Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemorrhage D006470 15 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Hepatitis, Alcoholic D006519 5 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Hypercholesterolemia D006937 91 associated lipids
Hyperlipoproteinemia Type II D006938 22 associated lipids
Hyperinsulinism D006946 27 associated lipids
Hypersensitivity D006967 22 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Hypertension D006973 115 associated lipids
Hypertension, Portal D006975 12 associated lipids
Hypertension, Pulmonary D006976 32 associated lipids
Hypotension D007022 41 associated lipids
Ileal Diseases D007077 3 associated lipids
Ileitis D007079 2 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Infertility, Male D007248 11 associated lipids
Inflammation D007249 119 associated lipids
Intestinal Obstruction D007415 6 associated lipids
Ischemia D007511 18 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Klebsiella Infections D007710 7 associated lipids
Leukemia D007938 74 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Leukopenia D007970 9 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Liver Cirrhosis, Experimental D008106 36 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lupus Nephritis D008181 8 associated lipids
Lymphoma D008223 18 associated lipids
Malabsorption Syndromes D008286 16 associated lipids
Mammary Neoplasms, Experimental D008325 67 associated lipids
Medulloblastoma D008527 22 associated lipids
Melanoma D008545 69 associated lipids
Memory Disorders D008569 33 associated lipids
Meningioma D008579 11 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Migraine Disorders D008881 11 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Multiple Trauma D009104 2 associated lipids
Nasal Polyps D009298 26 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Li SH et al. Effects of platelet-activating factor antagonist SRI 63-441 on endotoxin-induced changes in rat mesenteric microcirculation. 1991 Yao Xue Xue Bao pmid:1887797
Fang J and Zheng QY [Inhibitory effect of esculentoside A on platelet activating factor released from calcimycin induced rat peritoneal macrophages]. 1991 Yao Xue Xue Bao pmid:1823713
Ju DW et al. [Leflunomide inhibits PAF induced DNA synthesis in rabbit synovial cells and PAF production from rat peritoneal macrophages]. 1994 Yao Xue Xue Bao pmid:8042517
Hu JH et al. [Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs]. 1994 Yao Xue Xue Bao pmid:7976350
Ma Y et al. [PAF antagonistic benzofuran neolignans from Piper kadsura]. 1993 Yao Xue Xue Bao pmid:8237383
Ju DW et al. Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages. 1993 Yao Xue Xue Bao pmid:8009983
Nie ZG and Wang WJ [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. 2003 Yao Xue Xue Bao pmid:12778742
Zhang LL et al. [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. 2007 Yao Xue Xue Bao pmid:17520822
Peng SY et al. Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. 2006 Yao Xue Xue Bao pmid:16671547
Mao YJ et al. [Effect of ginkgolide B on the function of rat aorta smooth cells and U937 cells stimulated by oxLDL]. 2006 Yao Xue Xue Bao pmid:16683525