| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Edema | D001929 | 20 associated lipids |
| Brain Injuries | D001930 | 4 associated lipids |
| Bronchial Diseases | D001982 | 3 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Bronchopulmonary Dysplasia | D001997 | 4 associated lipids |
| Bronchopulmonary Sequestration | D001998 | 3 associated lipids |
| Burns | D002056 | 34 associated lipids |
| Burns, Inhalation | D002059 | 4 associated lipids |
| Carbon Monoxide Poisoning | D002249 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ozaki Y et al. | Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: evaluation of acetyltransferase activity. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3687329 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Ponpipom MM et al. | Structure-activity relationships of kadsurenone analogues. | 1987 | J. Med. Chem. | pmid:3027330 |
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
| Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
| Ramesha CS and Pickett WC | Human neutrophil platelet-activating factor: molecular heterogeneity in unstimulated and ionophore-stimulated cells. | 1987 | Biochim. Biophys. Acta | pmid:3113489 |
| Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
| Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
| Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
| Kurosawa M | Effect of platelet activating factor on histamine release from rat mast cells. | 1987 | Agents Actions Suppl. | pmid:2445185 |
| Gerard NP | Characterization of substance P contractile activity on isolated guinea pig lung tissues. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447271 |
| Beijer L et al. | The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig. | 1987 | Br. J. Pharmacol. | pmid:2447993 |
| Belch JJ et al. | Whole blood white cell aggregation: a novel technique. | 1987 | Thromb. Res. | pmid:2448894 |
| Barrio V et al. | Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor. | 1987 | Eur. J. Pharmacol. | pmid:2952517 |
| Camussi G et al. | Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin. | 1987 | J. Lab. Clin. Med. | pmid:2955066 |
| Casals-Stenzel J | Protective effect of WEB 2086, a novel antagonist of platelet activating factor, in endotoxin shock. | 1987 | Eur. J. Pharmacol. | pmid:3582490 |
| Fouque F and Vargaftig BB | Potentiation and inhibition by clonidine of PAF-acether-induced human platelet activation. | 1987 | Eur. J. Pharmacol. | pmid:3582495 |
| Lellouch-Tubiana A et al. | Interactions between granulocytes and platelets with the guinea-pig lung in passive anaphylactic shock. Correlations with PAF-acether-induced lesion. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3583412 |
| Patterson R et al. | Evaluation of the effect of a platelet activating factor antagonist on platelet activating factor and Ascaris antigen-induced airway responses in rhesus monkeys. | 1987 | J. Lab. Clin. Med. | pmid:3668360 |
| Stewart AG and Piper PJ | Actions of platelet-activating factor in the coronary circulation of the guinea pig in vitro. | 1987 | Prog. Clin. Biol. Res. | pmid:3671383 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| O'Flaherty JT et al. | 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820395 |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Wymann MP et al. | Oscillatory motion in human neutrophils responding to chemotactic stimuli. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820398 |
| Myers AK and Bader TJ | Role of adrenal steroids in the recovery from platelet activating factor challenge. | 1987 | Circ. Shock | pmid:3677334 |
| Hsueh W et al. | Platelet-activating factor: an endogenous mediator for bowel necrosis in endotoxemia. | 1987 | FASEB J. | pmid:3678700 |
| Woodard DS et al. | The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. | 1987 | J. Biol. Chem. | pmid:3029085 |
| Edwards MC et al. | Secretion and properties of a polypeptide factor generated by phorbol ester stimulation of human blood platelets. | 1987 | Biochem. Pharmacol. | pmid:3606649 |
| Sturk A et al. | Age-related deficiency of the synthesis of platelet activating factor by leukocytes from Zellweger patients. | 1987 | Blood | pmid:3607283 |
| Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Low-temperature fluorescence emission changes in thylakoids induced by acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | Arch. Biochem. Biophys. | pmid:3813566 |
| Martins MA et al. | Interactions between local inflammatory and systemic haematological effects of PAF-acether in the rat. | 1987 | Eur. J. Pharmacol. | pmid:3609124 |
| Mangold HK et al. | Biologically active lipids. Semi-synthesis of 3H-labeled ether glycerophospholipids and ether glyceroglycolipids from ratfish liver oil. | 1987 | FEBS Lett. | pmid:3609315 |
| Caffrey E et al. | Aggregation responses to platelet-activating factor in normal subjects. | 1987 | Haemostasis | pmid:3609916 |
| Baer PG and Cagen LM | Platelet activating factor vasoconstriction of dog kidney. Inhibition by alprazolam. | 1987 | Hypertension | pmid:3818022 |
| Bittman R et al. | Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone. | 1987 | J. Lipid Res. | pmid:3611974 |
| Terashita Z et al. | CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivo. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3612533 |
| Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
| Tokumura A et al. | Platelet aggregation induced by ether-linked phospholipids. 1. Inhibitory actions of bovine serum albumin and structural analogues of platelet activating factor. | 1987 | Thromb. Res. | pmid:3647677 |
| Rola-Pleszczynski M et al. | Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3493773 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Dewald B and Baggiolini M | Evaluation of PAF antagonists using human neutrophils in a microtiter plate assay. | 1987 | Biochem. Pharmacol. | pmid:3649232 |
| Adler KB et al. | Platelet activating factor stimulates secretion of mucin by explants of rodent airways in organ culture. | 1987 | Exp. Lung Res. | pmid:3653044 |
| Nakayama R et al. | Existence of endogenous inhibitors of platelet-activating factor (PAF) with PAF in rat uterus. | 1987 | J. Biol. Chem. | pmid:3654606 |
| Taylor RR et al. | Whole blood platelet aggregation is not affected by cigarette smoking but is sex-related. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:3440324 |
| Shimazaki N et al. | Diketopiperazines as a new class of platelet-activating factor inhibitors. | 1987 | J. Med. Chem. | pmid:3656347 |
| Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Heinsohn C et al. | The effect of bovine serum albumin on the synthesis of prostaglandin and incorporation of [3H]acetate into platelet-activating factor. | 1987 | Arch. Biochem. Biophys. | pmid:3662526 |
| Knox P et al. | Role of plasminogen, plasmin, and plasminogen activators in the migration of fibroblasts into plasma clots. | 1987 | J. Cell. Physiol. | pmid:2958486 |
| Sperling RI et al. | Effects of dietary supplementation with marine fish oil on leukocyte lipid mediator generation and function in rheumatoid arthritis. | 1987 | Arthritis Rheum. | pmid:3663263 |
| Danhauser S et al. | Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro. | 1987 | Lipids | pmid:3444384 |
| Oon SH and Williams N | Immature megakaryocytes in the mouse: synergistic response to megakaryocyte potentiator, thrombopoietic stimulatory factor with interleukin 3. | 1987 | Leukemia | pmid:3500375 |
| Pretolani M et al. | Interference by the novel PAF-acether antagonist WEB 2086 with the bronchopulmonary responses to PAF-acether and to active and passive anaphylactic shock in guinea-pigs. | 1987 | Eur. J. Pharmacol. | pmid:3653247 |
| Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
| Hurst JS et al. | Effects of the lipid peroxidation product 4-hydroxynonenal on the aggregation of human platelets. | 1987 | Chem. Biol. Interact. | pmid:3103933 |
| Grigorian GY and Ryan US | Platelet-activating factor effects on bovine pulmonary artery endothelial cells. | 1987 | Circ. Res. | pmid:3040294 |
| Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
| Morganroth ML et al. | Decreased pulmonary vascular responsiveness in rats raised on an essential fatty acid deficient diet. | 1987 | Prostaglandins | pmid:3108962 |
| Lamant V et al. | Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. | 1987 | Biochem. Pharmacol. | pmid:2820421 |
| Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
| Page CP and Robertson DN | Properties of PAF relevant to asthma. | 1987 | Agents Actions Suppl. | pmid:3314416 |
| Steel G et al. | Failure of prostaglandin E2 and its 16,16-dimethyl analogue to prevent the gastric mucosal damage induced by Paf. | 1987 | Br. J. Pharmacol. | pmid:3470106 |
| Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
| Morley J | PAF and airway hyperreactivity; prospects for novel prophylactic anti-asthma drugs. | 1987 | Agents Actions Suppl. | pmid:3314417 |
| Di Marzo V et al. | Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2822041 |
| Kimura Y et al. | Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:2825795 |
| Braquet P et al. | The role of PAF-acether in anaphylaxis demonstrated with the use of the antagonist BN 52021. | 1987 | Agents Actions Suppl. | pmid:3314418 |
| Rubin AH et al. | The bronchoconstrictor properties of platelet-activating factor in humans. | 1987 | Am. Rev. Respir. Dis. | pmid:3314611 |
| Vargaftig BB and Braquet PG | PAF-acether today--relevance for acute experimental anaphylaxis. | 1987 | Br. Med. Bull. | pmid:2825900 |
| Mathur RS et al. | Current concepts in asthma. | 1987 | J Assoc Physicians India | pmid:3320019 |
| Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
| Kelton JG and Murphy WG | Acute thrombocytopenia and thrombosis. Heparin-induced thrombocytopenia and thrombotic thrombocytopenic purpura. | 1987 | Ann. N. Y. Acad. Sci. | pmid:3322132 |
| Valone FH and Johnson B | Modulation of platelet-activating-factor-induced calcium influx and intracellular calcium release in platelets by phorbol esters. | 1987 | Biochem. J. | pmid:3322269 |
| Tamura N et al. | Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030295 |
| O'Flaherty JT | Phospholipid metabolism and stimulus-response coupling. | 1987 | Biochem. Pharmacol. | pmid:3030324 |
| Caramelo C et al. | Increased levels of platelet-activating factor in blood from patients with cirrhosis of the liver. | 1987 | Eur. J. Clin. Invest. | pmid:3106053 |
| Stahl GL et al. | PAF-acether induced cardiac dysfunction in the isolated perfused guinea pig heart. | 1987 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:3431598 |
| Spinnewyn B et al. | Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. | 1987 | Prostaglandins | pmid:3432553 |
| Guinot P et al. | Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study. | 1987 | Prostaglandins | pmid:3432562 |
| Ho YS et al. | Chemoattractant-induced activation of c-fos gene expression in human monocytes. | 1987 | J. Exp. Med. | pmid:3108444 |
| Hayashi M et al. | Detection of platelet-activating factor in exudates of rats with phorbol myristate acetate-induced pleurisy. | 1987 | Thromb. Res. | pmid:3433255 |
| Wymann MP et al. | The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process. | 1987 | J. Biol. Chem. | pmid:3040727 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Matsuno K et al. | [Cytoplasm free calcium ions as a second messenger]. | 1987 | Rinsho Byori | pmid:3437533 |
| Kawamura Y et al. | [A simple measurement of plasma platelet-activating factor (PAF) acetylhydrolase, normal level of activity, and distribution among lipoprotein fractions]. | 1987 | Rinsho Byori | pmid:3437547 |
| Kertscher HP and Ostermann G | [Synthesis and platelet aggregating activity of structural analogs of platelet-activating factor with a heterocyclic head group]. | 1987 | Pharmazie | pmid:3438334 |
| Maudsley DJ and Morris AG | Rapid intracellular calcium changes in U937 monocyte cell line: transient increases in response to platelet-activating factor and chemotactic peptide but not interferon-gamma or lipopolysaccharide. | 1987 | Immunology | pmid:3110054 |
| Lianos EA and Zanglis A | Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. | 1987 | J. Biol. Chem. | pmid:3110152 |
| Riedel A et al. | The effect of the specific PAF antagonist BN 52021 and the calcium blocker diltiazem on PAF induced arrhythmogenicity. | 1987 | Pharmacol Res Commun | pmid:3441484 |
| Bull HA and Machin SJ | The haemostatic function of the vascular endothelial cell. | 1987 | Blut | pmid:3111566 |
| Vane J and Botting R | Inflammation and the mechanism of action of anti-inflammatory drugs. | 1987 | FASEB J. | pmid:3111928 |
| Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |
| Szczeklik A et al. | Bleeding time and PAF-acether-induced platelet aggregation in atopy. | 1987 | Agents Actions Suppl. | pmid:3478996 |
| Schmitz-Schumann M et al. | Evidence of PAF release and platelet activation in analgesics-asthma-syndrome. | 1987 | Agents Actions Suppl. | pmid:3478999 |
| Guinot P et al. | Effects of BN 52063 on PAF-acether induced weal and flare in man. | 1987 | Agents Actions Suppl. | pmid:3479000 |
| Lang M et al. | Effects of the PAF-antagonist CV-3988 on PAF-induced changes in mucus secretion and in respiratory and circulatory variables in ferrets. | 1987 | Agents Actions Suppl. | pmid:3479001 |
| Codde JP et al. | Effects of altered prostanoid and lyso-PAF synthesis by marine oil diets on blood pressure of salt loaded spontaneously hypertensive rats. | 1987 | Agents Actions Suppl. | pmid:3481207 |
| Kurgan J | [Blood platelets and asthma and other lung diseases]. | 1987 | Pol Tyg Lek | pmid:3684765 |
| Ezra D et al. | Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. | 1987 | Prostaglandins | pmid:3685397 |