Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemorrhage D006470 15 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypotension D007022 41 associated lipids
Ileal Diseases D007077 3 associated lipids
Ileitis D007079 2 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Infertility, Male D007248 11 associated lipids
Inflammation D007249 119 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Klebsiella Infections D007710 7 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukopenia D007970 9 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lupus Nephritis D008181 8 associated lipids
Lymphoma D008223 18 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Memory Disorders D008569 33 associated lipids
Meningioma D008579 11 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Migraine Disorders D008881 11 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Multiple Trauma D009104 2 associated lipids
Nasal Polyps D009298 26 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
pmid:
pmid:3360596
Kelesidis T et al. The Role of Platelet-Activating Factor in Chronic Inflammation, Immune Activation, and Comorbidities Associated with HIV Infection. AIDS Rev pmid:26616844
pmid:9870780
Colwell JA et al. Platelet adhesion and aggregation in diabetes mellitus. 1979 Metab. Clin. Exp. pmid:122293
Benveniste J et al. [Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine]. 1979 C. R. Acad. Sci., D, Sci. Nat. pmid:121258
Namm DH and High JA Thrombin-induced formation of a polar lipid material within platelets that possesses platelet-activating activity. 1980 Thromb. Res. pmid:7209881
Tencé V et al. Release, purification, and characterization of platelet-activating factor (PAF). 1980 Biochimie pmid:17941181
Bussolino F and Benveniste J Pharmacological modulation of platelet-activating factor (PAF) release from rabbit leucocytes. I. Role of cAMP. 1980 Immunology pmid:6159308
Bussolino F and Camussi G Effect of prostacyclin on platelet-activating factor induced rabbit and platelet aggregation. 1980 Prostaglandins pmid:6258196
Vargaftig BB et al. Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). 1980 Agents Actions pmid:7270336
Godfroid JJ et al. Platelet activating factor (PAF-acether): total synthesis of 1-O-octadecyl 2-O-acetyl sn-glycero-3-phosphoryl choline. 1980 FEBS Lett. pmid:7409144
Clark PO et al. Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils. 1980 Biochim. Biophys. Acta pmid:7357030
[Do you know PAF?]. 1980 Nouv Presse Med pmid:7367260
Farr RS et al. Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF). 1980 Clin. Immunol. Immunopathol. pmid:7371225
McManus LM et al. Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit. 1980 J. Immunol. pmid:7373056
Cusack NJ Platelet-activating factor. 1980 Nature pmid:7374771
Hanahan DJ et al. Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine. 1980 J. Biol. Chem. pmid:7380824
Pirotzky E et al. [Release of platelet activating factor (P.A.F.-acether) by isolated perfused rat kidney]. 1980 C. R. Acad. Sci., D, Sci. Nat. pmid:6772322
Chignard M et al. Platelet-activating factor (PAF-acether) secretion from platelets: effect of aggregating agents. 1980 Br. J. Haematol. pmid:6778498
Vargaftig BB et al. One, two, three or more pathways for platelet aggregation. 1980 Acta Med. Scand. Suppl. pmid:6779505
Arnoux B et al. Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. 1980 Eur. J. Clin. Invest. pmid:6788561
Halonen M et al. Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit. 1980 Am. Rev. Respir. Dis. pmid:7458063
Kirchmaier CM et al. A platelet stimulating fraction in human and animal tissues. 1980 Artery pmid:6971084
Shaw JO and Henson PM The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. 1980 Am. J. Pathol. pmid:6987890
Vargaftig BB et al. Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives. 1980 Eur. J. Pharmacol. pmid:6995139
Pinckard RN et al. Molecular pathobiology of acetyl glyceryl ether phosphorylcholine: evidence for the structural and functional identity with platelet-activating factor. 1980 J Reticuloendothel Soc pmid:7003140
Polonsky J et al. Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids. 1980 Proc. Natl. Acad. Sci. U.S.A. pmid:6938950
Check WA A new age in asthma research: study of chemical mediators. 1980 Aug 22-29 JAMA pmid:6104737
Suzuki K et al. The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor. 1980 Feb 1-15 Thromb. Res. pmid:6966083
Chignard M et al. [Platelet aggregation and platelet activating factor (author's transl)]. 1980 Oct-Dec J Pharmacol pmid:7206730
Camussi G et al. Platelet-activating factor (PAF), a mediator of platelet aggregation. Effect of corticosteroids on PAF-induced platelet aggregation. 1980 Oct-Dec Minerva Nefrol pmid:7254682
Shaw JO et al. Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). 1981 Biochim. Biophys. Acta pmid:7213765
Shaw JO et al. Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor). 1981 J. Immunol. pmid:6267133
Slauson DO and Sanchez-Vizcaino JM Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. 1981 Vet. Pathol. pmid:6170156
O'Donnell MC and Fiedel BA Histamine secretion from human leucocytes stimulated by basophil-derived platelet-activating factor. 1981 Scand. J. Immunol. pmid:6171870
Benveniste J Platelet-activating factor (PAF-acether): present status. 1981 Agents Actions pmid:6176101
Satouchi K et al. Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation. 1981 J. Biol. Chem. pmid:7217088
O'Flaherty JT et al. 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. 1981 Am. J. Pathol. pmid:7223864
Blank ML et al. In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid. 1981 Life Sci. pmid:7300575
Satouchi K et al. Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets. 1981 Arch. Biochem. Biophys. pmid:7305392
Gil MG et al. Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes. 1981 Biochem. Biophys. Res. Commun. pmid:7306113
Pinckard RN et al. Acetyl glyceryl ether phosphorylcholine: platelet-activating factor. 1981 Int. Arch. Allergy Appl. Immunol. pmid:7309256
Czarnetzki BM and Muramatsu T Saturated and unsaturated 1-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines derived from ratfish liver oil: effect on human leukocyte migration. 1981 Chem. Phys. Lipids pmid:7318048
Czarnetzki BM and Benveniste J Effect of 1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) on leukocytes I. Analysis of the in vitro migration of human neutrophils. 1981 Chem. Phys. Lipids pmid:7318049
Lee TC et al. 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets. 1981 Biochem. Biophys. Res. Commun. pmid:6797422
Colwell JA Studies on the pathogenesis of diabetic vascular disease. 1981 J S C Med Assoc pmid:7022022
Wintroub BU and Soter NA Biology of the mast cell and its role in cutaneous inflammation. 1981 Springer Semin. Immunopathol. pmid:7022722
Vargaftig BB et al. Background and present status of research on platelet-activating factor (PAF-acether). 1981 Ann. N. Y. Acad. Sci. pmid:7023317
Heymans F et al. New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures. 1981 Biochim. Biophys. Acta pmid:7306563