Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kulinski JM et al. | Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. | 2016 | Eur. J. Pharmacol. | pmid:25941085 |
| Nimjee SM et al. | Translation and Clinical Development of Antithrombotic Aptamers. | 2016 | Nucleic Acid Ther | pmid:26882082 |
| Moschos MM et al. | Impact of prostaglandin glaucoma drops on platelet-activating factor action: an in vitro study. | 2016 | Drug Des Devel Ther | pmid:27994439 |
| Vadas P | The platelet-activating factor pathway in food allergy and anaphylaxis. | 2016 | Ann. Allergy Asthma Immunol. | pmid:27788869 |
| Pike DP et al. | Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode. | 2016 | Lipids | pmid:27757707 |
| Täubel J et al. | Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. | 2016 | PLoS ONE | pmid:27632557 |
| Hoenderdos K et al. | Hypoxia upregulates neutrophil degranulation and potential for tissue injury. | 2016 | Thorax | pmid:27581620 |
| Watanabe M et al. | Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | 2016 | Am. J. Vet. Res. | pmid:27580108 |
| González-Núñez V et al. | Rupatadine: global safety evaluation in allergic rhinitis and urticaria. | 2016 | Expert Opin Drug Saf | pmid:27500993 |
| Wang M et al. | The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. | 2016 | Life Sci. | pmid:26808090 |
| Bihl JC et al. | UVB Generates Microvesicle Particle Release in Part Due to Platelet-activating Factor Signaling. | 2016 | Photochem. Photobiol. | pmid:26876152 |
| Reiner B et al. | Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling. | 2016 | Neurosci. Lett. | pmid:26808643 |
| Unsal E et al. | Effects of pentoxifylline and platelet activating factor on sperm DNA damage. | 2016 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:26748389 |
| Park JH et al. | Glucosamine suppresses platelet-activating factor-induced activation of microglia through inhibition of store-operated calcium influx. | 2016 | Environ. Toxicol. Pharmacol. | pmid:26745504 |
| RodrÃguez M et al. | Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells. | 2016 | Biochem. Pharmacol. | pmid:26673542 |
| Aquino EN et al. | Proteomic Analysis of Neutrophil Priming by PAF. | 2016 | Protein Pept. Lett. | pmid:26631175 |
| Kim HK et al. | Glutamine Prevents Late-Phase Anaphylaxis via MAPK Phosphatase 1-Dependent Cytosolic Phospholipase A2 Deactivation. | 2016 | Int. Arch. Allergy Immunol. | pmid:27838690 |
| Laidlaw TM and Boyce JA | Platelets in patients with aspirin-exacerbated respiratory disease. | 2015 | J. Allergy Clin. Immunol. | pmid:26051947 |
| Sahu RP | Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells. | 2015 | Mol Med Rep | pmid:25695262 |
| Reznichenko A and Korstanje R | The role of platelet-activating factor in mesangial pathophysiology. | 2015 | Am. J. Pathol. | pmid:25655028 |
| Jeewandara C et al. | Platelet activating factor contributes to vascular leak in acute dengue infection. | 2015 | PLoS Negl Trop Dis | pmid:25646838 |
| Valli A et al. | Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways. | 2015 | Oncotarget | pmid:25605240 |
| Yamaguchi M et al. | A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. | 2015 | Biochem. Pharmacol. | pmid:25577975 |
| Johnson M et al. | Levocetirizine and rupatadine in chronic idiopathic urticaria. | 2015 | Int. J. Dermatol. | pmid:25521304 |
| Kim H et al. | Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. | 2015 | J. Bone Miner. Metab. | pmid:25501698 |
| Mullol J et al. | Update on rupatadine in the management of allergic disorders. | 2015 | Allergy | pmid:25491409 |
| Zhao YM and Maimone TJ | Short, enantioselective total synthesis of chatancin. | 2015 | Angew. Chem. Int. Ed. Engl. | pmid:25470723 |
| Kattan JD and Sicherer SH | Optimizing the diagnosis of food allergy. | 2015 | Immunol Allergy Clin North Am | pmid:25459577 |
| Zelanis A et al. | Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. | 2015 | J Proteomics | pmid:25452133 |
| Larkin EK et al. | New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25408961 |
| Kooijman S et al. | Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. | 2015 | J. Thromb. Haemost. | pmid:25345495 |
| Jasamai M et al. | Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species. | 2015 | Nat. Prod. Res. | pmid:25332053 |
| Detopoulou P et al. | The relation of diet with PAF and its metabolic enzymes in healthy volunteers. | 2015 | Eur J Nutr | pmid:24639073 |
| Ohshima N et al. | New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity. | 2015 | J. Biol. Chem. | pmid:25528375 |
| Pałgan K and Bartuzi Z | Platelet activating factor in allergies. | 2015 | Int J Immunopathol Pharmacol | pmid:26486136 |
| Hergott CB et al. | Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. | 2015 | J. Clin. Invest. | pmid:26426079 |
| Speciani AF and Piuri G | Measuring Biomarkers for an Innovative Personal Food Profile. | 2015 | J Am Coll Nutr | pmid:26400432 |
| Pei HX et al. | Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats. | 2015 | Pharmacology | pmid:26382046 |
| Tiniakou I et al. | Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. | 2015 | Atherosclerosis | pmid:26363436 |
| Vlachogianni IC et al. | Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. | 2015 | Prostaglandins Other Lipid Mediat. | pmid:26358846 |
| Sato A et al. | Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. | 2015 | Peptides | pmid:26348270 |
| Damiani E et al. | Platelet-Activating Factor Induces Epigenetic Modifications in Human Mast Cells. | 2015 | J. Invest. Dermatol. | pmid:26316070 |
| Starossom SC et al. | Platelets Play Differential Role During the Initiation and Progression of Autoimmune Neuroinflammation. | 2015 | Circ. Res. | pmid:26294656 |
| Morita K et al. | [Pain relieving effect of platelet-activating factor (PAF) antagonists in a bone cancer pain model]. | 2015 | Nippon Yakurigaku Zasshi | pmid:26256746 |
| Plotkowski MC et al. | Contribution of the platelet activating factor signaling pathway to cerebral microcirculatory dysfunction during experimental sepsis by ExoU producing Pseudomonas aeruginosa. | 2015 | Pathog Dis | pmid:26187894 |
| Sato A et al. | Biotinylated heptapeptides substituted with a D-amino acid as platelet-activating factor inhibitors. | 2015 | Eur. J. Pharmacol. | pmid:26142829 |
| Sala-Cunill A and Cardona V | Biomarkers of anaphylaxis, beyond tryptase. | 2015 | Curr Opin Allergy Clin Immunol | pmid:26110683 |
| Gao L et al. | Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. | 2015 | J. Clin. Invest. | pmid:26098214 |
| Gill P et al. | Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis. | 2015 | J. Allergy Clin. Immunol. | pmid:26051949 |
| de Oliveira MC et al. | Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. | 2015 | J. Nutr. Biochem. | pmid:26013469 |