Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Stoddart NR et al. | Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. | 2001 | Zygote | pmid:11510473 |
Yu P et al. | [A study on changes and its mechanisms of intestinal mucosal permeability after severe burn]. | 1996 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:9387456 |
Liu Y et al. | [The role and significance of PAF in the early pulmonary injury following burns combined with endotoxemia in rats]. | 1999 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:11501075 |
Zhang F | [Protective effect of a platelet activating factor antagonist in experimental liver injury]. | 1990 | Zhonghua Yi Xue Za Zhi | pmid:2171727 |
Ji Z et al. | [The role of platelet activating factor in mesenterioangial microcirculatory disturbance complicated with acute pancreatitis in rats]. | 1995 | Zhonghua Yi Xue Za Zhi | pmid:7780816 |
Xiao J et al. | [Effect of platelet activating factor receptor at spinal cord neurocyte membrane on secondary damage after spinal cord injury]. | 1996 | Zhonghua Yi Xue Za Zhi | pmid:8758444 |
Liu BJ et al. | [Effect of BN52021 on platelet activating factor induced aggregation of psoriatic polymorphonuclear neutrophils]. | 1994 | Zhonghua Yi Xue Za Zhi | pmid:7994650 |
Zeng N | [Determination of plasma level of platelet activating factor in cirrhotic patients and its relation to endotoxemia]. | 1992 | Zhonghua Yi Xue Za Zhi | pmid:1319804 |
Chen SH | [Purification and some properties of platelet aggregating protein (PAP) from the plasma of a patient with thrombotic thrombocytopenic purpura]. | 1989 | Zhonghua Yi Xue Za Zhi | pmid:2598093 |
Wang CP et al. | [Influence of platelet activating factor and its antagonist on portal hypertension associated with liver cirrhosis: an experiment with rats]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16409839 |
Yu P et al. | [Pathogenetic effect of platelet activating factor on enterogenic endotoxemia after burn]. | 1999 | Zhonghua Yi Xue Za Zhi | pmid:11601022 |
Ma X et al. | [Corneal epithelial wound healing is delayed by platelet activating factor treatment]. | 2004 | Zhonghua Yan Ke Za Zhi | pmid:15307983 |
Qin X et al. | [The effect of platelet-activating factor antagonists on early bacteria translocation of rat after burn injury]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:7587673 |
Ji Z et al. | [The role of platelet activating factor in pathogenesis of acute pancreatitis in dogs]. | 1997 | Zhonghua Wai Ke Za Zhi | pmid:10374489 |
Xiao J et al. | [Effects of platelet activating factor and platelet activating factor receptor antagonist on spinal cord blood flow after spinal cord injury]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8762548 |
Yu P et al. | [The roles of platelet activating factor in intestinal mucosal barrier injury after burn]. | 1995 | Zhonghua Wai Ke Za Zhi | pmid:8565724 |
Han E et al. | [Effect of chronic antiplatelet treatment on platelet activating factor-induced platelet activity in stroke]. | 1991 | Zhonghua Shen Jing Jing Shen Ke Za Zhi | pmid:1868762 |
Yu HP et al. | [Experimental and clinical study of activated platelet in allergic asthma]. | 1991 | Zhonghua Nei Ke Za Zhi | pmid:1806336 |
Wang ZY | [Advances in the physiopathology of platelets]. | 1984 | Zhonghua Nei Ke Za Zhi | pmid:6099795 |
Shi H et al. | [Effects of a platelet-activating factor antagonist ONO-6240 on antigen induced eosinophil infiltration into the airways]. | 1995 | Zhonghua Nei Ke Za Zhi | pmid:8731847 |
Ren G and Ye R | [Changes in urinary excretion of platelet activating factor and its significance in patients with primary nephrotic syndrome]. | 1996 | Zhonghua Nei Ke Za Zhi | pmid:9275622 |
Huang QY and Li MJ | [Effect of platelet-activating factor on sperm function]. | 2007 | Zhonghua Nan Ke Xue | pmid:17615981 |
Chou CT et al. | Neutrophil chemiluminescence and superoxide production in patients with rheumatoid arthritis: the effect of zymosan, phorbol myristate acetate and platelet-activating factor. | 1991 | Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi | pmid:1667989 |
Cheng DY and Chen WB | [The current status of the research on platelet activating factor and pulmonary hypertension]. | 1993 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:8403064 |
Tu W et al. | [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. | 2000 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:11372382 |
Zhou X et al. | [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. | 1996 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:9387483 |
Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
Li Q | [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. | 1992 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1307517 |
Wang C et al. | [Inhalation of platelet-activating factor induced guinea pig airway hyperresponsiveness: role of eosinophils activation]. | 1995 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:8565083 |
Zhang S et al. | [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. | 1996 | Zhonghua Fu Chan Ke Za Zhi | pmid:9206185 |
Jiang W et al. | [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:22333285 |
Wang F et al. | [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9596897 |
Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
Wu B et al. | [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. | 2007 | Zhonghua Er Ke Za Zhi | pmid:17953818 |
Huang LG et al. | [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:22932017 |
Lu H and Xue XD | [Platelet-activating factor and neonatal necrotizing enterocolitis]. | 2004 | Zhonghua Er Ke Za Zhi | pmid:15189692 |
Li XJ et al. | [Expression of platelet-activating factor in necrotizing enterocolitis and its clinical significance]. | 2011 | Zhonghua Bing Li Xue Za Zhi | pmid:21426810 |
Zang BX et al. | [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506296 |
Wang WJ et al. | [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. | 2000 | Zhongguo Zhong Yao Za Zhi | pmid:12525061 |
Cheng NN and Ma YM | [A hypotensive analog of platelet-activating factor (PAF) in pheretima]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8011088 |
Shi W et al. | [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. | 2007 | Zhongguo Zhong Yao Za Zhi | pmid:18309677 |
Li SH et al. | [Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2619897 |
Li XG and Luo HM | [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617488 |
Chen ZN et al. | [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8216803 |
Chen ZN | [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8274205 |
Dong JC et al. | [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:10322836 |
Dong JC et al. | [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. | 1995 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:8704427 |
Zhang J et al. | [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475720 |
Wang J et al. | [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15143716 |
Chen WM et al. | [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12584792 |