Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
Prunieras M | Melanocytes, melanogenesis, and inflammation. | 1986 | Int. J. Dermatol. | pmid:2433237 |
Schleimer RP et al. | Selective inhibition of arachidonic acid metabolite release from human lung tissue by antiinflammatory steroids. | 1986 | J. Immunol. | pmid:3082976 |
Böhm R and Giessler AJ | [Thrombocyte aggregation inhibitors. A new class of active substances]. | 1986 | Pharmazie | pmid:3515372 |
Viero P et al. | Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism? | 1986 | Haemostasis | pmid:3699584 |
Etienne A et al. | In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. | 1986 | Agents Actions | pmid:3515870 |
Nunez D et al. | Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988. | 1986 | Eur. J. Pharmacol. | pmid:3086108 |
Oxholm P and Winther K | Thrombocyte involvement in immune inflammatory reactions. | 1986 | Allergy | pmid:3515999 |
Wallace JL and Whittle BJ | Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. | 1986 | Prostaglandins | pmid:3726156 |
DeFeudis FV | Possible relationship between the syntheses of endothelium-derived relaxing factor (EDRF) and PAF-acether. | 1986 | Gen. Pharmacol. | pmid:3516791 |
Eche N et al. | Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). | 1986 | Thromb. Res. | pmid:3726808 |
Camussi G | Potential role of platelet-activating factor in renal pathophysiology. | 1986 | Kidney Int. | pmid:3517457 |
Hoffman DR et al. | The role of platelet-activating factor in human fetal lung maturation. | 1986 | Am. J. Obstet. Gynecol. | pmid:3728606 |
Mastacchi R et al. | Interaction of a new low molecular weight heparin (OP/LMWH) with human platelets. | 1986 | Agents Actions | pmid:3518359 |
Simmet T and Peskar BA | Eicosanoids and the coronary circulation. | 1986 | Rev. Physiol. Biochem. Pharmacol. | pmid:3520775 |
Conrad GW and Rink TJ | Platelet activating factor raises intracellular calcium ion concentration in macrophages. | 1986 | J. Cell Biol. | pmid:3733874 |
Moudgil GC | Anaesthesia and allergic drug reactions. | 1986 | Can Anaesth Soc J | pmid:3521800 |
Imura Y et al. | Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988. | 1986 | Life Sci. | pmid:3741541 |
Foegh ML et al. | Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet-activating factor. | 1986 | Transplantation | pmid:3523888 |
Kertscher HP and Ostermann G | [Synthesis and thrombocyte aggregating action of stereoisomers of PAF-acether]. | 1986 | Pharmazie | pmid:3786385 |
Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
Powling MJ and Hardisty RM | Differential effects of 12-O-tetradecanoylphorbol 13-acetate on platelet responses to various agonists in the presence and absence of extracellular Ca2+. | 1986 | Thromb. Res. | pmid:3787566 |
Siffert W et al. | Inhibition of platelet aggregation by amiloride. | 1986 | Thromb. Res. | pmid:3787567 |
Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
Wardlaw AJ et al. | Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. | 1986 | J. Clin. Invest. | pmid:3023451 |
Toyofuku T et al. | Effects of ONO-6240, a platelet-activating factor antagonist, on endotoxin shock in unanesthetized sheep. | 1986 | Prostaglandins | pmid:3754344 |
O'Flaherty JT | Age dependency of the inflammatory response. | 1986 | Lab. Invest. | pmid:3537520 |
Touvay C et al. | Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. | 1986 | Agents Actions | pmid:3754380 |
Sybertz EJ et al. | AGEPC, a vasodilator phospholipid with profound circulatory actions. | 1986 | Prog. Clin. Biol. Res. | pmid:3538024 |
Sugatani J and Hanahan DJ | Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. | 1986 | Arch. Biochem. Biophys. | pmid:3754710 |
McGowan HM et al. | Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. | 1986 | Am. J. Physiol. | pmid:3538908 |
Hsueh W et al. | Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. | 1986 | Eur. J. Pharmacol. | pmid:3754817 |
Hemmendinger S et al. | [Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro]. | 1986 | Ann. Biol. Clin. (Paris) | pmid:3538949 |
Okamoto M et al. | Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. | 1986 | Thromb. Res. | pmid:3754990 |
Zimmerman GA and Klein-Knoeckel D | Human endothelial cells inhibit granulocyte aggregation in vitro. | 1986 | J. Immunol. | pmid:3009611 |
Villamediana LM et al. | Effects of the platelet-activating factor antagonist BN 52021 on the hemodynamics of rats with experimental cirrhosis of the liver. | 1986 | Life Sci. | pmid:3755490 |
Garay R and Braquet P | Involvement of K+ movements in the membrane signal induced by PAF-acether. | 1986 | Biochem. Pharmacol. | pmid:3755602 |
Pfueller SL and David R | Different platelet specificities of heparin-dependent platelet aggregating factors in heparin-associated immune thrombocytopenia. | 1986 | Br. J. Haematol. | pmid:3756098 |
Hoffman DR et al. | Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells. | 1986 | Cancer Res. | pmid:3756924 |
Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
Alloatti G et al. | Effect of platelet-activating factor (PAF) on human cardiac muscle. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3941007 |
Porcellini G | [Platelet-activating factor: a new biochemical and pharmacologic frontier]. | 1986 | Clin Ter | pmid:3720244 |
Wallace JL and Whittle BJ | Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. | 1986 | Eur. J. Pharmacol. | pmid:3720841 |
Oh-ishi S et al. | Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3829203 |
Handley DA et al. | Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. | 1986 | Immunopharmacology | pmid:3733419 |
Flower RJ | Background and discovery of lipocortins. | 1986 | Agents Actions | pmid:2938452 |
Ramesha CS and Pickett WC | Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. | 1986 | Biomed. Environ. Mass Spectrom. | pmid:2938649 |
Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
Gay JC et al. | Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor. | 1986 | Blood | pmid:3006836 |
Stimler-Gerard NP | Parasympathetic stimulation as a mechanism for platelet-activating factor-induced contractile responses in the lung. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3958964 |
Wade PJ et al. | Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets. | 1986 | Thromb. Res. | pmid:3961730 |
Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
Okayasu T et al. | Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. | 1986 | Biochim. Biophys. Acta | pmid:3947669 |
Tarayre JP et al. | Inflammatory action of PAF-acether in the rat pleural cavity. | 1986 | Agents Actions | pmid:3962789 |
Blank ML et al. | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells. | 1986 | Biochim. Biophys. Acta | pmid:3707974 |
Baranes J et al. | The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021. | 1986 | Pharmacol Res Commun | pmid:3763677 |
Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
Kikawa Y et al. | Leukotriene B4 biosynthesis in polymorphonuclear leukocytes from blood of umbilical cord, infants, children, and adults. | 1986 | Pediatr. Res. | pmid:3012451 |
Burhop KE et al. | Platelet-activating factor increases lung vascular permeability to protein. | 1986 | J. Appl. Physiol. | pmid:3804927 |
Bussolino F et al. | Production of platelet-activating factor by chick retina. | 1986 | J. Biol. Chem. | pmid:3023352 |
Cox CP | Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets. | 1986 | Thromb. Res. | pmid:2421432 |
Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives. | 1986 | Chem. Pharm. Bull. | pmid:2421923 |
Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models. | 1986 | Chem. Pharm. Bull. | pmid:2421924 |
Robertson DN and Smith GM | CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen. | 1986 | Eur. J. Pharmacol. | pmid:3709663 |
Darius H et al. | Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. | 1986 | Science | pmid:3082008 |
Kohayakawa M and Inoue K | Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. | 1986 | Thromb. Res. | pmid:3083530 |
Morley J et al. | Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. | 1986 | Ann Allergy | pmid:3083731 |
McIntosh TK and Faden AI | Thyrotropin-releasing hormone (TRH) and circulatory shock. | 1986 | Circ. Shock | pmid:3084122 |
Bussolino F et al. | Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells. | 1986 | Pharmacol Res Commun | pmid:3490673 |
Hackenthal E and Taugner R | Hormonal signals and intracellular messengers for renin secretion. | 1986 | Mol. Cell. Endocrinol. | pmid:2875004 |
Swingle KF and Reiter MJ | Inhibition of Paf-acether-induced edema of the rat's paw. | 1986 | Agents Actions | pmid:2875631 |
Ghezzi E | Autacoids and some mediators in allergic and non allergic forms. | 1986 | Boll Ist Sieroter Milan | pmid:2877678 |
Pécoud A and Frei PC | [Developmental trends in allergologic-immunologic research]. | 1986 | Internist (Berl) | pmid:2427469 |
Raphael GD and Metcalfe DD | Mediators of airway inflammation. | 1986 | Eur J Respir Dis Suppl | pmid:2429857 |
Yoshida J et al. | A platelet-aggregating and hypotensive phospholipid isolated from bovine brain. | 1986 | J. Pharm. Pharmacol. | pmid:2880959 |
Mossmann H et al. | Effect of platelet-activating factor on human polymorphonuclear leukocyte enhancement of chemiluminescence and antibody-dependent cellular cytotoxicity. | 1986 | J. Leukoc. Biol. | pmid:3455715 |
Mehta J et al. | Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. | 1986 | Prostaglandins Leukot Med | pmid:3456620 |
McIntyre TM et al. | Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3457383 |
Di Marzo V et al. | The effect of vasoactive intestinal peptide and calcitonin gene-related peptide on peptidoleukotriene release from platelet activating factor stimulated rat lungs and ionophore stimulated guinea pig lungs. | 1986 | Biochem. Int. | pmid:2432897 |
Oh S et al. | Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. | 1986 | Prostaglandins Leukot Med | pmid:3459197 |
Ramesha CS and Pickett WC | Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes. | 1986 | J. Biol. Chem. | pmid:3096991 |
Newhouse MT and Sears MR | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3462569 |
Chignard M et al. | Direct evidence for the existence of a neutrophil-derived platelet activator (neutrophilin). | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3464972 |
Hahn HL et al. | Effects of platelet activating factor on tracheal mucus secretion, on airway mechanics and on circulating blood cells in live ferrets. | 1986 | Eur J Respir Dis Suppl | pmid:3465554 |
Morley J and Sanjar S | Ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466080 |
Page CP | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466093 |
Kloprogge E and Akkerman JW | Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. | 1986 | Biochem. J. | pmid:3101672 |
PAF and leukotrienes '85. Proceedings of the meeting. Paris, September 27th 1985. | 1986 | Pharmacol Res Commun | pmid:3774839 | |
Vilain B et al. | Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. | 1986 | Pharmacol Res Commun | pmid:3774840 |
Etienne A et al. | Antithrombotic activity of BN 50341, a structurally new compound with anticalcic and PAF-antagonistic properties. | 1986 | Agents Actions Suppl. | pmid:3468781 |
Bessin P | PAF-acether and leukotriene participation in acute circulatory shock. | 1986 | Pharmacol Res Commun | pmid:3774841 |
Goldstein RE et al. | Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774842 |
Plante GE et al. | Hemodynamic effects of PAF-acether. | 1986 | Pharmacol Res Commun | pmid:3774843 |
Sanchez Crespo M et al. | Evidence of a role for PAF-acether in the pathophysiology of the shock state. | 1986 | Pharmacol Res Commun | pmid:3774844 |
Adnot S et al. | Interference of BN 52021, a PAF-acether antagonist, with endotoxin-induced hypotension in the guinea-pig. | 1986 | Pharmacol Res Commun | pmid:3774845 |
Rainsford KD | Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. | 1986 | Pharmacol Res Commun | pmid:3774846 |
Page CP and Morley J | Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma. | 1986 | Pharmacol Res Commun | pmid:3774847 |
Haye-Legrand I et al. | Production of PAF-acether and leukotrienes by cultured mouse macrophages. | 1986 | Pharmacol Res Commun | pmid:3774848 |
Lee TC et al. | A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. | 1986 | J. Biol. Chem. | pmid:3007498 |