Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Epilepsy D004827 35 associated lipids
Seizures D012640 87 associated lipids
Nerve Degeneration D009410 53 associated lipids
Birth Weight D001724 23 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Hypertension D006973 115 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Nasal Polyps D009298 26 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Ear Diseases D004427 7 associated lipids
Hypersensitivity, Immediate D006969 14 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Leukemia, Experimental D007942 42 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Agranulocytosis D000380 7 associated lipids
Shock D012769 11 associated lipids
Polycythemia Vera D011087 13 associated lipids
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Shock, Septic D012772 11 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Conjunctivitis D003231 7 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Death, Sudden D003645 12 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Neutropenia D009503 15 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Meningioma D008579 11 associated lipids
Multiple Trauma D009104 2 associated lipids
Cluster Headache D003027 4 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Behcet Syndrome D001528 7 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Migraine Disorders D008881 11 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Ramesha CS et al. Identification and quantitation of PAF from psoriatic scales. 1987 Agents Actions pmid:3687590
Friedlander G et al. Renal effects of platelet-activating factor in the rat. 1987 Agents Actions pmid:3687594
Doyle SA et al. Further studies on the antinociceptive effects of delta 6-THC-7-oic acid. 1990 Agents Actions pmid:2178317
Northover AM Modification by some antagonists of the shape changes of venous endothelial cells in response to inflammatory agents in vitro. 1990 Agents Actions pmid:2111079
Mencia-Huerta JM et al. Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process? 1981 Agents Actions pmid:7053072
Archer CB et al. Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. 1985 Agents Actions pmid:3923788
Vargaftig BB Platelet-activating factor (PAF-acether) 1982 Agents Actions pmid:7164939
Lauri D et al. Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. 1986 Agents Actions pmid:3706054
Bette P and Bienvenue A Exchange of a spin-labeled analog of PAF-acether between micelles, serum albumin and model membranes. 1982 Agents Actions pmid:7164940
Lartigue-Mattei C et al. Pharmacokinetic study of PAF-acether. Preliminary results after the intravenous administration of a 3H-labelled product to the rabbit. 1982 Agents Actions pmid:7164941
Morgat JL et al. Radio-labelling of 1-O-alkyl, 2-O-acetyl, sn-glycero-3-phosphorylcholine, 1-O-(9,10-di3H)-octadecyl PAF-acether. 1982 Agents Actions pmid:7164942
Convert O et al. 1H NMR of PAF-acether: influence of solvent on its structure. 1982 Agents Actions pmid:7164943
Borrel MC et al. Additional techniques for the total synthesis of PAF-acether. 1982 Agents Actions pmid:7164944
Benveniste J et al. Release of platelet-activating factor (PAF-acether) and 2-lyso PAF-acether from three cell types. 1982 Agents Actions pmid:7164945
Morley J Platelet activating factor and asthma. 1986 Agents Actions pmid:3099555
Vargaftig BB et al. Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). 1980 Agents Actions pmid:7270336
Boughton-Smith NK et al. Actions of nitric oxide on the acute gastrointestinal damage induced by PAF in the rat. 1992 Agents Actions pmid:1279960
Trebien HA and Calixto JB Pharmacological evaluation of rat paw oedema induced by Bothrops jararaca venom. 1989 Agents Actions pmid:2660497
Perret BA et al. Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. 1981 Agents Actions pmid:6803540
Denburg JA et al. Platelet activating factor: regulation by mast cells and aspirin. 1984 Agents Actions pmid:6711391
Pirotzky E et al. Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. 1985 Agents Actions pmid:4003192
Page CP et al. Platelet activating factor (Paf-acether) may account for late-onset reactions to allergen inhalation. 1985 Agents Actions pmid:4003195
Page CP et al. Suppression of Paf-acether responses: an anti-inflammatory effect of anti-asthma drugs. 1985 Agents Actions pmid:4003196
Spicer BA et al. An investigation of the involvement of platelet activating factor in the non-histamine immediate hypersensitivity reaction in the rat peritoneal cavity. 1985 Agents Actions pmid:4003197
Adnot S et al. Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. 1987 Agents Actions pmid:3115070
Tubaro E et al. In vitro and in vivo impact of a new glycosphingolipid on neutrophils. 1994 Agents Actions pmid:7879694
Canale P et al. TCV-309, a novel platelet activating factor antagonist, inhibits leukocyte accumulation and protects against splanchnic artery occlusion shock. 1994 Agents Actions pmid:7879698
Bussolino F et al. Chick retina generates platelet-activating factor. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2890284
Desquand S et al. Interference of the PAF-acether antagonist BN 52021 with anaphylaxis in the guinea pig. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2445183
Whittle BJ et al. Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959063
Montrucchio G et al. In vitro oxytocic activity of platelet-activating factor on human myometrium. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960158
Mallet AI et al. Platelet activating factor in chronic plaque psoriasis. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960170
Bourgain RH et al. Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960196
Braquet P et al. Platelet-activating factor: a potential mediator of shock. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960197
Myers A et al. Pharmacological manipulation of platelet-activating factor toxicity in rodents. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960198
Waku K et al. Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936199
Saito K et al. Determination of AGEPC generated from human neutrophils and rat skin and muscle tissues by a selected ion monitoring technique of GC/MS. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936200
Hanahan DJ et al. Platelet-activating factor: a unique lipid chemical mediator. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936201
Inoue K et al. Activation of guinea pig peritoneal macrophages by platelet-activating factor in free form or incorporated into liposomes. 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2936203
Izumi T et al. Regulation and signal transduction of PAF receptor. 1995 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7732892
Bennett SA and Birnboim HC Platelet activating factor induces transformation of human fibroblasts. 1995 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:7732893
Vargaftig BB et al. Synergized activation of human platelets by epinephrine and platelet-activating factor-acether is adenosine diphosphate and thromboxane A2-independent. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221558
Voelkel NF et al. Platelet-activating factor causes pulmonary vasoconstriction and edema via platelet-independent leukotriene formation. 1983 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:6221590
Benveniste J Paf-acether (platelet-activating factor). 1985 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:3159192
Benveniste J PAF-acether (platelet-activating factor). 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526498
Hsueh W and Sun XM Tumor necrosis factor-induced bowel necrosis: the role of platelet-activating factor. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526499
Pignol B et al. Effect of chronic administration of platelet-activating factor (PAF) in the guinea-pig and the rat. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526500
Foegh ML et al. Platelet-activating factor in organ transplant rejection. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526501
Pickett WC and Ramesha C Modulation of mediator precursors by changes in essential fatty acid composition. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2526546
Dray F et al. Recent studies on icosanoids and PAF-acether modulation of some central neurosecretions in the rat. 1989 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2546391