| MeSH term | MeSH ID | Detail |
|---|---|---|
| Reperfusion Injury | D015427 | 65 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Weight Loss | D015431 | 56 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Parkinson Disease | D010300 | 53 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Osteosarcoma | D012516 | 50 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Espey LL et al. | Decrease in ovarian platelet-activating factor during ovulation in the gonadotropin-primed immature rat. | 1989 | Biol. Reprod. | pmid:2804200 |
| Orlov SM et al. | [Mechanism of suppression of human peripheral blood lymphocyte proliferation by platelet activation factor]. | 1989 | Biull Eksp Biol Med | pmid:2804305 |
| O'Neill C et al. | Supplementation of in-vitro fertilisation culture medium with platelet activating factor. | 1989 | Lancet | pmid:2476641 |
| VornovitskiÄ EG et al. | [Interactions of PAF and its antagonists in the guinea pig atrial myocardium]. | 1989 | Biull Eksp Biol Med | pmid:2804312 |
| Bekemeier H and Sänze JU | Vasodepression ex vivo after administration of inflammatory mediators in vivo in the rat. | 1989 | Agents Actions | pmid:2476918 |
| Tkachuk VA et al. | Receptor-operated channels in human platelets. | 1989 | J. Protein Chem. | pmid:2477022 |
| Muirhead EE et al. | Biologic contrasts between medullipin I and vasoactive glyceryl compounds. | 1989 | Am. J. Med. Sci. | pmid:2764021 |
| Silva PM et al. | Late eosinophil mobilization induced by PAF-acether in the pleural cavity of rats. | 1989 | Braz. J. Med. Biol. Res. | pmid:2638199 |
| Yeo YK et al. | The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543394 |
| Nakashima S et al. | Mechanism of arachidonic acid liberation in platelet-activating factor-stimulated human polymorphonuclear neutrophils. | 1989 | J. Immunol. | pmid:2545786 |
| Denizot Y and Benveniste J | [Contamination of fermented milk products by proinflammatory autacoid paf-acether]. | 1989 | C. R. Acad. Sci. III, Sci. Vie | pmid:2510911 |
| Aglietta M et al. | [GM-CSF: target cells and their response kinetics]. | 1989 | Haematologica | pmid:2512230 |
| Sturk A et al. | Synthesis of platelet-activating factor by human blood platelets and leucocytes. Evidence against selective utilization of cellular ether-linked phospholipids. | 1989 | Biochim. Biophys. Acta | pmid:2512985 |
| Gomez-Cambronero J et al. | Calcium is necessary but not sufficient for the platelet-activating factor release in human neutrophils stimulated by physiological stimuli. Role of G-proteins. | 1989 | J. Biol. Chem. | pmid:2513317 |
| Reinhold SL et al. | Phospholipid remodeling in human neutrophils. Parallel activation of a deacylation/reacylation cycle and platelet-activating factor synthesis. | 1989 | J. Biol. Chem. | pmid:2513324 |
| Squinto SP et al. | Platelet-activating factor stimulates a fos/jun/AP-1 transcriptional signaling system in human neuroblastoma cells. | 1989 | J. Neurosci. Res. | pmid:2513416 |
| DiCorleto PE and de la Motte CA | Thrombin causes increased monocytic-cell adhesion to endothelial cells through a protein kinase C-dependent pathway. | 1989 | Biochem. J. | pmid:2513808 |
| Chao W et al. | Metabolism of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by cultured rat Kupffer cells. | 1989 | Biochem. J. | pmid:2775221 |
| Touvay C et al. | Effect of cyclosporin A and the platelet-activating factor (PAF) antagonist, BN 52021, on PAF- and antigen- induced bronchoconstriction in the guinea-pig. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2775253 |
| Leyravaud S and Benveniste J | Regulation of cellular retention of paf-acether by extracellular pH and cell concentration. | 1989 | Biochim. Biophys. Acta | pmid:2775773 |
| Shukla SD et al. | Desensitization of platelet-activating factor-stimulated protein phosphorylation in platelets. | 1989 | Mol. Pharmacol. | pmid:2539556 |
| Franzone JS et al. | Doxofylline exerts a prophylactic effect against bronchoconstriction and pleurisy induced by PAF. | 1989 | Eur. J. Pharmacol. | pmid:2776832 |
| Montrucchio G et al. | Release of platelet-activating factor from ischemic-reperfused rabbit heart. | 1989 | Am. J. Physiol. | pmid:2539755 |
| Gasser H et al. | Effect of platelet-activating factor (PAF) administration in chronically instrumented sheep--analysis of PAF in plasma. | 1989 | Prog. Clin. Biol. Res. | pmid:2780708 |
| Pretolani M et al. | PAF-acether and experimental anaphylaxis as a model for asthma. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2540093 |
| Bonavida B et al. | The involvement of platelet-activating factor (PAF)-induced monocyte activation and tumor necrosis factor (TNF) production in shock. | 1989 | Prog. Clin. Biol. Res. | pmid:2780710 |
| Heuer H | Effect of a new and specific PAF-antagonist, WEB 2086, on PAF and endotoxin/tumor necrosis factor induced changes in mortality and intestinal transit velocity. | 1989 | Prog. Clin. Biol. Res. | pmid:2780739 |
| Mandi Y et al. | Effect of the platelet-activating factor antagonist BN 52021 on human natural killer cell cytotoxicity. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2540096 |
| Weber KH and Heuer H | Structure-activity relationships and effects of platelet-activating factor antagonists in the hetrazepine series. | 1989 | Int. Arch. Allergy Appl. Immunol. | pmid:2540098 |
| Lopez Diez F et al. | Occupancy of platelet receptors for platelet-activating factor in patients with septicemia. | 1989 | J. Clin. Invest. | pmid:2540221 |
| Wirthmueller U et al. | Platelet-activating factor production in human neutrophils by sequential stimulation with granulocyte-macrophage colony-stimulating factor and the chemotactic factors C5A or formyl-methionyl-leucyl-phenylalanine. | 1989 | J. Immunol. | pmid:2540238 |
| O'Flaherty JT et al. | Bidirectional effects of protein kinase C activators. Studies with human neutrophils and platelet-activating factor. | 1989 | J. Biol. Chem. | pmid:2540163 |
| Stewart AG and Phillips WA | Intracellular platelet-activating factor regulates eicosanoid generation in guinea-pig resident peritoneal macrophages. | 1989 | Br. J. Pharmacol. | pmid:2553184 |
| Woodward DF et al. | Platelet-activating factor causes goblet cell depletion in the conjunctiva. | 1989 | Eur. J. Pharmacol. | pmid:2555201 |
| Filipponi F et al. | Prolongation of guinea pig-to-rat xenograft survival with BN 52063, a specific antagonist of platelet-activating factor. | 1989 | Ital J Surg Sci | pmid:2483404 |
| Sanchez Crespo M and Nieto ML | Modulation of PAF biosynthesis in human polymorphonuclear leukocytes. The role of phorbol esters and protein kinases. | 1989 | Agents Actions | pmid:2711927 |
| Zijlstra FJ et al. | The effects of PAF-acether and FMLP on eicosanoid production in guinea pig alveolar macrophages. | 1989 | Agents Actions | pmid:2711928 |
| Nijkamp FP et al. | Role of platelet activating factor in the endotoxin induced tracheal hyperreactivity to histamine in the guinea pig. | 1989 | Agents Actions | pmid:2711929 |
| Benveniste J | PAF-acether (platelet-activating factor). | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526498 |
| Oliver JL et al. | Effect of PAF acether on oriented egg phosphatidylcholine multibilayers; interaction with cholesterol; comparison to lyso-PC and lyso-PAF. | 1989 | Agents Actions | pmid:2711930 |
| Hsueh W and Sun XM | Tumor necrosis factor-induced bowel necrosis: the role of platelet-activating factor. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2526499 |
| Capron M | Eosinophils: receptors and mediators in hypersensitivity. | 1989 | Clin. Exp. Allergy | pmid:2713741 |
| Cirino G and Wallace JL | A superfusion bioassay for platelet-activating factor. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2713756 |
| Levy C et al. | High affinity acceptor sites in guinea pig brain for [3H]52770 RP, a PAF antagonist. | 1989 | Fundam Clin Pharmacol | pmid:2714731 |
| Suematsu M et al. | In vivo visualization of oxyradical-dependent photoemission during endothelium-granulocyte interaction in microvascular beds treated with platelet-activating factor. | 1989 | J. Biochem. | pmid:2808326 |
| Hansel W et al. | Low molecular weight lipid-soluble luteotrophic factor(s) produced by conceptuses in cows. | 1989 | J. Reprod. Fertil. Suppl. | pmid:2810227 |
| Thatcher WW et al. | Antiluteolytic effects of bovine trophoblast protein-1. | 1989 | J. Reprod. Fertil. Suppl. | pmid:2810237 |
| Smal MA et al. | Production of antibodies to platelet activating factor. | 1989 | Mol. Immunol. | pmid:2811869 |
| Hemmendinger S et al. | Mitogenic activity on human arterial smooth muscle cells is increased in the plasma of patients undergoing hemodialysis with cuprophane membranes. | 1989 | Nephron | pmid:2812169 |
| Braquet P and Hosford D | The potential role of platelet-activating factor (PAF) in shock, sepsis and adult respiratory distress syndrome (ARDS). | 1989 | Prog. Clin. Biol. Res. | pmid:2675060 |
| Hermán F et al. | Decreased sensitivity of platelets to platelet-activating factor in migraine patients during the headache-free interval. | 1989 | Thromb. Haemost. | pmid:2814933 |
| Mencia-Hurerta JM et al. | The role of platelet-activating factor (PAF) in immune and cytotoxic processes. | 1989 | Prog. Clin. Biol. Res. | pmid:2675061 |
| Heuer H and Casals-Stenzel J | The pathophysiological role of PAF in anaphylactic lung reaction in the guinea pig and in endotoxin shock evidenced by the specific PAF-antagonist WEB 2086. | 1989 | Prog. Clin. Biol. Res. | pmid:2675077 |
| Godard P et al. | [Physiopathology of asthma]. | 1989 | Ann. Biol. Clin. (Paris) | pmid:2675684 |
| Lefer AM | Platelet activating factor (PAF) and its role in cardiac injury. | 1989 | Prog. Clin. Biol. Res. | pmid:2678133 |
| Page CP and Coyle AJ | The interaction between PAF, platelets and eosinophils in bronchial asthma. | 1989 | Eur Respir J Suppl | pmid:2679601 |
| McCusker MT et al. | Effect of topical capsaicin on the cutaneous responses to inflammatory mediators and to antigen in man. | 1989 | J. Allergy Clin. Immunol. | pmid:2471719 |
| Esplugues JV et al. | Local opioid-sensitive afferent sensory neurones in the modulation of gastric damage induced by Paf. | 1989 | Br. J. Pharmacol. | pmid:2758231 |
| Stanton AW et al. | Platelet-activating factor (Paf) antagonist, WEB 2086, protects against Paf-induced hypotension in Macaca fascicularis. | 1989 | Br. J. Pharmacol. | pmid:2758235 |
| Dixon EJ et al. | The effect of Paf antagonists on bronchial hyperresponsiveness induced by Paf, propranolol or indomethacin. | 1989 | Br. J. Pharmacol. | pmid:2758238 |
| Hébert RL et al. | Inhibition of platelet-activating factor induced renal hemodynamic and tubular dysfunctions with L-655,240, a new thromboxane-prostaglandin endoperoxide antagonist. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2758373 |
| Yaghi A et al. | Influence of platelet-activating factor on leukotriene D4-induced contractions of the guinea pig parenchymal strip. | 1989 | Can. J. Physiol. Pharmacol. | pmid:2758374 |
| Konturek SJ et al. | Role of leukotrienes and platelet activating factor in acute gastric mucosal lesions in rats. | 1989 | Eur. J. Pharmacol. | pmid:2759176 |
| Peterson JR et al. | Platelet activating factor antagonist design. 3. X-ray crystal structure and intermolecular crystal lattice interactions of methyl trans-4-acetoxymethyl-4,5-dihydro-2,5-bis(3,4-methylenedioxyphenyl)- 3-furancarboxylate. | 1989 | Acta Crystallogr C | pmid:2604943 |
| Lister MD et al. | Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide. | 1989 | J. Biol. Chem. | pmid:2498315 |
| Miyazaki H et al. | Lactone and cyclic ether analogues of platelet-activating factor. Synthesis and biological activities. | 1989 | Chem. Pharm. Bull. | pmid:2605681 |
| Miyazaki H et al. | Synthesis and antagonistic activities of enantiomers of cyclic platelet-activating factor analogues. | 1989 | Chem. Pharm. Bull. | pmid:2605682 |
| Fortes ZB et al. | Functional changes in the microcirculation of alloxan-induced diabetic rats. | 1989 | Gen. Pharmacol. | pmid:2606330 |
| Pletscher A et al. | LDL induced shape change reaction of platelets is not due to PAF. | 1989 | Thromb. Res. | pmid:2609294 |
| Han GQ et al. | [The isolation and identification of PAF inhibitors from Piper wallichii (Miq.) Hand-Mazz and P. hancei Maxim]. | 1989 | Yao Xue Xue Bao | pmid:2609983 |
| Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
| Bossant MJ et al. | Quantitation of paf-acether by release of endogenous platelet serotonin assessed by liquid chromatography with electrochemical detection. | 1989 | Anal. Biochem. | pmid:2610359 |
| Buckley TL and Hoult JR | Platelet activating factor is a potent colonic secretagogue with actions independent of specific PAF receptors. | 1989 | Eur. J. Pharmacol. | pmid:2542064 |
| Fitzgerald MF et al. | Release of PAF-acether and eicosanoids from guinea-pig alveolar macrophages by FMLP: effect of cyclo-oxygenase and lipoxygenase inhibition. | 1989 | Eur. J. Pharmacol. | pmid:2548873 |
| Zavoico GB et al. | IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis. | 1989 | J. Immunol. | pmid:2497185 |
| Munoz NM et al. | Evidence for platelet-activating factor secretion during immune activation in dogs. | 1989 | J. Appl. Physiol. | pmid:2732178 |
| Yanagihara Y et al. | Immunopharmacological studies on TBX, a new antiallergic drug (3). Inhibitory effects on histamine release from lung fragments and bronchoconstriction in guinea pigs. | 1989 | Jpn. J. Pharmacol. | pmid:2478743 |
| Leyravaud S et al. | Biosynthesis of paf-acether. X. Phorbol myristate acetate-induced paf-acether biosynthesis and acetyltransferase activation in human neutrophils. | 1989 | J. Immunol. | pmid:2732470 |
| Martiny-Baron G and Scherer GF | Phospholipid-stimulated protein kinase in plants. | 1989 | J. Biol. Chem. | pmid:2530218 |
| Joseph R et al. | Platelet-activating factor and red blood cells. | 1989 | Thromb. Res. | pmid:2734734 |
| Jackson SP and Salem HH | Platelet aggregating activity in the plasma of patients with established thrombosis. | 1989 | Aust N Z J Med | pmid:2504137 |
| Dubovsky SL et al. | Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. | 1989 | Arch. Gen. Psychiatry | pmid:2735813 |
| Rodrigues FA et al. | Hypothesis: a central role for platelet activating factor in the pathogenesis of pre-eclampsia. | 1989 | Med. Hypotheses | pmid:2739597 |
| Pirotzky E et al. | [Renal diseases and platelet activating factor]. | 1989 | Pediatrie | pmid:2740184 |
| Ng DS and Wong K | Effect of platelet-activating factor (PAF) on cytosolic free calcium in human peripheral blood mononuclear leukocytes. | 1989 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:2740622 |
| Baker RC et al. | Effects of ethanol on human platelets stimulated with platelet-activating factor, a biologically active ether phospholipid. | 1989 | Alcohol. Clin. Exp. Res. | pmid:2557776 |
| Stewart AG | CV 6209 is a non-competitive antagonist of platelet-activating factor receptors on guinea-pig resident peritoneal macrophages. | 1989 | Clin. Exp. Pharmacol. Physiol. | pmid:2558827 |
| Kudolo GB and Harper MJ | Characterization of platelet-activating factor binding sites on uterine membranes from pregnant rabbits. | 1989 | Biol. Reprod. | pmid:2559778 |
| Beyer CF et al. | Cryogenic induced ocular HSV-1 reactivation is enhanced by an inhibitor of the lipoxygenase pathway. | 1989 | Curr. Eye Res. | pmid:2560693 |
| VornovitskiÄ EG et al. | [The blocking action of platelet-activating factor (PAF) on the calcium currents of the atrial fibers in the frog and guinea pig]. | 1989 | Biull Eksp Biol Med | pmid:2561348 |
| Hoshikawa-Fujimura AY et al. | PAF-acether, superoxide anion and beta-glucuronidase as parameters of polymorphonuclear cell activation associated with cardiac surgery and cardiopulmonary bypass. | 1989 | Braz. J. Med. Biol. Res. | pmid:2561459 |
| Whatley RE et al. | The regulation of platelet-activating factor production in endothelial cells. The role of calcium and protein kinase C. | 1989 | J. Biol. Chem. | pmid:2703492 |
| Handley DA et al. | Chemistry and pharmacology of PAF antagonists. Evaluation of changes at potential metabolism sites on activity and duration of activity. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546390 |
| Dray F et al. | Recent studies on icosanoids and PAF-acether modulation of some central neurosecretions in the rat. | 1989 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2546391 |
| Alonso MT et al. | Monitoring of the activation of receptor-operated calcium channels in human platelets. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2546547 |
| Remy E et al. | Inhibition of platelet-activating factor biosynthesis via the acetyltransferase by arachidonic and oleic acids in ionophore A23187-stimulated bovine neutrophils. | 1989 | Biochim. Biophys. Acta | pmid:2505852 |
| Kroegel C et al. | Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2546554 |
| O'Flaherty JT et al. | Receptor-independent metabolism of platelet-activating factor by myelogenous cells. | 1989 | FEBS Lett. | pmid:2546802 |
| Yoshikawa T et al. | [Role of polymorphonuclear leukocytes and oxygen-derived free radicals in the formation of gastric mucosal lesions induced by platelet-activating factor]. | 1989 | Nihon Shokakibyo Gakkai Zasshi | pmid:2547098 |
| Beume R and Kilian U | [The significance of platelet activating factor and its antagonists in bronchial asthma]. | 1989 | Med. Klin. (Munich) | pmid:2547143 |