Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| TatarskiÄ AR et al. | [Use of plateletpheresis in the treatment of bronchial asthma]. | 1991 | Ter. Arkh. | pmid:2063345 |
| TatarskiÄ AR and Emirova AS | [The role of the thrombocytes in the pathogenesis of certain forms of bronchial asthma]. | 1990 | Ter. Arkh. | pmid:2142338 |
| Willerson JT | Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products. | 1995 | Tex Heart Inst J | pmid:7787465 |
| Desquand S | [Effects of PAF antagonists in experimental models. Therapeutical perspectives]. | 1993 Nov-Dec | Therapie | pmid:8091344 |
| Zardini DM and Tschirhart EJ | [Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion]. | 1999 Jan-Feb | Therapie | pmid:10216433 |
| Roudebush WE and Diehl JR | Platelet-activating factor content in boar spermatozoa correlates with fertility. | 2001 | Theriogenology | pmid:11396471 |
| O' Meara CM et al. | Relationship between in vitro sperm functional tests and in vivo fertility of rams following cervical artificial insemination of ewes with frozen-thawed semen. | 2008 | Theriogenology | pmid:18248736 |
| Bathgate R et al. | Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. | 2007 | Theriogenology | pmid:17157372 |
| Kumar S and Sharma A | Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. | 2005 | Theriogenology | pmid:15763101 |
| Shindo K et al. | Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor. | 1997 | Thorax | pmid:9516893 |
| Chung KF | Platelet activating factor revisited. | 1997 | Thorax | pmid:9516891 |
| Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
| McFadden RG et al. | Effect of platelet activating factor (PAF) on the migration of human lymphocytes. | 1995 | Thorax | pmid:7660340 |
| Spring J et al. | Failure of salmeterol to inhibit circulating white cell responses and bronchoconstriction induced by platelet activating factor. | 1992 | Thorax | pmid:1361250 |
| Chung KF et al. | Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man. | 1989 | Thorax | pmid:2648645 |
| Chung KF and Barnes PJ | Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects. | 1989 | Thorax | pmid:2648646 |
| Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
| Spencer DA et al. | Participation of the cysteinyl leukotrienes in the acute bronchoconstrictor response to inhaled platelet activating factor in man. | 1991 | Thorax | pmid:1858084 |
| Freitag A et al. | Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. | 1993 | Thorax | pmid:8346486 |
| Hoenderdos K et al. | Hypoxia upregulates neutrophil degranulation and potential for tissue injury. | 2016 | Thorax | pmid:27581620 |
| Alabaster VA and Moore BA | New perspectives on basic mechanisms in lung disease. 3. Drug intervention in asthma: present and future. | 1993 | Thorax | pmid:8493636 |
| Moon DG et al. | Platelet modulation of neutrophil superoxide anion production. | 1990 | Thromb. Haemost. | pmid:2160133 |
| Steen VM et al. | The platelet-stimulating effect of adrenaline through alpha 2-adrenergic receptors requires simultaneous activation by a true stimulatory platelet agonist. Evidence that adrenaline per se does not induce human platelet activation in vitro. | 1993 | Thromb. Haemost. | pmid:8259557 |
| Nystrom ML et al. | Platelet shape change in whole blood: differential effects of endotoxin. | 1994 | Thromb. Haemost. | pmid:8091394 |
| Kavakli K et al. | Plasma platelet-activating factor (PAF) levels and desmopressin response in children with hemophilia A and von Willebrand's disease. | 1999 | Thromb. Haemost. | pmid:10235463 |
| Page CP et al. | An in vivo model for studying platelet aggregation and disaggregation. | 1982 | Thromb. Haemost. | pmid:7051409 |
| Frelinger AL et al. | Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. | 2011 | Thromb. Haemost. | pmid:21713327 |
| Tranquille N and Emeis JJ | The role of cyclic nucleotides in the release of tissue-type plasminogen activator and von Willebrand factor. | 1993 | Thromb. Haemost. | pmid:8097063 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE3 on human platelet function. | 2012 | Thromb. Haemost. | pmid:22318645 |
| Rainger GE et al. | Neutrophils rolling on immobilised platelets migrate into homotypic aggregates after activation. | 1998 | Thromb. Haemost. | pmid:9657445 |
| Wal F et al. | PAF-acether may not mediate the third pathway of platelet aggregation since self-desensitization reduces the effects of low thrombin but enhances those of convulxin. | 1985 | Thromb. Haemost. | pmid:3992525 |
| Selak MA | Neutrophil elastase potentiates cathepsin G-induced platelet activation. | 1992 | Thromb. Haemost. | pmid:1333649 |
| Smith SV and Brinkhous KM | Inventory of exogenous platelet-aggregating agent derived from venoms. | 1991 | Thromb. Haemost. | pmid:1771620 |
| Xavier RG et al. | Enhanced platelet aggregation and activation under conditions of hypothermia. | 2007 | Thromb. Haemost. | pmid:18064324 |
| van Giezen JJ et al. | Fibrinolytic activity in blood is distributed over a cellular and the plasma fraction which can be modulated separately. | 1994 | Thromb. Haemost. | pmid:7740459 |
| Hermán F et al. | Decreased sensitivity of platelets to platelet-activating factor in migraine patients during the headache-free interval. | 1989 | Thromb. Haemost. | pmid:2814933 |
| Mohanty D and Hilgard P | A new platelet aggregating material (PAM) in an experimentally induced rat fibrosarcoma. | 1984 | Thromb. Haemost. | pmid:6740552 |
| Iacoviello L et al. | Enhanced vascular plasminogen activator (t-PA) release by epinephrine in aged rats. | 1995 | Thromb. Haemost. | pmid:7482413 |
| Sirolli V et al. | Platelet activation and platelet-erythrocyte aggregates in end-stage renal disease patients on hemodialysis. | 2001 | Thromb. Haemost. | pmid:11583316 |
| Wong T et al. | Platelet size affects both micro- and macro-aggregation: contributions of platelet number, volume fraction and cell surface. | 1989 | Thromb. Haemost. | pmid:2683192 |
| Hornby EJ and Perry CR | 1-O-hexadecyl-2-acetyl-sn-3-glycerophosphorylcholine (PAF): some effects on the aggregation of human platelets by thrombin or collagen. | 1983 | Thromb. Haemost. | pmid:6636035 |
| Montrucchio G et al. | Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. | 2003 | Thromb. Haemost. | pmid:14597983 |
| Handley DA et al. | Evidence for a direct effect on vascular permeability of platelet-activating factor induced hemoconcentration in the guinea pig. | 1985 | Thromb. Haemost. | pmid:4089809 |
| Prescott SM et al. | The role of platelet-activating factor in endothelial cells. | 1990 | Thromb. Haemost. | pmid:2274933 |
| Cargill DI et al. | Aggregation, release and desensitization induced in platelets from five species by platelet activating factor (PAF). | 1983 | Thromb. Haemost. | pmid:6879508 |
| Hermán F et al. | In vivo antiaggregatory action of platelet-activating factor in beagle dogs: role for prostacyclin. | 1991 | Thromb. Haemost. | pmid:2048053 |
| Chou KJ et al. | Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access. | 2004 | Thromb. Haemost. | pmid:15351860 |
| Ward JR et al. | Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. | 2005 | Thromb. Haemost. | pmid:16270639 |
| Satoh K et al. | Production of platelet-activating factor by porcine brain microvascular endothelial cells in culture. | 1995 | Thromb. Haemost. | pmid:8607119 |
| Handley DA et al. | Inhibition of PAF-induced systemic responses in the rat, guinea pig, dog and primate by the receptor antagonist SRI 63-441. | 1986 | Thromb. Haemost. | pmid:3775689 |