| MeSH term | MeSH ID | Detail |
|---|---|---|
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Noguchi K et al. | The detection of platelet-activating factor in inflamed human gingival tissue. | 1989 | Arch. Oral Biol. | pmid:2783040 |
| Wainwright CL et al. | The effects of PAF antagonists on arrhythmias and platelets during acute myocardial ischaemia and reperfusion. | 1989 | Eur. Heart J. | pmid:2468494 |
| Lippe IT and Holzer P | The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle. | 1989 | Eur. J. Pharmacol. | pmid:2468509 |
| Etienne A et al. | Modulation by drugs of eosinophil recruitment induced by immune challenge in the rat. Possible roles of interleukin 5 and platelet-activating factor. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2468617 |
| Cirino G et al. | Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. | 1989 | Proc. Natl. Acad. Sci. U.S.A. | pmid:2470103 |
| Bregestovski PD and Ryan US | Voltage-gated and receptor-mediated ionic currents in the membrane of endothelial cells. | 1989 | J. Mol. Cell. Cardiol. | pmid:2471836 |
| Merritt JE et al. | Use of manganese to discriminate between calcium influx and mobilization from internal stores in stimulated human neutrophils. | 1989 | J. Biol. Chem. | pmid:2536366 |
| Kester M et al. | Beta-adrenergic inhibition of AGEPC-stimulated Na+/Ca2+ exchange and AGEPC-induced platelet activation. | 1989 | Biochim. Biophys. Acta | pmid:2554977 |
| Korth R et al. | Interaction of the Paf antagonist WEB 2086 and its hetrazepine analogues with human platelets and endothelial cells. | 1989 | Br. J. Pharmacol. | pmid:2555017 |
| Chao W et al. | Regulation of platelet-activating factor receptors in rat Kupffer cells. | 1989 | J. Biol. Chem. | pmid:2555359 |
| Travers JB et al. | Identification of functional platelet-activating factor receptors in Raji lymphoblasts. | 1989 | J. Immunol. | pmid:2555416 |
| Hosford D et al. | Platelet-activating factor and cytokine interactions in shock. | 1989 | Resuscitation | pmid:2555874 |
| Widdicombe JH et al. | Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. | 1989 | Am. J. Physiol. | pmid:2514604 |
| Yoshida N et al. | Pathogenesis of platelet-activating factor-induced gastric mucosal damage in rats. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2556790 |
| Stengel PW and Silbaugh SA | Reversal of A23187-induced airway constriction in the guinea pig. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2495351 |
| Wey HE | Phorbol diester enhances calcium ionophore A23187-induced [3H]acetate incorporation into platelet-activating factor in murine macrophages: predominant incorporation into 1-O-acyl-2-acetyl-sn-glycero-3-phosphocholine. | 1989 | J. Cell. Biochem. | pmid:2496135 |
| Stewart AG et al. | Evidence for an intracellular action of platelet-activating factor in bovine cultured aortic endothelial cells. | 1989 | Br. J. Pharmacol. | pmid:2497920 |
| Cucala M et al. | Central regulation of gastric acid secretion by platelet-activating factor in anesthesized rats. | 1989 | Prostaglandins | pmid:2499013 |
| Lomazova KD et al. | [The thrombocyte-activation factor and endotoxin-induced thrombocyte activation]. | 1989 | Biull Eksp Biol Med | pmid:2500157 |
| Kajiyama Y et al. | Pertussis toxin-sensitive GTP-binding proteins may regulate phospholipase A2 in response to thrombin in rabbit platelets. | 1989 | Arch. Biochem. Biophys. | pmid:2505676 |
| Record M et al. | Subcellular localization of phospholipids and enzymes involved in PAF-acether metabolism. | 1989 | J. Cell. Biochem. | pmid:2506197 |
| Warren JS et al. | Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat. | 1989 | J. Clin. Invest. | pmid:2536403 |
| Kurihara K et al. | Inhibition of platelet-activating factor (PAF)-induced chemotaxis and PAF binding to human eosinophils and neutrophils by the specific ginkgolide-derived PAF antagonist, BN 52021. | 1989 | J. Allergy Clin. Immunol. | pmid:2536413 |
| Hwang SB et al. | Characterization of platelet-activating factor (PAF) receptor by specific binding of [3H]L-659,989, a PAF receptor antagonist, to rabbit platelet membranes: possible multiple conformational states of a single type of PAF receptors. | 1989 | Mol. Pharmacol. | pmid:2536468 |
| Sirén AL and Feuerstein G | Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats. | 1989 | Am. J. Physiol. | pmid:2546449 |
| Bazill GW and Dexter TM | An antagonist to platelet activating factor counteracts the tumoricidal action of alkyl lysophospholipids. | 1989 | Biochem. Pharmacol. | pmid:2536543 |
| Barzaghi G and Mong S | Platelet activating factor-amidophosphonate (PAF-AP), a partial agonist inhibited platelet activating factor-induced calcium mobilization in human monocytic leukemic U-937 cell. | 1989 | Life Sci. | pmid:2536882 |
| Snyder F | Biochemistry of platelet-activating factor: a unique class of biologically active phospholipids. | 1989 | Proc. Soc. Exp. Biol. Med. | pmid:2536942 |
| Remuzzi G | Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. | 1989 | Adv. Exp. Med. Biol. | pmid:2696353 |
| Henson PM | PAF--a perspective. | 1989 | Am. J. Respir. Cell Mol. Biol. | pmid:2696514 |
| Pirotzky E et al. | Involvement of platelet-activating factor in renal processes. | 1989 | Adv. Lipid Res. | pmid:2698054 |
| Hampel G et al. | Selenium deficiency inhibits prostacyclin release and enhances production of platelet activating factor by human endothelial cells. | 1989 | Biochim. Biophys. Acta | pmid:2512981 |
| Snyder F et al. | Platelet-activating factor and related ether lipid mediators. Biological activities, metabolism, and regulation. | 1989 | Ann. N. Y. Acad. Sci. | pmid:2698076 |
| Okubo K et al. | The existence of a platelet-activating factor (Paf-acether)-like substance in blister fluid derived from patients with bullous pemphigoid as demonstrated by human platelet aggregation techniques. | 1989 | Kurume Med J | pmid:2700767 |
| Johnson RA et al. | An asymmetric synthesis of (R) and (S)-1-alkoxy-2,3-propanediols including precursors to platelet activating factor. | 1989 | Chem. Phys. Lipids | pmid:2766428 |
| McCulloch RK et al. | Role of thromboxane A2 as a mediator of platelet-activating-factor-induced aggregation of human platelets. | 1989 | Clin. Sci. | pmid:2758765 |
| Denizot Y et al. | Synthesis of paf-acether from exogenous precursors by the prokaryote Escherichia coli. | 1989 | FEBS Lett. | pmid:2646144 |
| Dembinska-Kiec A et al. | Release of cysteinyl leukotrienes is of minor importance in platelet-activating factor-induced reduction of perfusion rate in the rat gastric vascular bed. | 1989 | Prog. Clin. Biol. Res. | pmid:2798459 |
| dos Santos OF et al. | Effect of platelet-activating factor antagonist on cyclosporine nephrotoxicity. Glomerular hemodynamics evaluation. | 1989 | Transplantation | pmid:2705209 |
| Neuwirth R et al. | Extra- and intracellular metabolism of platelet-activating factor by cultured mesangial cells. | 1989 | Am. J. Physiol. | pmid:2705543 |
| Christman BW and Blair IA | Analysis of platelet activating factor in human saliva by gas chromatography/mass spectrometry. | 1989 | Biomed. Environ. Mass Spectrom. | pmid:2706378 |
| Varol FG et al. | Platelet-activating factor stimulates phosphatidylinositol hydrolysis in the rat myometrium. | 1989 | Eur. J. Pharmacol. | pmid:2707303 |
| Harper MJ et al. | Spermicidal effect of antagonists of platelet-activating factor. | 1989 | Fertil. Steril. | pmid:2707465 |
| Danyoshi C et al. | Pyrrolidine derivatives as inhibitors of platelet aggregation induced by platelet activating factor. | 1989 | Chem. Pharm. Bull. | pmid:2805179 |
| Macpherson JL et al. | Occurrence of platelet-activating factor (PAF) and an endogenous inhibitor of platelet aggregation in diffuse cutaneous mastocytosis. | 1989 | Clin. Exp. Immunol. | pmid:2805409 |
| McCormack DG et al. | Evidence against a role for platelet-activating factor in hypoxic pulmonary vasoconstriction in the rat. | 1989 | Clin. Sci. | pmid:2805602 |
| Salem P et al. | Presence of paf-acether in human thymus. | 1989 | FEBS Lett. | pmid:2806565 |
| Ryan US | Endothelium as a transducing surface. | 1989 | J. Mol. Cell. Cardiol. | pmid:2543830 |
| Straube W | [Early embryonal signals]. | 1989 | Zentralbl Gynakol | pmid:2665388 |
| Carveth HJ et al. | Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2665743 |
| Sánchez Crespo M | Biosynthesis of platelet-activating factor: the role of the remodeling pathway. | 1989 | Methods Find Exp Clin Pharmacol | pmid:2666805 |
| Kaminker AJ and Carreras LO | [Physiopathology of thrombotic microangiopathy]. | 1989 | Sangre (Barc) | pmid:2667170 |
| Mizushima H et al. | Purification of rabbit platelet secretory phospholipase A2 and its characteristics. | 1989 | J. Biochem. | pmid:2668261 |
| Badr KF et al. | Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. | 1989 | Am. J. Physiol. | pmid:2912165 |
| Hong JL et al. | [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2561935 |
| Benedetto C et al. | Reduced serum inhibition of platelet-activating factor activity in preeclampsia. | 1989 | Am. J. Obstet. Gynecol. | pmid:2912073 |
| Bazill GW and Dexter TM | Platelet activating factor antagonist L-652,731 inhibits thymidine transport. | 1989 | Biochem. Pharmacol. | pmid:2914023 |
| Petty AC and Scrutton MC | Platelet aggregation in whole blood: is the response to adrenaline, 5-hydroxytryptamine and PAF a direct consequence of stimulation by these agonists? | 1989 | Thromb. Res. | pmid:2749609 |
| VornovitskiÄ EG et al. | [Cardiodepressive effect of platelet activating factor]. | 1989 | Biull Eksp Biol Med | pmid:2914168 |
| Gallin EK | Evidence for a Ca-activated inwardly rectifying K channel in human macrophages. | 1989 | Am. J. Physiol. | pmid:2750892 |
| Palmantier R et al. | Biosynthesis of paf-acether. XIV. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2751666 |
| Ontell SJ et al. | Pharmacologic modulation of experimental postischemic hepatic function. | 1989 | Ann. Surg. | pmid:2916864 |
| Gelas P et al. | Differential activation by fMet-Leu-Phe and phorbol ester of a plasma membrane phosphatidylcholine-specific phospholipase D in human neutrophil. | 1989 | FEBS Lett. | pmid:2753160 |
| Filep J et al. | Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2916986 |
| Tilley JW et al. | Biphenylcarboxamide derivatives as antagonists of platelet-activating factor. | 1989 | J. Med. Chem. | pmid:2754708 |
| Camoratto AM and Grandison L | Platelet-activating factor stimulates prolactin release from dispersed rat anterior pituitary cells in vitro. | 1989 | Endocrinology | pmid:2917522 |
| Guthrie RW et al. | Pentadienyl carboxamide derivatives as antagonists of platelet-activating factor. | 1989 | J. Med. Chem. | pmid:2754709 |
| Straube W | [Which signals of early pregnancy are known currently, what cer- tainty have they and exactly how far are they applicable in practice?]. | 1989 | Zentralbl Gynakol | pmid:2655355 |
| Takayasu M et al. | Endothelin-induced mobilization of Ca2+ and the possible involvement of platelet activating factor and thromboxane A2. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2655596 |
| Pretolani M et al. | From anti-asthma drugs to PAF-acether antagonism and back. Present status. | 1989 | Biochem. Pharmacol. | pmid:2655601 |
| Esplugues JV and Whittle BJ | Gastric effects of PAF. | 1989 | Methods Find Exp Clin Pharmacol | pmid:2657290 |
| Miadonna A et al. | Evidence of PAF-acether metabolic pathway activation in antigen challenge of upper respiratory airways. | 1989 | Am. Rev. Respir. Dis. | pmid:2546468 |
| Camussi G et al. | Tumor necrosis factor stimulates human neutrophils to release leukotriene B4 and platelet-activating factor. Induction of phospholipase A2 and acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase activity and inhibition by antiproteinase. | 1989 | Eur. J. Biochem. | pmid:2546764 |
| Armstead WM et al. | Permissive role of prostanoids in acetylcholine-induced cerebral vasoconstriction. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2532248 |
| Spina D et al. | The role of platelet activating factor in allergic inflammation. | 1989 | Pulm Pharmacol | pmid:2520484 |
| Rosenthal MD et al. | Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils. | 1989 | Biochim. Biophys. Acta | pmid:2536283 |
| Teles de Araújo A et al. | Surfactant modifications and lipidic mediators in occupational lung diseases. | 1989 | Sarcoidosis | pmid:2623375 |
| Tomioka K et al. | YM461, a PAF antagonist, blocks antigen-induced late airway responses and airway hyperresponsiveness in allergic sheep. | 1989 | Eur. J. Pharmacol. | pmid:2620695 |
| Benfenati E et al. | Development of a mass spectrometric method to quantitate platelet activating factor in mouse urine. | 1989 | J. Lipid Res. | pmid:2621424 |
| Sueoka K et al. | In-vivo and in-vitro determination of components of rabbit early pregnancy factors. | 1989 | J. Reprod. Fertil. | pmid:2621714 |
| Marx MH et al. | Darmstoff analogues. 3. Actions of choline esters of acetal phosphatidic acids on visceral smooth muscle. | 1989 | J. Med. Chem. | pmid:2724301 |
| Tou JS | Platelet-activating factor regulates phospholipid metabolism in human neutrophils. | 1989 | Lipids | pmid:2586238 |
| Bradley LM et al. | Influence of thromboxane A2 receptor antagonism on pulmonary vasoconstrictor responses. | 1989 | Pediatr. Res. | pmid:2587116 |
| Smith D et al. | The effect of prophylactic anti-asthma drugs on PAF-induced platelet accumulation in the thorax of the guinea pig. | 1989 | Jpn. J. Pharmacol. | pmid:2593374 |
| Sanjar S et al. | Inhibition of PAF-induced eosinophil accumulation in pulmonary airways of guinea pigs by anti-asthma drugs. | 1989 | Jpn. J. Pharmacol. | pmid:2593375 |
| Iwai A et al. | Role of PAF in ischemia-reperfusion injury in the rat stomach. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595310 |
| Binnaka T et al. | Gastric mucosal damage induced in rats by intravenous administration of platelet-activating factor. | 1989 | Scand. J. Gastroenterol. Suppl. | pmid:2595311 |
| Bradley LM et al. | Circulatory effects of PAF-acether in newborn piglets. | 1989 | Am. J. Physiol. | pmid:2912183 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Saxena SP et al. | Histamine formed in stimulated human platelets is cytoplasmic. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803292 |
| Ormerod AD et al. | Effects of alprazolam on platelet activating factor-induced wealing. | 1989 | Br. J. Dermatol. | pmid:2803963 |
| PAF antagonists in asthma. | 1989 | Lancet | pmid:2564116 | |
| Küster LJ and Frölich JC | PAF-induced platelet aggregation and TXB2 formation. | 1989 | Thromb. Res. | pmid:2922704 |
| Randriamampita C and Trautmann A | Biphasic increase in intracellular calcium induced by platelet-activating factor in macrophages. | 1989 | FEBS Lett. | pmid:2544447 |
| Uhl D | [Platelet activating factor and platelet activating factor antagonists. New methods in asthma therapy?]. | 1989 | Med Monatsschr Pharm | pmid:2544789 |
| Neiman J et al. | Platelet responses to platelet-activating factor are inhibited in alcoholics undergoing alcohol withdrawal. | 1989 | Thromb. Res. | pmid:2617478 |
| Chau LY et al. | Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2545193 |
| Thierry A et al. | Presence of specific platelet-activating factor binding sites in the rat retina. | 1989 | Eur. J. Pharmacol. | pmid:2545464 |
| Kraemer R and Mullane KM | Neutrophils delay functional recovery of the post-hypoxic heart of the rabbit. | 1989 | J. Pharmacol. Exp. Ther. | pmid:2553929 |
| Ichikawa Y et al. | [Effect of glycyrrhizin on the production of platelet-activating factor from rat peritoneal exudate cells]. | 1989 | Arerugi | pmid:2783037 |