| MeSH term | MeSH ID | Detail |
|---|---|---|
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Encephalitis, Viral | D018792 | 3 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Pelvic Pain | D017699 | 7 associated lipids |
| Soft Tissue Injuries | D017695 | 2 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lemieux C et al. | Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. | 2005 | Blood | pmid:15498854 |
| Mishra RK et al. | Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K). | 2005 | Allergy | pmid:16076309 |
| Jin Y et al. | Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. | 2005 | Eur. J. Immunol. | pmid:16078278 |
| Meyer MC et al. | Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:16079184 |
| Fernandes ES et al. | Cytokines and neutrophils as important mediators of platelet-activating factor-induced kinin B1 receptor expression. | 2005 | Br. J. Pharmacol. | pmid:16025141 |
| Xie DS and Xie YT | [Role of platelet activating factor in hepatorenal syndrome]. | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16045031 |
| Marathe GK et al. | Ultraviolet B radiation generates platelet-activating factor-like phospholipids underlying cutaneous damage. | 2005 | J. Biol. Chem. | pmid:16115894 |
| Chang GT et al. | Purification and characterization of a new anticoagulant protein, PP27, from placenta. | 2005 | Thromb. Res. | pmid:16122555 |
| Ezoulin MJ et al. | Differential effect of PMS777, a new type of acetylcholinesterase inhibitor, and galanthamine on oxidative injury induced in human neuroblastoma SK-N-SH cells. | 2005 | Neurosci. Lett. | pmid:16095823 |
| Choi IW et al. | TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. | 2005 | J. Allergy Clin. Immunol. | pmid:16159621 |
| Burgos RA et al. | 14-deoxyandrographolide as a platelet activating factor antagonist in bovine neutrophils. | 2005 | Planta Med. | pmid:16041644 |
| Caplan MS et al. | The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. | 2005 | Semin. Pediatr. Surg. | pmid:16084401 |
| Denizot Y et al. | Platelet-activating factor and liver metastasis of colorectal cancer. | 2005 | Int. J. Cancer | pmid:15455343 |
| Shindou H et al. | Priming effect of lipopolysaccharide on acetyl-coenzyme A:lyso-platelet-activating factor acetyltransferase is MyD88 and TRIF independent. | 2005 | J. Immunol. | pmid:16002720 |
| Black S et al. | An intact phosphocholine binding site is necessary for transgenic rabbit C-reactive protein to protect mice against challenge with platelet-activating factor. | 2005 | J. Immunol. | pmid:16002722 |
| Koch E | Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: considerations on possible bleeding complications after oral intake of Ginkgo biloba extracts. | 2005 | Phytomedicine | pmid:15693702 |
| Jantan I et al. | Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. | 2005 | Phytomedicine | pmid:15693713 |
| El-Medany A et al. | Attenuation of bleomycin-induced lung fibrosis in rats by mesna. | 2005 | Eur. J. Pharmacol. | pmid:15713430 |
| Ninio E | Phospholipid mediators in the vessel wall: involvement in atherosclerosis. | 2005 | Curr Opin Clin Nutr Metab Care | pmid:15716789 |
| Evans L et al. | A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies. | 2005 | J. Pharm. Pharmacol. | pmid:15720781 |
| Yoshida H et al. | Platelet-activating factor enhances the expression of nerve growth factor in normal human astrocytes under hypoxia. | 2005 | Brain Res. Mol. Brain Res. | pmid:15661369 |
| Zhu L and He P | Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15665052 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Qu XW et al. | Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. | 2005 | Crit. Care Med. | pmid:15891335 |
| Gilli UO et al. | Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor. | 2005 | Transplantation | pmid:15912099 |
| Park EJ et al. | Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains. | 2005 | Glycobiology | pmid:15917432 |
| Owen JS et al. | Stress-induced platelet-activating factor synthesis in human neutrophils. | 2005 | Biochim. Biophys. Acta | pmid:15863359 |
| Göggel R and Uhlig S | The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema. | 2005 | Eur. Respir. J. | pmid:15863642 |
| MartÃnez-Cócera C et al. | Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomised, double-blind parallel study. | 2005 | J Investig Allergol Clin Immunol | pmid:15864879 |
| Yeh JH et al. | 2-O-methyl PAF as a Ca2+ mobilizer in Madin Darby canine kidney cells. | 2005 | Life Sci. | pmid:15878360 |
| Cheng L et al. | Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. | 2005 | Gastroenterology | pmid:16285965 |
| Medvedev IN and GromnatsiÄ NI | [The influence of nebivolol on thrombocyte aggregation in patients with arterial hypertension with metabolic sydrome]. | 2005 | Klin Med (Mosk) | pmid:15881638 |
| Rastelli VM et al. | Influence of insulin on the microvascular response to inflammatory mediators in neonatal streptozotocin diabetic rats. | 2005 | Inflamm. Res. | pmid:15883740 |
| Ko HM et al. | Involvement of matrix metalloproteinase-9 in platelet-activating factor-induced angiogenesis. | 2005 | FEBS Lett. | pmid:15848174 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Chen LW et al. | Different pathways leading to activation of extracellular signal-regulated kinase and p38 MAP kinase by formyl-methionyl-leucyl-phenylalanine or platelet activating factor in human neutrophils. | 2005 | J. Biomed. Sci. | pmid:15917990 |
| Goldring WP et al. | Novel phomactin analogues as PAF receptor ligands. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15922596 |
| Tombul T et al. | Hemostatic markers and platelet aggregation factors as predictive markers for type of stroke and neurological disability following cerebral infarction. | 2005 | J Clin Neurosci | pmid:15925775 |
| Boccellino M et al. | Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. | 2005 | Am. J. Pathol. | pmid:15855650 |
| Schram MT et al. | Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. | 2005 | Hypertension | pmid:15851628 |
| Denizot Y et al. | Platelet-activating factor and human thyroid cancer. | 2005 | Eur. J. Endocrinol. | pmid:15994743 |
| Androulakis N et al. | Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation. | 2005 | J. Lipid Res. | pmid:15995176 |
| Grypioti AD et al. | Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration. | 2005 | Arch. Toxicol. | pmid:15995853 |
| Chatterjee BE et al. | Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. | 2005 | J. Leukoc. Biol. | pmid:16000391 |
| Vinson SM et al. | Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15937147 |
| Sumita C et al. | Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. | 2005 | FEBS Lett. | pmid:16004986 |
| Dong J et al. | [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171322 |
| Ou-Yang XY et al. | [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. | 2005 | Yao Xue Xue Bao | pmid:16011257 |
| Estellés R et al. | Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. | 2005 | J. Leukoc. Biol. | pmid:15944212 |
| Zhao T and Bokoch GM | Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. | 2005 | J. Immunol. | pmid:15944312 |
| McLarnon JG et al. | Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients. | 2005 | J. Neurosci. Res. | pmid:15948178 |
| Ozger S et al. | Effects of platelet-activating factor on nitrergic transmission in rabbit corpus cavernosum. | 2005 | Int. J. Urol. | pmid:15985080 |
| Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
| Asada Y | [Inflammatory and immune responses in arterial thrombus formation]. | 2005 | Rinsho Ketsueki | pmid:16447700 |
| Kira J | [Multiple sclerosis]. | 2005 | Rinsho Shinkeigaku | pmid:16447761 |
| Rubin BB et al. | Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. | 2005 | J. Biol. Chem. | pmid:15475363 |
| Uhlig S et al. | Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. | 2005 | Pharmacol Rep | pmid:16415501 |
| Zinchuk O et al. | Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. | 2005 | Mol. Vis. | pmid:15735601 |
| Lang PA et al. | Stimulation of erythrocyte ceramide formation by platelet-activating factor. | 2005 | J. Cell. Sci. | pmid:15741229 |
| Sheppard FR et al. | Clinically relevant osmolar stress inhibits priming-induced PMN NADPH oxidase subunit translocation. | 2005 | J Trauma | pmid:15824651 |
| Leveau P et al. | Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant. | 2005 | Biochem. Pharmacol. | pmid:15826603 |
| Kumar S and Sharma A | Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. | 2005 | Theriogenology | pmid:15763101 |
| Asai Y | Formation of spherical micelles composed of the novel platelet activating factor receptor antagonist, E5880. | 2005 | Pharmazie | pmid:15801673 |
| Nacken W et al. | S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils. | 2005 | Int. J. Biochem. Cell Biol. | pmid:15778088 |
| Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
| Perry SW et al. | HIV-1 transactivator of transcription protein induces mitochondrial hyperpolarization and synaptic stress leading to apoptosis. | 2005 | J. Immunol. | pmid:15778398 |
| Ishiura Y et al. | In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789611 |
| Gaudreault E et al. | Involvement of leukotriene B4 receptor 1 signaling in platelet-activating factor-mediated neutrophil degranulation and chemotaxis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789613 |
| Calcerrada MC et al. | Selective translocation of protein kinase c isozymes by PAF in rabbit platelets. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15789614 |
| Hudry-Clergeon H et al. | Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. | 2005 | FASEB J. | pmid:15791001 |
| Ersoy B et al. | The role of platelet-activating factor in pathogenesis of type 1 diabetes. | 2005 | Diabetes Care | pmid:15793212 |
| Grigoriou O et al. | Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination. | 2005 | Fertil. Steril. | pmid:15749490 |
| Ivanov AI et al. | Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15576666 |
| Denizot Y et al. | Platelet-activating factor does not stimulate cAMP formation from immature forms of freshly isolated leukaemic blasts. | 2005 | Leuk. Lymphoma | pmid:15621790 |
| Meyer MC et al. | Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15643055 |
| Granger J and Remick D | Acute pancreatitis: models, markers, and mediators. | 2005 | Shock | pmid:16374372 |
| Wang CP et al. | [Influence of platelet activating factor and its antagonist on portal hypertension associated with liver cirrhosis: an experiment with rats]. | 2005 | Zhonghua Yi Xue Za Zhi | pmid:16409839 |
| Zhang Q et al. | Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. | 2005 | J. Clin. Invest. | pmid:16184199 |
| Pexa A and Deussen A | Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16200394 |
| Karantonis HC et al. | Synthesis and biological evaluation of novel steroid-modified ether phospholipids. | 2005 | Chem. Phys. Lipids | pmid:16202400 |
| Antonopoulou S et al. | Bioactive polar lipids from Chroococcidiopsis sp. (Cyanobacteria). | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:16198133 |
| Melo RC et al. | Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. | 2005 | Traffic | pmid:16138901 |
| Ueda Y et al. | Antianaphylactic and antipruritic effects of the flowers of Impatiens textori MIQ. | 2005 | Biol. Pharm. Bull. | pmid:16141562 |
| Chang GT et al. | Inhibitory effect of the Korean herbal medicine, Dae-Jo-Whan, on platelet-activating factor-induced platelet aggregation. | 2005 | J Ethnopharmacol | pmid:16125889 |
| Iversen VV et al. | Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. | 2005 | Acta Physiol. Scand. | pmid:16128692 |
| Hu G et al. | Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction. | 2005 | Anesth. Analg. | pmid:16243978 |
| Okumura N et al. | Platelet-activating factor in human normal tears. | 2005 | Curr. Eye Res. | pmid:16251126 |
| Ko HM et al. | Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line. | 2005 | FEBS Lett. | pmid:16288746 |
| Ward JR et al. | Agonists of toll-like receptor (TLR)2 and TLR4 are unable to modulate platelet activation by adenosine diphosphate and platelet activating factor. | 2005 | Thromb. Haemost. | pmid:16270639 |
| Walz PH et al. | Platelet function and association of bovine viral diarrhea virus with platelets of persistently infected cattle. | 2005 | Am. J. Vet. Res. | pmid:16273905 |
| Shargall Y et al. | Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part VI: treatment. | 2005 | J. Heart Lung Transplant. | pmid:16210120 |
| Fragopoulou E et al. | Characterization of acetyl-CoA: lyso-PAF acetyltransferase of human mesangial cells. | 2005 | Mediators Inflamm. | pmid:16258193 |
| Shibamoto T et al. | Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303618 |
| Vieira-de-Abreu A et al. | Anti-allergic properties of the bromeliaceae Nidularium procerum: inhibition of eosinophil activation and influx. | 2005 | Int. Immunopharmacol. | pmid:16275631 |
| Bellizzi MJ et al. | Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. | 2005 | J. Clin. Invest. | pmid:16276420 |
| Yu P et al. | Mitogen-activated protein kinases regulate platelet-activating factor-induced hyperpermeability. | 2005 | Microcirculation | pmid:16284005 |
| Buke AC et al. | Tumor necrosis factor alpha and interleukin 6 productions in response to platelet-activating factor in chronic hepatitis B virus infection. | 2004 Sep-Oct | Med Princ Pract | pmid:15316260 |
| Zang BX et al. | [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. | 2004 | Zhongguo Zhong Yao Za Zhi | pmid:15506296 |
| Roudebush WE et al. | Platelet-activating factor significantly enhances intrauterine insemination pregnancy rates in non-male factor infertility. | 2004 | Fertil. Steril. | pmid:15236989 |
| Naoki K et al. | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047169 |