. | 1997 Nov-Dec | J Invest Surg | pmid:9654389 |
| Itadani K et al. | Inhibition of Na+,K(+)-ATPase by platelet-activating factor in dog submandibular glands. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653774 |
| Ginkgo biloba for dementia. | 1998 | Med Lett Drugs Ther | pmid:9653424 | |
| Küçükhüseyin C et al. | On the mechanisms of adenosine induced pulmonary vasoconstriction in rats. | 1997 | J Basic Clin Physiol Pharmacol | pmid:9651801 |
| Roudebush WE and Mathur RS | Presence of platelet-activating factor in squirrel monkey (Saimiri boliviensis) spermatozoa: seasonal differences. | 1998 | Am. J. Primatol. | pmid:9651652 |
| Perry SW et al. | Platelet-activating factor receptor activation. An initiator step in HIV-1 neuropathogenesis. | 1998 | J. Biol. Chem. | pmid:9651362 |
| Minamiya Y et al. | Platelet-activating factor mediates intercellular adhesion molecule-1-dependent radical production in the nonhypoxic ischemia rat lung. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9651191 |
| Han BH et al. | In vitro platelet-activating factor receptor binding inhibitory activity of pinusolide derivatives: a structure-activity study. | 1998 | J. Med. Chem. | pmid:9651167 |
| Shindo K et al. | Platelet-activating factor increases leukotriene B4 release in stimulated alveolar macrophages from asthmatic patients. | 1998 | Eur. Respir. J. | pmid:9648962 |
| Matsumoto K et al. | Proinflammatory cytokine-induced and chemical mediator-induced IL-8 expression in human bronchial epithelial cells through p38 mitogen-activated protein kinase-dependent pathway. | 1998 | J. Allergy Clin. Immunol. | pmid:9648711 |
| Watson F and Edwards SW | Stimulation of primed neutrophils by soluble immune complexes: priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647777 |
| Qayumi AK et al. | The role of platelet-activating factor in regional myocardial ischemia-reperfusion injury. | 1998 | Ann. Thorac. Surg. | pmid:9647083 |
| Shouji K et al. | Platelet-activating factor is a key mediator of pulmonary vasoconstriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung. | 1998 | Shock | pmid:9645492 |
| Derewenda ZS and Derewenda U | The structure and function of platelet-activating factor acetylhydrolases. | 1998 | Cell. Mol. Life Sci. | pmid:9645224 |
| Jung KY et al. | Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. | 1998 | J. Nat. Prod. | pmid:9644071 |
| Botitsi E et al. | Metabolic fate of platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) in FRTL5 cells. | 1998 | J. Lipid Res. | pmid:9643362 |
| Mackness B et al. | Lack of protection against oxidative modification of LDL by avian HDL. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642147 |
| Izuoka T et al. | Role of platelet-activating factor on extravascular lung water after coronary reperfusion in dogs. | 1998 | Jpn. J. Physiol. | pmid:9639551 |
| Grassi S et al. | Role of platelet-activating factor in long-term potentiation of the rat medial vestibular nuclei. | 1998 | J. Neurophysiol. | pmid:9636125 |
| Beck-Speier I et al. | Pro-inflammatory response of alveolar macrophages induced by sulphite: studies with lucigenin-dependent chemiluminescence. | 1998 Mar-Apr | J. Biolumin. Chemilumin. | pmid:9633012 |