Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yang HQ et al. | PMS777, a new cholinesterase inhibitor with anti-platelet activated factor activity, regulates amyloid precursor protein processing in vitro. | 2009 | Neurochem. Res. | pmid:18758955 |
| Shindou H and Shimizu T | [New development of lysophospholipid acyltransferases]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19205351 |
| Seki M et al. | Expression and DNA microarray analysis of a platelet activating factor-related molecule in severe pneumonia in mice due to influenza virus and bacterial co-infection. | 2009 | Jpn. J. Infect. Dis. | pmid:19168951 |
| Schneider DJ and Sobel BE | Streamlining the design of promising clinical trials: in-vitro testing of antithrombotic regimens and multiple agonists of platelet activation. | 2009 | Coron. Artery Dis. | pmid:19194284 |
| Li J et al. | Protection of PMS777, a new AChE inhibitor with PAF antagonism, against amyloid-beta-induced neuronal apoptosis and neuroinflammation. | 2009 | Cell. Mol. Neurobiol. | pmid:19194797 |
| Fité-Mora R | Torsade de pointes associated with rupatadine. | 2009 | Rev Esp Cardiol | pmid:19268083 |
| Kim DD et al. | Independent regulation of periarteriolar and perivenular nitric oxide mechanisms in the in vivo hamster cheek pouch microvasculature. | 2009 | Microcirculation | pmid:19235626 |
| Musio S et al. | Anaphylaxis to a self-peptide in the absence of mast cells or histamine. | 2009 | Lab. Invest. | pmid:19188909 |
| Shi B et al. | [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19695175 |
| Rastogi P and McHowat J | Inhibition of calcium-independent phospholipase A2 prevents inflammatory mediator production in pulmonary microvascular endothelium. | 2009 | Respir Physiol Neurobiol | pmid:19059366 |
| Wen J et al. | Simultaneous determination of rupatadine and its metabolite desloratadine in human plasma by a sensitive LC-MS/MS method: application to the pharmacokinetic study in healthy Chinese volunteers. | 2009 | J Pharm Biomed Anal | pmid:19059745 |
| Rehse K et al. | New 1H-pyrazole-4-carboxamides with antiplatelet activity. | 2009 | Arch. Pharm. (Weinheim) | pmid:19051198 |
| Detopoulou P et al. | Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure. | 2009 | Clin. Biochem. | pmid:18955040 |
| Eggert D et al. | Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. | 2009 | J. Neuroimmunol. | pmid:19541372 |
| Coy ED et al. | Macrophyllin-type bicyclo[3.2.1]octanoid neolignans from the leaves of Pleurothyrium cinereum. | 2009 | J. Nat. Prod. | pmid:19548690 |
| Coy-Barrera ED et al. | PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). | 2009 | Phytochemistry | pmid:19674762 |
| Kordan W et al. | Effect of platelet-activating factor on motility, plasmalemma integrity, the process of capacitation and acrosome reaction of fresh and cryopreserved boar spermatozoa. | 2009 | Pol J Vet Sci | pmid:19645346 |
| Poisson C et al. | Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. | 2009 | J. Immunol. | pmid:19620302 |
| Jeong YI et al. | The novel role of platelet-activating factor in protecting mice against lipopolysaccharide-induced endotoxic shock. | 2009 | PLoS ONE | pmid:19652714 |
| Keck M et al. | Pathophysiology of burns. | 2009 | Wien Med Wochenschr | pmid:19652939 |
| Tung JP et al. | Respiratory burst function of ovine neutrophils. | 2009 | BMC Immunol. | pmid:19422720 |
| Penna C et al. | Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. | 2009 | Acta Physiol (Oxf) | pmid:19432589 |
| He YG et al. | Functional analysis of platelet-activating factor in the retinal pigment epithelial cells and choroidal endothelial cells. | 2009 | Curr. Eye Res. | pmid:19958112 |
| Babayigit A et al. | Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. | 2009 Mar-Apr | Allergy Asthma Proc | pmid:19118503 |
| Mrówczyńska L and Hägerstrand H | Platelet-activating factor interaction with the human erythrocyte membrane. | 2009 Sep-Oct | J. Biochem. Mol. Toxicol. | pmid:19827129 |
| Church MK | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. | 2010 | Br. J. Dermatol. | pmid:20819087 |
| Hasan AM et al. | Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. | 2010 | Int. Immunopharmacol. | pmid:20685403 |
| Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
| Asaka N et al. | Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets. | 2010 | Arzneimittelforschung | pmid:21117500 |
| Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
| Xu CL et al. | [Inhibitory effect of TBN on platelet aggregation in rabbit]. | 2010 | Zhong Yao Cai | pmid:21243778 |
| Chen S et al. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20367900 |
| Leoni G et al. | The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. | 2010 | Br. J. Pharmacol. | pmid:20331604 |
| Danker K et al. | Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane. | 2010 | Br. J. Pharmacol. | pmid:20331609 |
| Kajiwara N et al. | Activation of human mast cells through the platelet-activating factor receptor. | 2010 | J. Allergy Clin. Immunol. | pmid:20392487 |
| Corl CM et al. | Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. | 2010 | Vet. Immunol. Immunopathol. | pmid:20359754 |
| Shi C et al. | H2O2 and PAF mediate Abeta1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761. | 2010 | Neurochem. Int. | pmid:20362023 |
| Coy B ED et al. | The first diastereoselective synthesis of cinerins A-C, PAF-antagonistic macrophyllin-type bicyclo[3.2.1]octane neolignans, using a novel Pd-catalysed oxyarylation. | 2010 | Org. Biomol. Chem. | pmid:20401372 |
| Ritter JM | Novel targets and regulatory ordeal by QT interval. | 2010 | Br J Clin Pharmacol | pmid:20406216 |
| Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
| Prokosch V et al. | Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592227 |
| Morimoto R et al. | Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. | 2010 | J. Biol. Chem. | pmid:20663880 |
| Balestrieri ML et al. | Endothelial progenitor cells express PAF receptor and respond to PAF via Ca(2+)-dependent signaling. | 2010 | Biochim. Biophys. Acta | pmid:20637897 |
| Karasuyama H et al. | Role for basophils in systemic anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519883 |
| Sanz ML et al. | In vitro diagnosis of anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519886 |
| Sharma J et al. | Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse. | 2010 | Biochemistry | pmid:20521843 |
| Cerkiene Z et al. | Immune factors in human embryo culture and their significance. | 2010 | Medicina (Kaunas) | pmid:20571290 |
| Adamson RH et al. | Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. | 2010 | Cardiovasc. Res. | pmid:20542878 |
| Liu SH et al. | Protection of carbon monoxide intraperitoneal administration from rat intestine injury induced by lipopolysaccharide. | 2010 | Chin. Med. J. | pmid:20497711 |
| Shin SH et al. | Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063106 |