Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Ear Diseases D004427 7 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Agranulocytosis D000380 7 associated lipids
Shock D012769 11 associated lipids
Polycythemia Vera D011087 13 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Shock, Septic D012772 11 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Conjunctivitis D003231 7 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Death, Sudden D003645 12 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Neutropenia D009503 15 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Meningioma D008579 11 associated lipids
Multiple Trauma D009104 2 associated lipids
Cluster Headache D003027 4 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Behcet Syndrome D001528 7 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Migraine Disorders D008881 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Watschinger K and Werner ER Orphan enzymes in ether lipid metabolism. 2013 Biochimie pmid:22771767
Yamazaki Y et al. A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. 2013 Biochem. Pharmacol. pmid:23817078
Xia SH et al. Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. 2013 World J. Gastroenterol. pmid:23840141
Mazereeuw G et al. Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. 2013 Neurosci Biobehav Rev pmid:23800745
Wang C et al. Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. 2013 Lipids Health Dis pmid:23805935
Nettis E et al. Rupatadine for the treatment of urticaria. 2013 Expert Opin Pharmacother pmid:23806068
Sato A and Ebina K [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. 2013 Seikagaku pmid:23819394
Compalati E and Canonica GW Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. 2013 Curr Med Res Opin pmid:23826741
Xu H et al. Targeted lipidomics - advances in profiling lysophosphocholine and platelet-activating factor second messengers. 2013 FEBS J. pmid:23826908
Liu G et al. Characterization of streptococcal platelet-activating factor acetylhydrolase variants that are involved in innate immune evasion. 2013 Infect. Immun. pmid:23774595
Sirangelo I et al. Amyloid toxicity and platelet-activating factor signaling. 2013 J. Cell. Physiol. pmid:23169529
Murakami M and Lambeau G Emerging roles of secreted phospholipase A(2) enzymes: an update. 2013 Biochimie pmid:23022039
Vadas P et al. Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. 2013 J. Allergy Clin. Immunol. pmid:23040367
Kawano DF and Carvalho I Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease. 2013 Mini Rev Med Chem pmid:23544467
Wei JF et al. Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. 2013 Biomed Res Int pmid:23509689
Frost BL and Caplan MS Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. 2013 Semin. Pediatr. Surg. pmid:23611612
Renteria LS et al. RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. 2013 Cell Prolif. pmid:24033386
Verouti SN et al. Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. 2013 Int J Artif Organs pmid:23335378
Zhao C et al. Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. 2013 PLoS ONE pmid:24367540
Barbier M et al. Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. 2013 MBio pmid:23653444