| MeSH term | MeSH ID | Detail |
|---|---|---|
| Spasm | D013035 | 5 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Colonic Diseases | D003108 | 5 associated lipids |
| Shock, Cardiogenic | D012770 | 5 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Gliosis | D005911 | 6 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Glomerulonephritis, Membranous | D015433 | 6 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Coronary Stenosis | D023921 | 6 associated lipids |
| Xeroderma Pigmentosum | D014983 | 6 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Blood Loss, Surgical | D016063 | 6 associated lipids |
| Purpura, Thrombotic Thrombocytopenic | D011697 | 6 associated lipids |
| Mucositis | D052016 | 7 associated lipids |
| Bronchiectasis | D001987 | 7 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Rheumatic Diseases | D012216 | 7 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Archer SL and Roudebush WE | Enhancement of sperm motility using pentoxifylline and platelet-activating factor. | 2013 | Methods Mol. Biol. | pmid:22992918 |
| Watschinger K and Werner ER | Orphan enzymes in ether lipid metabolism. | 2013 | Biochimie | pmid:22771767 |
| Flasiński M et al. | Interactions between single-chained ether phospholipids and sphingomyelin in mixed monolayers at the air/water interface-Grazing incidence X-ray diffraction and Brewster angle microscopy studies. | 2013 | Colloids Surf B Biointerfaces | pmid:23777791 |
| Grotta MB et al. | Obesity increases eosinophil activity in asthmatic children and adolescents. | 2013 | BMC Pulm Med | pmid:23773659 |
| Zhou Z et al. | Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity. | 2013 | Fitoterapia | pmid:23669034 |
| Wang TM et al. | Alkyl and phenolic glycosides from Saussurea stella. | 2013 | Fitoterapia | pmid:23567860 |
| Schäfer-Somi S et al. | Vascular endothelial (VEGF) and epithelial growth factor (EGF) as well as platelet-activating factor (PAF) and receptors are expressed in the early pregnant canine uterus. | 2013 | Reprod. Domest. Anim. | pmid:22458960 |
| Herndon B et al. | Urease and Helicobacter spp. antigens in pulmonary granuloma. | 2013 | J. Comp. Pathol. | pmid:22901429 |
| Nasopoulou C et al. | Hen egg yolk lipid fractions with antiatherogenic properties. | 2013 | Anim. Sci. J. | pmid:23480708 |
| Sato A et al. | An endothelin-3-related synthetic biotinylated pentapeptide as a novel inhibitor of platelet-activating factor. | 2013 | Eur. J. Pharmacol. | pmid:23792041 |
| Ayaz G et al. | The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population. | 2013 | Gene | pmid:23816407 |
| Yamazaki Y et al. | A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. | 2013 | Biochem. Pharmacol. | pmid:23817078 |
| Xia SH et al. | Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. | 2013 | World J. Gastroenterol. | pmid:23840141 |
| Mazereeuw G et al. | Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. | 2013 | Neurosci Biobehav Rev | pmid:23800745 |
| Wang C et al. | Anti-platelet-activating factor, antibacterial, and antiradical activities of lipids extract from silver carp brain. | 2013 | Lipids Health Dis | pmid:23805935 |
| Nettis E et al. | Rupatadine for the treatment of urticaria. | 2013 | Expert Opin Pharmacother | pmid:23806068 |
| Sato A and Ebina K | [Interaction between Asp-hemolysin-related synthetic peptides and oxidized LDL/lysophospholipids]. | 2013 | Seikagaku | pmid:23819394 |
| Compalati E and Canonica GW | Efficacy and safety of rupatadine for allergic rhino-conjunctivitis: a systematic review of randomized, double-blind, placebo-controlled studies with meta-analysis. | 2013 | Curr Med Res Opin | pmid:23826741 |
| Xu H et al. | Targeted lipidomics - advances in profiling lysophosphocholine and platelet-activating factor second messengers. | 2013 | FEBS J. | pmid:23826908 |
| Liu G et al. | Characterization of streptococcal platelet-activating factor acetylhydrolase variants that are involved in innate immune evasion. | 2013 | Infect. Immun. | pmid:23774595 |
| Tokuoka SM et al. | Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23743196 |
| Stanca E et al. | Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin. | 2013 | Biochim. Biophys. Acta | pmid:23851051 |
| Nagase T | [Respiratory failure]. | 2013 | Nippon Rinsho | pmid:23855209 |
| Vlachogianni IC et al. | Interleukin-1beta stimulates platelet-activating factor production in U-937 cells modulating both its biosynthetic and catabolic enzymes. | 2013 | Cytokine | pmid:23673285 |
| Hirayama F | Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. | 2013 | Br. J. Haematol. | pmid:23215650 |
| Harleton E et al. | Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). | 2013 | J. Biol. Chem. | pmid:23229553 |
| Detopoulou P et al. | Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. | 2013 | Curr Heart Fail Rep | pmid:23389700 |
| Wang HL et al. | Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. | 2013 | Chin J Physiol | pmid:23347011 |
| Motoyama N et al. | Pain-releasing action of platelet-activating factor (PAF) antagonists in neuropathic pain animal models and the mechanisms of action. | 2013 | Eur J Pain | pmid:23355413 |
| Tsoupras AB et al. | Synthesis, biochemical evaluation and molecular modeling studies of novel rhodium complexes with nanomolar activity against Platelet Activating Factor. | 2013 | J. Inorg. Biochem. | pmid:23318288 |
| Krause K et al. | Platelet-activating factor (PAF) induces wheal and flare skin reactions independent of mast cell degranulation. | 2013 | Allergy | pmid:23320562 |
| Vanstreels L and Merk HF | [Value of in-vitro diagnostic tools after anaphylaxis]. | 2013 | Hautarzt | pmid:23385619 |
| Sato A and Ebina K | Endothelin-3 at low concentrations attenuates inflammatory responses via the endothelin B2 receptor. | 2013 | Inflamm. Res. | pmid:23370722 |
| Singh P et al. | Platelet-activating factor (PAF)-antagonists of natural origin. | 2013 | Fitoterapia | pmid:23160091 |
| Costa M et al. | Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. | 2013 | Stem Cell Res | pmid:23164599 |
| Sirangelo I et al. | Amyloid toxicity and platelet-activating factor signaling. | 2013 | J. Cell. Physiol. | pmid:23169529 |
| Murakami M and Lambeau G | Emerging roles of secreted phospholipase A(2) enzymes: an update. | 2013 | Biochimie | pmid:23022039 |
| Vadas P et al. | Platelet-activating factor, histamine, and tryptase levels in human anaphylaxis. | 2013 | J. Allergy Clin. Immunol. | pmid:23040367 |
| Kawano DF and Carvalho I | Targeting Trypanosoma cruzi platelet-activating factor receptors: scope for the development of novel drugs to treat Chagas Disease. | 2013 | Mini Rev Med Chem | pmid:23544467 |
| Wei JF et al. | Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. | 2013 | Biomed Res Int | pmid:23509689 |
| Forsman H et al. | Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. | 2013 | PLoS ONE | pmid:23555913 |
| Nankar SA et al. | Differential interaction of peptides derived from C-terminal domain of human apolipoprotein E with platelet activating factor analogs. | 2013 | Biochimie | pmid:23376877 |
| Detopoulou P et al. | Baseline and 6-Week follow-up levels of PAF and activity of its metabolic enzymes in patients with heart failure and healthy volunteers--a pilot study. | 2013 | Angiology | pmid:23000600 |
| Xu B et al. | Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. | 2013 | Br. J. Cancer | pmid:23949154 |
| Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
| Cui H et al. | Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. | 2013 | J. Allergy Clin. Immunol. | pmid:24021572 |
| Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
| Lv XX et al. | Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. | 2013 | PLoS ONE | pmid:23869224 |
| Maziero AM et al. | Inhibition of human platelet aggregation by eosinophils. | 2013 | Life Sci. | pmid:23871985 |
| Borthakur A et al. | Lactobacillus acidophilus alleviates platelet-activating factor-induced inflammatory responses in human intestinal epithelial cells. | 2013 | PLoS ONE | pmid:24130731 |
| Predescu S et al. | Platelet activating factor-induced ceramide micro-domains drive endothelial NOS activation and contribute to barrier dysfunction. | 2013 | PLoS ONE | pmid:24086643 |
| Sahu RP et al. | Cigarette smoke exposure inhibits contact hypersensitivity via the generation of platelet-activating factor agonists. | 2013 | J. Immunol. | pmid:23355733 |
| Berman B and Cockerell CJ | Pathobiology of actinic keratosis: ultraviolet-dependent keratinocyte proliferation. | 2013 | J. Am. Acad. Dermatol. | pmid:23228301 |
| Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
| Renteria LS et al. | RhoA-Rho kinase and platelet-activating factor stimulation of ovine foetal pulmonary vascular smooth muscle cell proliferation. | 2013 | Cell Prolif. | pmid:24033386 |
| Verouti SN et al. | Paricalcitol effects on activities and metabolism of platelet activating factor and on inflammatory cytokines in hemodialysis patients. | 2013 | Int J Artif Organs | pmid:23335378 |
| Zhao C et al. | Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. | 2013 | PLoS ONE | pmid:24367540 |
| Barbier M et al. | Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia. | 2013 | MBio | pmid:23653444 |
| Fontbonne H et al. | Activation of bile salt dependent lipase by (lyso)phosphatidic acid and platelet activating factor. | 2013 | FEBS Lett. | pmid:23891620 |
| Feuerherm AJ et al. | Platelet-activating factor induces proliferation in differentiated keratinocytes. | 2013 | Mol. Cell. Biochem. | pmid:23975504 |
| Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
| Shi YM et al. | Lancolides, antiplatelet aggregation nortriterpenoids with tricyclo[6.3.0.0(2,11)]undecane-bridged system from Schisandra lancifolia. | 2013 | Org. Lett. | pmid:24059675 |
| Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |
| Muñoz-Cano R et al. | Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. | 2013 Mar-Apr | Am J Rhinol Allergy | pmid:23562190 |
| Frazer CA | Heparin-induced thrombocytopenia. | 2013 Nov-Dec | Medsurg Nurs | pmid:24600938 |
| Yamauchi A et al. | Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. | 2014 | J. Immunol. Methods | pmid:24370750 |
| Sahu RP et al. | Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. | 2014 | Cancer Res. | pmid:25304264 |
| Yu Y et al. | Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. | 2014 | J. Exp. Clin. Cancer Res. | pmid:25261977 |
| Agrawal V et al. | Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. | 2014 | Biol. Reprod. | pmid:25253732 |
| Wang M et al. | Mouse anaphylactic shock is caused by reduced cardiac output, but not by systemic vasodilatation or pulmonary vasoconstriction, via PAF and histamine. | 2014 | Life Sci. | pmid:25252221 |
| Liu X et al. | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. | 2014 | Thromb. Res. | pmid:25223809 |
| Kang LP et al. | Steroidal saponins from Tribulus terrestris. | 2014 | Phytochemistry | pmid:25172515 |
| Wu KZ et al. | Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill. | 2014 | Interdiscip Sci | pmid:25172450 |
| Nitoda E et al. | Correlation of platelet activating factor and age-related macular degeneration. | 2014 | Expert Opin. Ther. Targets | pmid:25077601 |
| Sirangelo I et al. | Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells. | 2014 | J. Cell. Biochem. | pmid:25053109 |
| Xanthopoulou MN et al. | Effect of Robola and Cabernet Sauvignon extracts on platelet activating factor enzymes activity on U937 cells. | 2014 | Food Chem | pmid:25038648 |
| Concha C et al. | Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. | 2014 | J. Vet. Sci. | pmid:25013355 |
| Mazereeuw G et al. | Platelet-activating factors are associated with cognitive deficits in depressed coronary artery disease patients: a hypothesis-generating study. | 2014 | J Neuroinflammation | pmid:24996486 |
| Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
| Triggiani M et al. | Anaphylaxis and cardiovascular diseases: a dangerous liaison. | 2014 | Curr Opin Allergy Clin Immunol | pmid:24915548 |
| Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
| Papakonstantinou VD et al. | In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients. | 2014 | Lipids Health Dis | pmid:24884881 |
| Marathe GK et al. | To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase. | 2014 | J. Lipid Res. | pmid:24859738 |
| Zanatta AL et al. | Fish oil supplementation decreases oxidative stress but does not affect platelet-activating factor bioactivity in lungs of asthmatic rats. | 2014 | Lipids | pmid:24858941 |
| Mitchell MJ et al. | Fluid shear stress increases neutrophil activation via platelet-activating factor. | 2014 | Biophys. J. | pmid:24853753 |
| Mallet de Lima CD et al. | Central role of PAFR signalling in ExoU-induced NF-κB activation. | 2014 | Cell. Microbiol. | pmid:24612488 |
| Moschos MM et al. | In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. | 2014 | Cutan Ocul Toxicol | pmid:24147947 |
| Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
| Chacón-Salinas R et al. | An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. | 2014 | J. Leukoc. Biol. | pmid:24009177 |
| Mehta A and Sigman M | Identification and preparation of sperm for ART. | 2014 | Urol. Clin. North Am. | pmid:24286775 |
| Reyes-Quiroz ME et al. | Platelet-activating factor downregulates the expression of liver X receptor-α and its target genes in human neutrophils. | 2014 | FEBS J. | pmid:24289152 |
| Semini G et al. | Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation. | 2014 | Biochem. Pharmacol. | pmid:24291779 |
| Sugatani J et al. | Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. | 2014 | FASEB J. | pmid:24100020 |
| Fang W et al. | Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain. | 2014 | J. Neurochem. | pmid:24164378 |
| Gazos-Lopes F et al. | Structural and functional analysis of a platelet-activating lysophosphatidylcholine of Trypanosoma cruzi. | 2014 | PLoS Negl Trop Dis | pmid:25101628 |
| Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
| Morimoto R et al. | Rapid production of platelet-activating factor is induced by protein kinase Cα-mediated phosphorylation of lysophosphatidylcholine acyltransferase 2 protein. | 2014 | J. Biol. Chem. | pmid:24742674 |
| Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
| Yang Y et al. | Basophil activation through ASGM1 stimulation triggers PAF release and anaphylaxis-like shock in mice. | 2014 | Eur. J. Immunol. | pmid:24777913 |
| Tarui M et al. | Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. | 2014 | J. Lipid Res. | pmid:24850807 |