Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Konger RL et al. | Oxidized glycerophosphocholines as biologically active mediators for ultraviolet radiation-mediated effects. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18555720 |
| Fang H et al. | Toxoplasma gondii-derived heat shock protein 70 induces lethal anaphylactic reaction through activation of cytosolic phospholipase A2 and platelet-activating factor via Toll-like receptor 4/myeloid differentiation factor 88. | 2008 | Microbiol. Immunol. | pmid:18667035 |
| Sánchez FA et al. | Internalization of eNOS via caveolae regulates PAF-induced inflammatory hyperpermeability to macromolecules. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18708444 |
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| Si J et al. | STAT5 mediates PAF-induced NADPH oxidase NOX5-S expression in Barrett's esophageal adenocarcinoma cells. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:17947454 |
| Aomatsu K et al. | Toll-like receptor agonists stimulate human neutrophil migration via activation of mitogen-activated protein kinases. | 2008 | Immunology | pmid:17662043 |
| Lu YY et al. | Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis. | 2008 | World J. Gastroenterol. | pmid:18205269 |
| Nomura DK et al. | Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification. | 2008 | Toxicol. Appl. Pharmacol. | pmid:18164358 |
| O' Meara CM et al. | Relationship between in vitro sperm functional tests and in vivo fertility of rams following cervical artificial insemination of ewes with frozen-thawed semen. | 2008 | Theriogenology | pmid:18248736 |
| Sakellariou M et al. | Intravenous infusion of PAF affects ovulation, fertilization and preimplantation embryonic development in NZB x NZW F1 hybrid mice. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18248752 |
| Yuhki K et al. | Prostaglandin I2 plays a key role in zymosan-induced mouse pleurisy. | 2008 | J. Pharmacol. Exp. Ther. | pmid:18256172 |
| Chia YC et al. | Antiplatelet aggregation coumarins from the leaves of Murraya omphalocarpa. | 2008 | Molecules | pmid:18259135 |
| Kasperska-Zajac A et al. | Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. | 2008 | Inflammation | pmid:18193345 |
| Caprani A et al. | Preliminary study of pulsed-electromagnetic fields effects on endothelial (HUVEC) cell secretions--modulation of the thrombo-hemorrhagic balance. | 2008 | Electromagn Biol Med | pmid:19037787 |
| Satoh K | [Plasma platelet-activating factor acetylhydrolase (PAF-AH) deficiency as a risk factor for stroke]. | 2008 | Brain Nerve | pmid:19069165 |
| Hemetsberger R et al. | Association between the efficacy of dual antiplatelet therapy and the development of in-stent neointimal hyperplasia in porcine coronary arteries. | 2008 | Coron. Artery Dis. | pmid:19005299 |
| Tsujimura Y et al. | Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis. | 2008 | Immunity | pmid:18342553 |
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| Zhang Y et al. | Glycosides from the bark of Adina polycephala. | 2008 | J. Nat. Prod. | pmid:18303851 |
| Tsuchiya R et al. | Characterization of canine platelet activation induced by platelet activating factor (PAF). | 2008 | J. Vet. Med. Sci. | pmid:18319579 |
| Song W et al. | Pyridinium alkaloid-coupled secoiridoids from the flower buds of Lonicera japonica. | 2008 | J. Nat. Prod. | pmid:18321056 |
| Shiva D et al. | High dose of lipopolysaccharide pre-treatment prevents OVA-induced anaphylactic decreases in rectal temperature in the immunized mice. | 2008 | Immunol. Lett. | pmid:18433880 |
| Leary PJ et al. | A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18441203 |
| Berry KA et al. | Effects of acrolein on leukotriene biosynthesis in human neutrophils. | 2008 | Chem. Res. Toxicol. | pmid:19548361 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Vadnais ML et al. | Current concepts of molecular events during bovine and porcine spermatozoa capacitation. | 2007 May-Jun | Arch. Androl. | pmid:17612869 |
| Rosenwasser L | New insights into the pathophysiology of allergic rhinitis. | 2007 Jan-Feb | Allergy Asthma Proc | pmid:17390750 |
| De Vriese C et al. | Ghrelin interacts with human plasma lipoproteins. | 2007 | Endocrinology | pmid:17289852 |
| Li SQ et al. | Improving effect of Ginkgolide B on mitochondrial respiration of ischemic neuron after cerebral thrombosis in tree shrewa. | 2007 | Chin. Med. J. | pmid:17908463 |
| Doublier S et al. | The proangiogenic phenotype of tumor-derived endothelial cells is reverted by the overexpression of platelet-activating factor acetylhydrolase. | 2007 | Clin. Cancer Res. | pmid:17908960 |
| Shimada T et al. | Cross-regulation of cortisol secretion by adrenocorticotropin and platelet-activating factor in perfused guinea pig adrenals. | 2007 | J. Endocrinol. | pmid:17911394 |
| Whitehead SN et al. | Identification and quantitation of changes in the platelet activating factor family of glycerophospholipids over the course of neuronal differentiation by high-performance liquid chromatography electrospray ionization tandem mass spectrometry. | 2007 | Anal. Chem. | pmid:17949058 |
| Bixby CE et al. | Role of platelet-activating factor in pulmonary vascular remodeling associated with chronic high altitude hypoxia in ovine fetal lambs. | 2007 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:17951313 |
| Liu WC et al. | Lipopolysaccharide-induced cerebral inflammatory damage and the therapeutic effect of platelet activating factor receptor antagonist. | 2007 | Neurosci Bull | pmid:17952135 |
| Wu B et al. | [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:17953818 |
| Owen JS et al. | Platelet-activating factor. | 2007 | Meth. Enzymol. | pmid:17954244 |
| Ying-fang S et al. | Effect of platelet-activating factor on cell proliferation & NF-kappaB activation in airway smooth muscle cells in rats. | 2007 | Indian J. Med. Res. | pmid:17932440 |
| Guerra CT et al. | Effect of chronic hepatitis C virus infection on inflammatory lipid mediators. | 2007 | Dig Liver Dis | pmid:17936229 |
| Wang S et al. | Opposite effects of WEB2086 on angiogenesis in atheromas and ischemic hindlimb of apoE gene deficient mice. | 2007 | Chin. Med. J. | pmid:17543178 |
| Kulkarni S et al. | Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading. | 2007 | Blood | pmid:17548580 |
| Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
| Witzenrath M et al. | Role of platelet-activating factor in pneumolysin-induced acute lung injury. | 2007 | Crit. Care Med. | pmid:17522574 |
| Keles GC et al. | Levels of gingival tissue platelet activating factor after conventional and regenerative periodontal surgery. | 2007 | Clin Oral Investig | pmid:17522901 |
| Ebihara S et al. | A simple preparation method for mouse eosinophils and their responses to anti-allergic drugs. | 2007 | Inflamm. Res. | pmid:17406808 |
| Simonenko VB et al. | [Comparative evaluation of the influence of sulfhydryl and phosphate ACE inhibitors on thrombocyte aggregation in patients suffering from atrerial hypertension with metabolic syndrome]. | 2007 | Klin Med (Mosk) | pmid:17564032 |
| Li Y et al. | Autocrine activation of ion currents in the two-cell mouse embryo. | 2007 | Exp. Cell Res. | pmid:17583695 |
| Martin J et al. | The dialogue between endothelial cells and monocytes/macrophages in vascular syndromes. | 2007 | Curr. Pharm. Des. | pmid:17584105 |
| Ferreira MA et al. | Tumor growth, angiogenesis and inflammation in mice lacking receptors for platelet activating factor (PAF). | 2007 | Life Sci. | pmid:17588613 |
| Xia SH et al. | Significance of platelet activating factor receptor expression in pancreatic tissues of rats with severe acute pancreatitis and effects of BN52021. | 2007 | World J. Gastroenterol. | pmid:17589953 |
| Tosaki T et al. | Enhancement of acetyl-CoA: 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity by hydrogen peroxide. | 2007 | Biol. Pharm. Bull. | pmid:17268064 |
| Zhang X et al. | Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. | 2007 | Neurochem. Res. | pmid:17268849 |
| Sandford RM et al. | The genetic basis of abdominal aortic aneurysms: a review. | 2007 | Eur J Vasc Endovasc Surg | pmid:17276705 |
| Slomiany BL and Slomiany A | Interference by leptin with Helicobacter pylori lipopolysaccharide-induced cytosolic phospholipase A2 activation in gastric mucosal cells. | 2007 | J. Physiol. Pharmacol. | pmid:17440231 |
| Ullrich SE | Sunlight and skin cancer: lessons from the immune system. | 2007 | Mol. Carcinog. | pmid:17443748 |
| Richter M et al. | Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17448648 |
| Finnegan EM et al. | Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17483236 |
| Cattaneo M et al. | Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. | 2007 | Haematologica | pmid:17488697 |
| Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
| Kooyman FN et al. | Antibodies elicited by the bovine lungworm, Dictyocaulus viviparus, cross-react with platelet-activating factor. | 2007 | Infect. Immun. | pmid:17606606 |
| Dupré DJ et al. | Inverse agonist-induced signaling and down-regulation of the platelet-activating factor receptor. | 2007 | Cell. Signal. | pmid:17609120 |
| Huang QY and Li MJ | [Effect of platelet-activating factor on sperm function]. | 2007 | Zhonghua Nan Ke Xue | pmid:17615981 |
| Orr Y et al. | Conformational activation of CD11b without shedding of L-selectin on circulating human neutrophils. | 2007 | J. Leukoc. Biol. | pmid:17675559 |
| Bozlu G et al. | Platelet-activating factor antagonist (ABT-491) decreases neuronal apoptosis in neonatal rat model of hypoxic ischemic brain injury. | 2007 | Brain Res. | pmid:17320823 |
| Zhou W et al. | Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17322418 |
| Tsutsumi T et al. | Movement of monoglyceride derived from hydrolysis of fluorescence-labeled lyso platelet-activating factor by lysophospholipase C through plasma membranes of porcine kidney epithelial cell line LLC-PK1. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259070 |
| Viergutz T and Löhrke B | Role of the platelet-activating factor and its receptor in the proliferative regulation of bovine ovarian granulosa cells. | 2007 | Cell Prolif. | pmid:18021181 |
| Chen Q et al. | The yeast acylglycerol acyltransferase LCA1 is a key component of Lands cycle for phosphatidylcholine turnover. | 2007 | FEBS Lett. | pmid:17996202 |
| Ezoulin MJ et al. | A new acetylcholinesterase inhibitor with anti-PAF activity modulates oxidative stress and pro-inflammatory mediators release in stimulated RAW 264.7 macrophage cells. Comparison with tacrine. | 2007 | Int. Immunopharmacol. | pmid:17996678 |
| Xavier RG et al. | Enhanced platelet aggregation and activation under conditions of hypothermia. | 2007 | Thromb. Haemost. | pmid:18064324 |
| Dunkel B et al. | Platelet activation in ponies with airway inflammation. | 2007 | Equine Vet. J. | pmid:18065316 |
| Lu SM et al. | The phospholipid mediator platelet-activating factor mediates striatal synaptic facilitation. | 2007 | J Neuroimmune Pharmacol | pmid:18040844 |
| Rockel N et al. | The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression. | 2007 | J. Immunol. | pmid:17785795 |
| Li J et al. | Pharmacological profile of PMS777, a new AChE inhibitor with PAF antagonistic activity. | 2007 | Int. J. Neuropsychopharmacol. | pmid:16426477 |
| Bock J et al. | Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function. | 2007 | World J. Gastroenterol. | pmid:17876892 |
| Ryan SD et al. | Platelet activating factor-induced neuronal apoptosis is initiated independently of its G-protein coupled PAF receptor and is inhibited by the benzoate orsellinic acid. | 2007 | J. Neurochem. | pmid:17877634 |
| Madsen NJ et al. | Influence of preparative procedures on assay of platelet function and apparent effects of antiplatelet agents. | 2007 | Am. J. Cardiol. | pmid:17697836 |
| Tsoupras AB et al. | Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. | 2007 | Mediators Inflamm. | pmid:17710109 |
| Melnikova V and Bar-Eli M | Inflammation and melanoma growth and metastasis: the role of platelet-activating factor (PAF) and its receptor. | 2007 | Cancer Metastasis Rev. | pmid:17721743 |
| Lo GK et al. | What is the potential for overdiagnosis of heparin-induced thrombocytopenia? | 2007 | Am. J. Hematol. | pmid:17722079 |
| Chen J et al. | Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. | 2007 | J. Lipid Res. | pmid:17693621 |
| Shi W et al. | [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309677 |
| Kuckleburg CJ et al. | Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation. | 2007 | Infect. Immun. | pmid:17118985 |
| Ibe BO et al. | Platelet-activating factor modulates activity of cyclic nucleotides in fetal ovine pulmonary vascular smooth muscle. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17085546 |
| Saluk-Juszczak J et al. | The effect of lipopolysaccharide from Proteus mirabilis on the level of the stable end metabolic products of nitric oxide in blood platelets. | 2007 | Curr. Microbiol. | pmid:17160361 |
| Huang YH et al. | Suppression effect of seminal vesicle autoantigen on platelet-activating factor-induced mouse sperm capacitation. | 2007 | J. Cell. Biochem. | pmid:17131380 |
| Osborn TM et al. | Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17135294 |
| Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
| Bathgate R et al. | Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. | 2007 | Theriogenology | pmid:17157372 |
| Hammond A et al. | Platelets in equine recurrent airway obstruction. | 2007 | Res. Vet. Sci. | pmid:17107696 |
| Vinores SA et al. | TNF-alpha is critical for ischemia-induced leukostasis, but not retinal neovascularization nor VEGF-induced leakage. | 2007 | J. Neuroimmunol. | pmid:17107717 |
| Brkovic A and Sirois MG | Vascular permeability induced by VEGF family members in vivo: role of endogenous PAF and NO synthesis. | 2007 | J. Cell. Biochem. | pmid:17115409 |
| Fragopoulou E et al. | Biological activity of acetylated phenolic compounds. | 2007 | J. Agric. Food Chem. | pmid:17199317 |
| Greinacher A | Too many hits in HIT? | 2007 | Am. J. Hematol. | pmid:17729242 |
| Gui C et al. | Understanding the regulation mechanisms of PAF receptor by agonists and antagonists: molecular modeling and molecular dynamics simulation studies. | 2007 | Proteins | pmid:17243151 |
| Ali A et al. | Essential role of platelet-activating factor in male reproduction: a review. | 2007 | Reprod. Biomed. Online | pmid:17298732 |
| Park EJ et al. | Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. | 2007 | Shock | pmid:17510604 |
| Young RE et al. | Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. | 2007 | Br. J. Pharmacol. | pmid:17471175 |
| Steel HC et al. | Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4. | 2007 | Clin. Exp. Immunol. | pmid:17683509 |
| Eckert RE and Jones SL | Regulation of VASP serine 157 phosphorylation in human neutrophils after stimulation by a chemoattractant. | 2007 | J. Leukoc. Biol. | pmid:17684042 |