Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Coronary Thrombosis D003328 7 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Death, Sudden D003645 12 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Dictyocaulus Infections D004022 1 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Dyslexia D004410 3 associated lipids
Ear Diseases D004427 7 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Kawasaki T and Snyder F Synthesis of a novel acetylated neutral lipid related to platelet-activating factor by acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol acyltransferase in HL-60 cells. 1988 J. Biol. Chem. pmid:3422635
Hoffman DR et al. Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. 1988 Lipids pmid:2897059
Leff AR Neurohumoral regulation of airway contractile responses. 1988 Chest pmid:2897271
Junier MP et al. Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. 1988 Endocrinology pmid:2898362
Guinot P et al. Treatment of adult systemic mastocytosis with a PAF-acether antagonist BN52063. 1988 Lancet pmid:2898694
Michel L et al. Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. 1988 J. Allergy Clin. Immunol. pmid:2899102
Bourdillat B et al. Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. 1988 Eur. J. Pharmacol. pmid:2836213
Toyofuku T et al. Pulmonary vascular response to platelet-activating factor in conscious sheep. 1988 Am. J. Physiol. pmid:3414811
Altin JG and Bygrave FL Prostaglandin F2 alpha and the thromboxane A2 analogue ONO-11113 stimulate Ca2+ fluxes and other physiological responses in rat liver. Further evidence that prostanoids may be involved in the action of arachidonic acid and platelet-activating factor. 1988 Biochem. J. pmid:3128268
Yamada K et al. Parallel inhibition of platelet-activating factor-induced protein phosphorylation and serotonin release by K-252a, a new inhibitor of protein kinases, in rabbit platelets. 1988 Biochem. Pharmacol. pmid:3128296
Martins MA et al. Intravenous injections of PAF-acether induce platelet aggregation in rats. 1988 Eur. J. Pharmacol. pmid:3135199
Peers SH Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. 1988 Eur. J. Pharmacol. pmid:3136026
Fernandez-Gallardo S et al. Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. 1988 Biochem. J. pmid:2848496
Mangold HK Synthesis of biologically active ether lipids. 1988 Prog Biochem Pharmacol pmid:3136454
Anderson GP et al. Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites. 1988 Agents Actions pmid:3136622
Fernandez-Gallardo S et al. Role of paf-acether in the mediation of pathophysiological responses to aggregated immunoglobulins. Studies with the platelet-activating factor receptor antagonist BN 52021. 1988 Int. J. Immunopharmacol. pmid:3139574
Slapke J et al. [Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension]. 1988 Prax Klin Pneumol pmid:3140230
Neuwirth R et al. Evidence for immunoglobulin Fc receptor-mediated prostaglandin2 and platelet-activating factor formation by cultured rat mesangial cells. 1988 J. Clin. Invest. pmid:3166467
Rossi AG et al. Stereospecific bioactions of 5-hydroxyeicosatetraenoate. 1988 FEBS Lett. pmid:3191990
Nakamura T et al. Effect of azelastine on the intracellular Ca2+ mobilization in guinea pig peritoneal macrophages. 1988 Eur. J. Pharmacol. pmid:2898372
Berti F et al. New pharmacological data on the bronchospasmolytic activity of bamifylline. 1988 Arzneimittelforschung pmid:3365275
Sun XM and Hsueh W Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. 1988 J. Clin. Invest. pmid:3366898
Calignano A et al. Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin. 1988 J Pharmacol Methods pmid:3367652
Nolte D [Bronchial hyperreactivity: pingpong between cells, nerves and mediators]. 1988 Med. Klin. (Munich) pmid:3367876
Bratton DL et al. Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine. 1988 Biochim. Biophys. Acta pmid:3370214
Myers AK et al. Antagonism of PAF-induced death in mice. 1988 Prostaglandins pmid:3131837
Handley DA et al. Biological effects of the orally active platelet activating factor receptor antagonist SDZ 64-412. 1988 J. Pharmacol. Exp. Ther. pmid:3183958
Jouquey S et al. Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. 1988 Agents Actions pmid:2459935
Spinks NR and O'Neill C Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos. 1988 J. Reprod. Fertil. pmid:2460623
Dorsch W et al. Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo. 1988 Biochem. Pharmacol. pmid:2462422
Evans TW et al. Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man. 1988 Br. J. Pharmacol. pmid:3401633
Lagente V et al. Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig. 1988 Br. J. Pharmacol. pmid:3401641
Groscurth P et al. Effects of platelet activating factor (PAF) on human citrated whole blood. 1988 Eur. J. Haematol. pmid:3402585
Rylander R et al. Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). 1988 Int. Arch. Allergy Appl. Immunol. pmid:3403044
Satoh K et al. [Endothelial injury as an initiating factor: vascular endothelial cell injury and biosynthesis of PAF]. 1988 Nippon Rinsho pmid:3404682
Nogami M et al. [Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress]. 1988 Nihon Shokakibyo Gakkai Zasshi pmid:3404759
Kumar R et al. Production and effects of platelet-activating factor in the rat brain. 1988 Biochim. Biophys. Acta pmid:3196741
Bette-Bobillo P and Bienvenue A Platelet-activating-factor-induced serum-albumin release from rabbit platelets in the absence of calcium. 1988 Eur. J. Biochem. pmid:3197724
Cueva JP and Hsueh W Role of oxygen derived free radicals in platelet activating factor induced bowel necrosis. 1988 Gut pmid:3197995
Bass DA et al. Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. 1988 J. Biol. Chem. pmid:3198643
Lewis MS et al. Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. 1988 J. Clin. Invest. pmid:3198764
Misawa M and Takata T Effects of platelet-activating factor on rat airways. 1988 Jpn. J. Pharmacol. pmid:3199608
Kato T et al. Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). 1988 Biochem. Biophys. Res. Commun. pmid:3202869
Willuweit B and Aktories K Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. 1988 Naunyn Schmiedebergs Arch. Pharmacol. pmid:2969081
Jancar S et al. Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. 1988 Prostaglandins pmid:2969600
Tkhostov EB et al. [Calcium metabolism in arterial hypertension. I. Myocardial hypertrophy and hormone-dependent increase in Ca2+ levels in the thrombocytes of patients with arterial hypertension]. 1988 Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR pmid:2969736
Leprevost C et al. Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). 1988 Int. Arch. Allergy Appl. Immunol. pmid:2971624
Ohmori K et al. Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. 1988 Arzneimittelforschung pmid:2972291
Valone FH et al. Enhanced human monocyte cytotoxicity by platelet-activating factor. 1988 Immunology pmid:3169845
Popovich KJ et al. Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro. 1988 J. Appl. Physiol. pmid:3170437
Moriyama T et al. Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. 1988 J. Biochem. pmid:3170519
Lagente V et al. PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists. 1988 J. Pharmacol. Exp. Ther. pmid:3171975
Danko G et al. Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis. 1988 Pharmacol Res Commun pmid:3174804
Bussolino F et al. Platelet activating factor induces dopamine release in PC-12 cell line. 1988 Am. J. Physiol. pmid:3177629
Imai T et al. Pulmonary hypertension and edema induced by platelet-activating factor in isolated, perfused rat lungs are blocked by BN52021. 1988 J. Lab. Clin. Med. pmid:3339274
Wichrowski B et al. Structure-activity relationship in PAF-acether. 4. Synthesis and biological activities of carboxylate isosteres. 1988 J. Med. Chem. pmid:3339611
Tilley JW et al. Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. 1988 J. Med. Chem. pmid:3339617
Ferguson MK et al. Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. 1988 J. Surg. Res. pmid:3339877
Kelefiotis D et al. Study of digoxin as inhibitor of the in vivo effects of acetyl glyceryl ether phosphorylcholine (AGEPC) in mice. 1988 Life Sci. pmid:3339951
Soybel DI et al. Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. 1988 Am. J. Surg. pmid:3341532
Kumar R et al. Occurrence of platelet-activating factor in rabbit spermatozoa. 1988 Arch. Biochem. Biophys. pmid:3341753
Page CP and Robertson DN The role of PAF in altered airway responsiveness. 1988 Prog. Clin. Biol. Res. pmid:3289016
Arnout J et al. Effectiveness and tolerability of CV-3988, a selective PAF antagonist, after intravenous administration to man. 1988 Br J Clin Pharmacol pmid:3289599
O'Donnell SR and Barnett CJ pA2 values for antagonists of platelet activating factor on aggregation of rabbit platelets. 1988 Br. J. Pharmacol. pmid:3293683
Giovannini L et al. N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney. 1988 Int J Tissue React pmid:3294206
Nakayama R et al. 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. 1988 Biochem. Biophys. Res. Commun. pmid:3355555
Kramer RM et al. Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2. 1988 Biochim. Biophys. Acta pmid:3355850
McGowan HM et al. Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat. 1988 Clin. Sci. pmid:3356112
Quinn MT et al. Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. 1988 Proc. Natl. Acad. Sci. U.S.A. pmid:3357891
Brass LF et al. Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase. 1988 J. Biol. Chem. pmid:2833506
Blank ML et al. Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. 1988 J. Biol. Chem. pmid:2833508
Tatsumi N et al. Neutrophil chemiluminescence induced by platelet activating factor and suppressed by C-reactive protein. 1988 Clin. Chim. Acta pmid:3359655
Rola-Pleszczynski M et al. Immune regulation by platelet-activating factor. I. Induction of suppressor cell activity in human monocytes and CD8+ T cells and of helper cell activity in CD4+ T cells. 1988 J. Immunol. pmid:2834440
Worthen GS et al. The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion. 1988 J. Immunol. pmid:2834441
Hwang SB et al. Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor. 1988 J. Pharmacol. Exp. Ther. pmid:2841449
Parnham MJ PAF receptors. 1988 Prog Biochem Pharmacol pmid:2841664
Shkhvatsabaia IK et al. [Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients]. 1988 Kardiologiia pmid:2842537
Tahraoui L et al. High affinity specific binding sites for tritiated platelet-activating factor in canine platelet membranes: counterparts of platelet-activating factor receptors mediating platelet aggregation. 1988 Mol. Pharmacol. pmid:2842653
Heuer H and Casals-Stenzel J Effect of the PAF-antagonist WEB 2086 on anaphylactic lung reaction: comparison of inhalative and intravenous challenge. 1988 Agents Actions Suppl. pmid:3262991
Garcia JG et al. Effect of platelet activating factor on leukocyte-endothelial cell interactions. 1988 Thromb. Res. pmid:2842887
Ontell SJ et al. Improved hepatic function in the 24-hour preserved rat liver with UW-lactobionate solution and SRI 63-441. 1988 Gastroenterology pmid:3263295
Ng DS and Wong K Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. 1988 Biochem. Biophys. Res. Commun. pmid:2843182
Breviario F et al. IL-1-induced adhesion of polymorphonuclear leukocytes to cultured human endothelial cells. Role of platelet-activating factor. 1988 J. Immunol. pmid:3263425
Page CP The role of platelet-activating factor in asthma. 1988 J. Allergy Clin. Immunol. pmid:3276759
Barnes PJ Platelet-activating factor and asthma. 1988 J. Allergy Clin. Immunol. pmid:3276760
Miller MJ et al. SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. 1988 Am. J. Physiol. pmid:2847541
Bussolino F et al. Acetylcholine and dopamine promote the production of platelet activating factor in immature cells of chick embryonic retina. 1988 J. Neurochem. pmid:2846783
Birkle DL et al. Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock. 1988 J. Neurochem. pmid:2846788
Rouis M et al. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. 1988 Biochem. Biophys. Res. Commun. pmid:2847729
Doni MG et al. Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. 1988 Biochem. Biophys. Res. Commun. pmid:2847730
Fradin A et al. Inhibition of eicosanoid and PAF formation by dexamethasone in rat inflammatory polymorphonuclear neutrophils may implicate lipocortin 's'. 1988 Biochim. Biophys. Acta pmid:2848583
Ghigo D et al. Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells. 1988 J. Biol. Chem. pmid:2848827
Perico N et al. Effect of platelet-activating factor and its specific receptor antagonist on glomerular permeability to proteins in isolated perfused rat kidney. 1988 Lab. Invest. pmid:3123798
Aratani H et al. Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes. 1988 Jpn. J. Pharmacol. pmid:2848961
Fisher RA et al. AGEPC: a potent calcium-dependent chemical mediator in the liver. 1988 Adv. Exp. Med. Biol. pmid:3213685
Mickelson JK et al. Myocardial dysfunction and coronary vasoconstriction induced by platelet-activating factor in the post-infarcted rabbit isolated heart. 1988 J. Mol. Cell. Cardiol. pmid:3216407
Bussolino F [Production of PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in the chick retina during embryogenesis]. 1988 Ann. Ist. Super. Sanita pmid:3218801
Dillon PK et al. Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Time course and dose-response relationships. 1988 Inflammation pmid:3220518
Lohmann HF et al. Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. 1988 Lancet pmid:2903365
White HL and Faison LD Inhibition of lyso-PAF: acetyl-CoA acetyltransferase by salicylates and other compounds. 1988 Prostaglandins pmid:2903520