| MeSH term | MeSH ID | Detail |
|---|---|---|
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Encephalitis, Viral | D018792 | 3 associated lipids |
| Pneumonia, Bacterial | D018410 | 16 associated lipids |
| Leukocyte-Adhesion Deficiency Syndrome | D018370 | 1 associated lipids |
| Respiratory Syncytial Virus Infections | D018357 | 10 associated lipids |
| Carcinoma, Embryonal | D018236 | 8 associated lipids |
| Pelvic Pain | D017699 | 7 associated lipids |
| Soft Tissue Injuries | D017695 | 2 associated lipids |
| Dermatitis, Allergic Contact | D017449 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
| Mayerle J et al. | [Conservative treatment of acute pancreatitis]. | 2003 | Med. Klin. (Munich) | pmid:14685675 |
| Tellis C et al. | Localization of an alkyl-acetyl-glycerol-CDP-choline: cholinephosphotransferase activity in submitochondrial fractions of Tetrahymena pyriformis. | 2003 | Eur. J. Cell Biol. | pmid:14703014 |
| Stafforini DM et al. | Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. | 2003 | Crit Rev Clin Lab Sci | pmid:14708958 |
| Narahara H et al. | Platelet-activating factor inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages. | 2003 | J. Clin. Endocrinol. Metab. | pmid:14671207 |
| Gálvez J et al. | The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. | 2003 | Inflamm. Bowel Dis. | pmid:14671485 |
| Saeed SA and Rasheed H | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | 2003 | Acta Pharmacol. Sin. | pmid:12511226 |
| Ishizuka S et al. | Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. | 2003 | J. Infect. Dis. | pmid:14673774 |
| Shen Z et al. | Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions. | 2003 | Planta Med. | pmid:12898414 |
| de Assis EF et al. | Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes. | 2003 | J. Immunol. | pmid:12902515 |
| Hu H et al. | Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. | 2003 | J. Thromb. Haemost. | pmid:12911597 |
| Kalia N and Bardhan KD | Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. | 2003 | J. Gastroenterol. Hepatol. | pmid:12911655 |
| Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
| Lupia E et al. | Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. | 2003 | Int. J. Mol. Med. | pmid:12883648 |
| Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
| Taggart DP et al. | Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. | 2003 | Heart | pmid:12860868 |
| Takafuji S et al. | Matrix metalloproteinase-9 release from human leukocytes. | 2003 | J Investig Allergol Clin Immunol | pmid:12861851 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Kujiraoka T et al. | Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. | 2003 | J. Lipid Res. | pmid:12867534 |
| D'Andrea D et al. | Induction of tissue factor in the arterial wall during recurrent thrombus formation. | 2003 | Arterioscler. Thromb. Vasc. Biol. | pmid:12869352 |
| Lupia E et al. | The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. | 2003 | Immunology | pmid:12871223 |
| Fernandes ES et al. | Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. | 2003 | Br. J. Pharmacol. | pmid:12839871 |
| Saruc M et al. | An experimental model of hemolysis-induced acute pancreatitis. | 2003 | Braz. J. Med. Biol. Res. | pmid:12845374 |
| Nomikos TN et al. | Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. | 2003 | Eur. J. Biochem. | pmid:12846832 |
| Suzuki M et al. | Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. | 2003 | J. Allergy Clin. Immunol. | pmid:12847489 |
| Casillan AJ et al. | Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. | 2003 | J. Appl. Physiol. | pmid:12598480 |
| Rios-Santos F et al. | A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. | 2003 | Shock | pmid:12558146 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
| Lukashova V et al. | Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. | 2003 | J. Immunol. | pmid:14500680 |
| Brandt EB et al. | Mast cells are required for experimental oral allergen-induced diarrhea. | 2003 | J. Clin. Invest. | pmid:14660743 |
| Rhee CK | Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide? | 2003 | Laryngoscope | pmid:14660903 |
| Diaper CM et al. | A total synthesis of (+/-)-phomactin A. | 2003 | Org. Biomol. Chem. | pmid:14664384 |
| Antonopoulou S et al. | Hydroxyl-platelet-activating factor exists in blood of healthy volunteers and periodontal patients. | 2003 | Mediators Inflamm. | pmid:14514473 |
| Gödecke A | PAF, PIP(3) and NO: emerging role in reperfusion injury. | 2003 | Cardiovasc. Res. | pmid:14613846 |
| Toledo DP et al. | Microvascular reactivity in experimental diabetes: responses of male and female rats. | 2003 | Inflamm. Res. | pmid:12813623 |
| Tonks AJ et al. | Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine. | 2003 | J. Leukoc. Biol. | pmid:12832447 |
| Choi IW et al. | Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. | 2003 | J. Exp. Med. | pmid:12835479 |
| Kell PJ et al. | Inhibition of platelet-activating factor (PAF) acetylhydrolase by methyl arachidonyl fluorophosphonate potentiates PAF synthesis in thrombin-stimulated human coronary artery endothelial cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:14560038 |
| Denizot Y et al. | Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. | 2003 | Oncogene | pmid:14562051 |
| Ivanov AI et al. | Platelet-activating factor: a previously unrecognized mediator of fever. | 2003 | J. Physiol. (Lond.) | pmid:14565987 |
| Proudfoot JM et al. | Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12626661 |
| Fang HY et al. | Cyclooxygenase-2 in human non-small cell lung cancer. | 2003 | Eur J Surg Oncol | pmid:12633561 |
| Cole KP and Hsung RP | Intramolecular formal oxa-[3 + 3] cycloaddition approach to the ABD system of phomactin A. | 2003 | Org. Lett. | pmid:14653688 |
| Hao J et al. | [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552687 |
| Witko-Sarsat V et al. | AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. | 2003 | Kidney Int. | pmid:12787398 |
| Elovitz MA et al. | A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. | 2003 | Am. J. Pathol. | pmid:14578208 |
| Slomiany BL and Slomiany A | Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788098 |
| Kogure K et al. | Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and their degradation product, lysophosphatidylcholine. | 2003 | Chem. Phys. Lipids | pmid:14580708 |
| Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
| Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
| Bernatchez PN et al. | Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | 2003 | J. Cell. Biochem. | pmid:14587028 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Denizot Y et al. | Platelet-activating factor and normal or leukaemic haematopoiesis. | 2003 | Leuk. Lymphoma | pmid:12802913 |
| Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
| Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
| Haraldsen P et al. | Multimodal management - of value in fulminant acute pancreatitis? | 2003 | Pancreatology | pmid:12649560 |
| Li XG and Luo HM | [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617488 |
| Denizot Y et al. | No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis. | 2003 | Mediators Inflamm. | pmid:12775360 |
| Yan W et al. | Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. | 2003 | Proc. Natl. Acad. Sci. U.S.A. | pmid:12775763 |
| Nie ZG and Wang WJ | [Effect of ginkgolide B on platelet-activating factor induced activation of rat polymorphonuclear leukocytes]. | 2003 | Yao Xue Xue Bao | pmid:12778742 |
| Fragopoulou E et al. | Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. | 2003 | Biochim. Biophys. Acta | pmid:12782155 |
| Marshall JC | Such stuff as dreams are made on: mediator-directed therapy in sepsis. | 2003 | Nat Rev Drug Discov | pmid:12750742 |
| Chatterjee SS et al. | Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. | 2003 | Pharmacopsychiatry | pmid:13130392 |
| Mahgoub AA | Thymoquinone protects against experimental colitis in rats. | 2003 | Toxicol. Lett. | pmid:12749817 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |
| Thaete LG et al. | Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. | 2003 | J. Soc. Gynecol. Investig. | pmid:12699876 |
| Simon HU et al. | Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. | 2003 | Eur. J. Immunol. | pmid:12672048 |
| Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
| Kordan W et al. | Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. | 2003 | Pol J Vet Sci | pmid:12675470 |
| Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |
| Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
| Peri A et al. | The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin. | 2003 | Hum. Cell | pmid:15005239 |
| Wu B et al. | Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. | 2003 | FASEB J. | pmid:12709415 |
| Ueda Y et al. | Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. | 2003 | Biol. Pharm. Bull. | pmid:14519965 |
| Akisu M et al. | The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. | 2003 | Ann. Nutr. Metab. | pmid:14520021 |
| Bussolati B et al. | The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. | 2003 | J. Immunol. | pmid:12538709 |
| Frostegård J et al. | Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. | 2003 | Am. J. Obstet. Gynecol. | pmid:14520236 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Ahlemeyer B and Krieglstein J | Neuroprotective effects of Ginkgo biloba extract. | 2003 | Cell. Mol. Life Sci. | pmid:14523543 |
| Hirayama K et al. | Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. | 2003 | Dis. Colon Rectum | pmid:12544529 |
| Balestrieri ML et al. | Modulation by flavonoids of PAF and related phospholipids in endothelial cells during oxidative stress. | 2003 | J. Lipid Res. | pmid:12576520 |
| Biancone L et al. | Platelet-activating factor inactivation by local expression of platelet-activating factor acetyl-hydrolase modifies tumor vascularization and growth. | 2003 | Clin. Cancer Res. | pmid:14519648 |
| Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
| Corl CM et al. | Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12615078 |
| Chen L et al. | [Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media]. | 2003 | Lin Chuang Er Bi Yan Hou Ke Za Zhi | pmid:14727433 |
| Dinarello CA | The IL-1 family and inflammatory diseases. | 2002 Sep-Oct | Clin. Exp. Rheumatol. | pmid:14989423 |
| Chłopicki S et al. | Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1. | 2002 Sep-Oct | Pol J Pharmacol | pmid:12593530 |
| Klabunde RE and Anderson DE | Role of nitric oxide and reactive oxygen species in platelet-activating factor-induced microvascular leakage. | 2002 May-Jun | J. Vasc. Res. | pmid:12097822 |
| Huang JB et al. | Hexokinase translocation during neutrophil activation, chemotaxis, and phagocytosis: disruption by cytochalasin D, dexamethasone, and indomethacin. | 2002 Jul-Aug | Cell. Immunol. | pmid:12470617 |
| Levine AS et al. | A review of the effect of platelet-activating factor on male reproduction and sperm function. | 2002 Jul-Aug | J. Androl. | pmid:12065449 |
| Farbiszewski R et al. | [The role of platelet activating factor (PAF) in physiology and pathology of the central nervous system]. | 2002 Jul-Aug | Neurol. Neurochir. Pol. | pmid:12418143 |
| Teather LA et al. | Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. | 2002 | Psychopharmacology (Berl.) | pmid:12373444 |
| Baker PR et al. | Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. | 2002 | Biochim. Biophys. Acta | pmid:12379481 |
| McLennan SV et al. | Effects of mesangium glycation on matrix metalloproteinase activities: possible role in diabetic nephropathy. | 2002 | Diabetes | pmid:12145178 |
| Claud EC et al. | Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers. | 2002 | Pediatr. Res. | pmid:12149490 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Kato T et al. | Mitochondrial calcium response in human transformed lymphoblastoid cells. | 2002 | Life Sci. | pmid:12052442 |
| Sakamoto H et al. | Overexpression of phospholipid hydroperoxide glutathione peroxidase modulates acetyl-CoA, 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase activity. | 2002 | J. Biol. Chem. | pmid:12397078 |
| Ichinowatari G et al. | Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6. | 2002 | Eur. J. Pharmacol. | pmid:11779582 |
| Rivera A et al. | Modulation of Gardos channel activity by cytokines in sickle erythrocytes. | 2002 | Blood | pmid:11756192 |