Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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pmid: | ||||
pmid:3360596 | ||||
pmid:9870780 | ||||
Pastores SM et al. | Posttraumatic multiple-organ dysfunction syndrome: role of mediators in systemic inflammation and subsequent organ failure. | 1996 | Acad Emerg Med | pmid:8727633 |
Goldring WP and Pattenden G | The phomactins. A novel group of terpenoid platelet activating factor antagonists related biogenetically to the taxanes. | 2006 | Acc. Chem. Res. | pmid:16700534 |
Yamada T et al. | Effects of inhaled nitric oxide on platelet-activating factor-induced pulmonary hypertension in dogs. | 1998 | Acta Anaesthesiol Scand | pmid:9542566 |
Nathan N et al. | Variations in blood platelet-activating-factor levels after protamine reversal of heparin in humans. | 1992 | Acta Anaesthesiol Scand | pmid:1574976 |
Sipka S et al. | Atropine is an inhibitor of the chemiluminescence induced by platelet-activating factor in human neutrophils. | 1987 | Acta Biochim. Biophys. Hung. | pmid:3132002 |
Ren J et al. | Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits. | 2018 | Acta Cir Bras | pmid:29412230 |
Peterson JR et al. | Platelet activating factor antagonist design. 3. X-ray crystal structure and intermolecular crystal lattice interactions of methyl trans-4-acetoxymethyl-4,5-dihydro-2,5-bis(3,4-methylenedioxyphenyl)- 3-furancarboxylate. | 1989 | Acta Crystallogr C | pmid:2604943 |
Peterson JR et al. | Platelet activating factor antagonist design: structure of methyl trans-5-(3,4-dimethoxyphenyl)-2,3,4,5-tetrahydro-2-oxo-4- furancarboxylate. | 1989 | Acta Crystallogr C | pmid:2610971 |
Peterson JR et al. | Platelet activating factor antagonist design. 2. X-ray structure of dimethyl 2,3,4,5-tetrahydro-5 beta-(3,4-methylenedioxyphenyl)-2-oxo-3 beta-(3,4,5-trimethoxybenzoyl)-3 alpha,4 alpha-furandicarboxylate. | 1989 | Acta Crystallogr C | pmid:2610989 |
Stensland JB et al. | Platelet activating factor antagonists. Structure of N,N'-bis(3,4,5-trimethoxybenzoyl)-2-piperazinylmethyl 2,2-dimethylpropanoate. | 1991 | Acta Crystallogr C | pmid:1930821 |
Juhlin L and Pihl-Lundin I | Effects of antihistamines on cutaneous reactions and influx of eosinophils after local injection of PAF, kallikrein, compound 48/80 and histamine in patients with chronic urticaria and healthy subjects. | 1992 | Acta Derm. Venereol. | pmid:1357858 |
Juhlin L and Rihoux JP | Effect of cetirizine on cutaneous reactions to PAF, kallikrein and serum in patients with chronic urticaria. | 1990 | Acta Derm. Venereol. | pmid:1969202 |
Fjellner B and Hägermark O | Experimental pruritus evoked by platelet activating factor (PAF-acether) in human skin. | 1985 | Acta Derm. Venereol. | pmid:2416164 |
Abramovici Y et al. | Control of the proliferation and differentiation of GEJ under platelet aggregating factor treatment. | 1987 | Acta Endocrinol Suppl (Copenh) | pmid:3475908 |
Plachot M | Markers for establishing the adequacy of embryonal development in assisted conception. | 1993 Sep-Oct | Acta Eur. Fertil. | pmid:7985464 |
Aderka D et al. | Morphological platelet anomalies in thrombotic thrombocytopenic purpura. | 1982 | Acta Haematol. | pmid:6801893 |
Bussolino F et al. | Platelet-activating factor--a powerful lipid autacoid possibly involved in microangiopathy. | 1986 | Acta Haematol. | pmid:3019063 |
Akisü M et al. | The effect of L-carnitine on platelet activating factor concentration in the immature rat model of hypoxic-ischemic brain injury. | 1998 | Acta Med. Okayama | pmid:9781268 |
Hashimoto K et al. | Comparison of the effects of intra-third ventricular administration of interleukin-1 or platelet activating factor on ACTH secretion and the sympathetic-adrenomedullary system in conscious rats. | 1993 | Acta Med. Okayama | pmid:8384777 |
Vargaftig BB et al. | One, two, three or more pathways for platelet aggregation. | 1980 | Acta Med. Scand. Suppl. | pmid:6779505 |
Hirasima Y et al. | Platelet-activating factor (PAF) and the development of chronic subdural haematoma. | 1994 | Acta Neurochir (Wien) | pmid:7998491 |
Hirashima Y et al. | Platelet-activating factor (PAF) and the formation of chronic subdural haematoma. Measurement of plasma PAF levels and anti-PAF immunoglobulin titers. | 1995 | Acta Neurochir (Wien) | pmid:8748861 |
Hirashima Y et al. | Platelet-activating factor and antiphospholipid antibodies in subarachnoid haemorrhage. | 1994 | Acta Neurochir (Wien) | pmid:7847132 |
Hallenbeck JM | Blood-damaged tissue interaction in experimental brain ischemia. | 1994 | Acta Neurochir Suppl (Wien) | pmid:7976554 |
Tokutomi T et al. | Effect of platelet-activating factor antagonist on brain injury in rats. | 1994 | Acta Neurochir Suppl (Wien) | pmid:7976632 |
Maeda T et al. | Hemodynamic depression and microthrombosis in the peripheral areas of cortical contusion in the rat: role of platelet activating factor. | 1997 | Acta Neurochir. Suppl. | pmid:9416292 |
Khan SN et al. | Response to platelet-activating factor of platelets from patients with multiple sclerosis. | 1985 | Acta Neurol. Scand. | pmid:3993327 |
Satoh K et al. | Increased levels of blood platelet-activating factor (PAF) and PAF-like lipids in patients with ischemic stroke. | 1992 | Acta Neurol. Scand. | pmid:1574985 |
Doly M et al. | Protective effect of a specific PAF antagonist on vincristine-induced experimental retinopathy. | 1995 | Acta Ophthalmol Scand | pmid:7656145 |
Pettorossi VE and Grassi S | Different contributions of platelet-activating factor and nitric oxide in long-term potentiation of the rat medial vestibular nuclei. | 2001 | Acta Otolaryngol Suppl | pmid:11677732 |
Nakano T et al. | Roxythromycin reinforces epithelial defence function in rabbit trachea. | 1998 | Acta Otolaryngol Suppl | pmid:9879427 |
Minami T et al. | Regional blood flow volume in the eustachian tube. | 1993 | Acta Otolaryngol Suppl | pmid:8452027 |
Lin J et al. | Effects of platelet-activating factor (PAF) receptor blockage on mucous glycoprotein secretion in cultured chinchilla middle ear epithelium. | 1996 | Acta Otolaryngol. | pmid:8820353 |
Terada N et al. | The effect of anti-VLA-4 monoclonal antibody on eosinophil accumulation and leukotriene production in nasal mucosa. | 1996 | Acta Otolaryngol. | pmid:8973726 |
Ganbo T and Hisamatsu K | Mucosal dysfunction and damage induced by platelet activating factor (PAF). | 1990 Nov-Dec | Acta Otolaryngol. | pmid:2284918 |
Minami T et al. | Effects of various inflammatory mediators on eustachian tube patency. | 1992 | Acta Otolaryngol. | pmid:1442015 |
Dolata J et al. | The influence of leukotrienes and platelet activating factor on mucociliary activity in the rabbit maxillary sinus. | 1990 Jan-Feb | Acta Otolaryngol. | pmid:2309553 |
Furukawa M et al. | Presence of platelet-activating factor in nasal polyps and eosinophils. | 2002 | Acta Otolaryngol. | pmid:12542208 |
Lin J et al. | Dexamethasone inhibits mucous glycoprotein secretion via a phospholipase A2-dependent mechanism in cultured chinchilla middle ear epithelial cells. | 1997 | Acta Otolaryngol. | pmid:9199527 |
Bellioni P et al. | [Histomorphological changes in nasal polyps in patients with glucose metabolism disorders]. | 1988 Nov-Dec | Acta Otorhinolaryngol Ital | pmid:3247845 |
Akisü M et al. | Plasma platelet-activating factor levels in newborn infants with and without perinatal asphyxia: is it an additional marker of perinatal asphyxia? | 1998 | Acta Paediatr Jpn | pmid:9821700 |
Hüseyinov A et al. | Plasma and urinary platelet activating factor concentrations and leukotriene releasing activity of leukocytes in steroid sensitive nephrotic syndrome of childhood. | 1998 | Acta Paediatr Jpn | pmid:9583202 |
Nagakura T et al. | Chemical mediators in hypersensitivity reactions. | 1990 | Acta Paediatr Jpn | pmid:1974103 |
Ewer AK | Role of platelet-activating factor in the pathophysiology of necrotizing enterocolitis. | 2002 | Acta Paediatr Suppl | pmid:12200892 |
Hsueh W et al. | Platelet-activating factor, tumor necrosis factor, hypoxia and necrotizing enterocolitis. | 1994 | Acta Paediatr Suppl | pmid:8086673 |
Dahlbäck M et al. | Bronchial anaphylaxis in actively sensitized Sprague Dawley rats: studies on mediators involved. | 1984 | Acta Pharmacol Toxicol (Copenh) | pmid:6431753 |
Saeed SA and Rasheed H | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | 2003 | Acta Pharmacol. Sin. | pmid:12511226 |
Penna C et al. | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. | 2009 | Acta Physiol (Oxf) | pmid:19432589 |
Lang F et al. | Osmotic shock-induced suicidal death of erythrocytes. | 2006 May-Jun | Acta Physiol (Oxf) | pmid:16734755 |
Kecskemeti V | Electrophysiological effects of platelet-activating factor (PAF) in guinea-pig cardiac preparations. | 1990 | Acta Physiol Hung | pmid:2371852 |
Balogh I et al. | Cytochemical effects of biologically active substances on the heart muscle. | 1990 | Acta Physiol Hung | pmid:2371866 |
Alving K et al. | The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. | 1991 | Acta Physiol. Scand. | pmid:1957709 |
Arner M and Högestätt ED | Endothelium-dependent relaxation and effects of prostacyclin, endothelin and platelet-activating factor in human hand veins and arteries. | 1991 | Acta Physiol. Scand. | pmid:1715111 |
Björk J et al. | Paf-acether (platelet-activating factor) increases microvascular permeability and affects endothelium-granulocyte interaction in microvascular beds. | 1983 | Acta Physiol. Scand. | pmid:6659994 |
Karlström G et al. | Renal and circulatory effects of medullipin I, as studied in the in-vivo cross-circulated isolated kidney and intact Wistar-Kyoto (WKY) rat. | 1989 | Acta Physiol. Scand. | pmid:2603751 |
Iversen VV et al. | Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. | 2005 | Acta Physiol. Scand. | pmid:16128692 |
Greiff L et al. | Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. | 1997 | Acta Physiol. Scand. | pmid:9338520 |
Zia-ul-Haq M et al. | Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876614 |
Rubio de Krömer MT et al. | Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. | 1995 | Acta Trop. | pmid:8546035 |
Konstantinov SM et al. | Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. | 1997 | Acta Trop. | pmid:9107362 |
Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
Bazan NG and Allan G | Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. | 1996 | Adv Neurol | pmid:8790822 |
Söling HD et al. | Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. | 1985 | Adv. Enzyme Regul. | pmid:4072796 |
Armant DR | Intracellular Ca2+ signaling and preimplantation development. | 2015 | Adv. Exp. Med. Biol. | pmid:25956298 |
Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
Proceedings of an International Symposium on Mechanisms of Platelet Activation and Control. London, United Kingdom, April 13-14, 1992. | 1993 | Adv. Exp. Med. Biol. | pmid:7911646 | |
Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
van den Bosch H et al. | The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. | 1996 | Adv. Exp. Med. Biol. | pmid:9131123 |
Dohi T et al. | Platelet-activating factor synthesis and its role in salivary glands. | 1996 | Adv. Exp. Med. Biol. | pmid:9131124 |
Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
Nakayama R et al. | Physiological action of PAF in yeast Saccharomyces cerevisiae. | 1996 | Adv. Exp. Med. Biol. | pmid:9131125 |
Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
Demopoulos CA and Antonopoulou S | A discovery trip to compounds with PAF-like activity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131127 |
Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |
Rementzis J et al. | Biologically active lipids from S. scombrus. | 1996 | Adv. Exp. Med. Biol. | pmid:9131128 |
Orevi M et al. | Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131129 |
Shimizu T et al. | Platelet-activating factor receptor. Gene structure and tissue-specific regulation. | 1996 | Adv. Exp. Med. Biol. | pmid:9131130 |
Sato S et al. | Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131133 |
Dohi T et al. | Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131134 |
Lee T | Acetylation of sphingosine by PAF-dependent transacetylase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131136 |
Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
McKay C et al. | The use of lexipafant in the treatment of acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131175 |
Tamura G et al. | Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. | 1996 | Adv. Exp. Med. Biol. | pmid:9131176 |
Albert DH et al. | Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. | 1996 | Adv. Exp. Med. Biol. | pmid:9131177 |
Bussolino F et al. | Role of platelet activating factor in the adhesion process of polymorphonuclear neutrophils to endothelial cells. | 1991 | Adv. Exp. Med. Biol. | pmid:1767755 |
Rabinovici R et al. | PAF and TNF alpha interactions in the pathophysiology of septic shock. | 1991 | Adv. Exp. Med. Biol. | pmid:1818486 |
Droy-Lefaix MT et al. | Effect of the platelet-activating factor (PAF) antagonist, BN 52021, on free radical-induced intestinal ischemia-reperfusion damage in the rat. | 1990 | Adv. Exp. Med. Biol. | pmid:2244522 |
Kochanek PM et al. | Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. | 1990 | Adv. Exp. Med. Biol. | pmid:2096640 |
Camussi G et al. | Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. | 1990 | Adv. Exp. Med. Biol. | pmid:2096695 |
Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
Winkler JD et al. | Inhibitors of arachidonate metabolism and effects on PAF production. | 1996 | Adv. Exp. Med. Biol. | pmid:9131119 |
Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
Bazan NG | Bioactive lipids and gene expression in neuronal plasticity. | 1998 | Adv. Exp. Med. Biol. | pmid:10079836 |
Jin N et al. | Platelet activating factor causes relaxation of isolated pulmonary artery and aorta. | 1991 | Adv. Exp. Med. Biol. | pmid:1803920 |
Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |