| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Thrombosis | D003328 | 7 associated lipids |
| Cystic Fibrosis | D003550 | 65 associated lipids |
| Cystitis | D003556 | 23 associated lipids |
| Death, Sudden | D003645 | 12 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Dictyocaulus Infections | D004022 | 1 associated lipids |
| Disseminated Intravascular Coagulation | D004211 | 7 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Duodenal Ulcer | D004381 | 12 associated lipids |
| Dyslexia | D004410 | 3 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Arnoux B et al. | Effect of PAF-acether in non-human primates. | 1988 | Prog. Clin. Biol. Res. | pmid:2837781 |
| Livio M et al. | Role of platelet-activating factor in primary hemostasis. | 1988 | Am. J. Physiol. | pmid:2837916 |
| Hoffman DR et al. | Synthesis of platelet activating factor by cholinephosphotransferase in developing fetal rabbit lung. | 1988 | Lipids | pmid:2897059 |
| Leff AR | Neurohumoral regulation of airway contractile responses. | 1988 | Chest | pmid:2897271 |
| Junier MP et al. | Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. | 1988 | Endocrinology | pmid:2898362 |
| Guinot P et al. | Treatment of adult systemic mastocytosis with a PAF-acether antagonist BN52063. | 1988 | Lancet | pmid:2898694 |
| Michel L et al. | Inhibitory effect of oral cetirizine on in vivo antigen-induced histamine and PAF-acether release and eosinophil recruitment in human skin. | 1988 | J. Allergy Clin. Immunol. | pmid:2899102 |
| Michel L et al. | Release of PAF-acether and precursors during allergic cutaneous reactions. | 1988 | Lancet | pmid:2899817 |
| Bachelet M et al. | Interaction between PAF-acether and drugs that stimulate cyclic AMP in guinea-pig alveolar macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2840303 |
| Martins MA et al. | Intravenous injections of PAF-acether induce platelet aggregation in rats. | 1988 | Eur. J. Pharmacol. | pmid:3135199 |
| Peers SH | Dexamethasone inhibits platelet activating factor-induced inflammation in the paw but not the pleural cavity of rats. | 1988 | Eur. J. Pharmacol. | pmid:3136026 |
| Mangold HK | Synthesis of biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3136454 |
| Anderson GP et al. | Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites. | 1988 | Agents Actions | pmid:3136622 |
| Fernandez-Gallardo S et al. | Role of paf-acether in the mediation of pathophysiological responses to aggregated immunoglobulins. Studies with the platelet-activating factor receptor antagonist BN 52021. | 1988 | Int. J. Immunopharmacol. | pmid:3139574 |
| Slapke J et al. | [Test hierarchy for the development of new drug action principles with the action site in phospholipid metabolism for bronchial asthma and pulmonary hypertension]. | 1988 | Prax Klin Pneumol | pmid:3140230 |
| Ferrell JE et al. | Membrane bilayer balance and platelet shape: morphological and biochemical responses to amphipathic compounds. | 1988 | Biochim. Biophys. Acta | pmid:3355815 |
| López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
| Sun XM and Hsueh W | Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. | 1988 | J. Clin. Invest. | pmid:3366898 |
| Calignano A et al. | Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin. | 1988 | J Pharmacol Methods | pmid:3367652 |
| Nolte D | [Bronchial hyperreactivity: pingpong between cells, nerves and mediators]. | 1988 | Med. Klin. (Munich) | pmid:3367876 |
| Bratton DL et al. | Effects of platelet activating factor and related lipids on phase transition of dipalmitoylphosphatidylcholine. | 1988 | Biochim. Biophys. Acta | pmid:3370214 |
| Wang J et al. | The effects of endotoxin on platelet-activating factor synthesis in cultured rat glomerular mesangial cells. | 1988 | Biochim. Biophys. Acta | pmid:3370222 |
| Smith RJ et al. | Diacylglycerols modulate human polymorphonuclear neutrophil responsiveness: effects on intracellular calcium mobilization, granule exocytosis, and superoxide anion production. | 1988 | J. Leukoc. Biol. | pmid:2836539 |
| Jouquey S et al. | Comparison of the effects of the ace inhibitors trandolapril and enalapril on phlogogen induced foot pad oedema in the rat. | 1988 | Agents Actions | pmid:2459935 |
| Spinks NR and O'Neill C | Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos. | 1988 | J. Reprod. Fertil. | pmid:2460623 |
| Dorsch W et al. | Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo. | 1988 | Biochem. Pharmacol. | pmid:2462422 |
| Serio R and Daniel EE | Thromboxane effects on canine trachealis neuromuscular function. | 1988 | J. Appl. Physiol. | pmid:2839451 |
| Lagente V and Fortes ZB | Role of PAF-acether in the vascular events of inflammation. | 1988 | Prog Biochem Pharmacol | pmid:3043429 |
| Cordeiro RS et al. | Proinflammatory activity of platelet-activating factor: pharmacological modulation and cellular involvement. | 1988 | Prog Biochem Pharmacol | pmid:3043430 |
| Pirotzky E and Braquet P | PAF-acether and kidney pathology. | 1988 | Prog Biochem Pharmacol | pmid:3043431 |
| Feuerstein G and Siren AL | Platelet-activating factor and shock. | 1988 | Prog Biochem Pharmacol | pmid:3043432 |
| Godfroid JJ and Heymans F | Chemistry of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043433 |
| Casals-Stenzel J and Heuer H | Pharmacology of PAF antagonists. | 1988 | Prog Biochem Pharmacol | pmid:3043436 |
| Evans TW et al. | Effect of a Paf antagonist, WEB 2086, on airway microvascular leakage in the guinea-pig and platelet aggregation in man. | 1988 | Br. J. Pharmacol. | pmid:3401633 |
| Lagente V et al. | Interference of the Paf antagonist Ro 19-3704 with Paf and antigen-induced bronchoconstriction in the guinea-pig. | 1988 | Br. J. Pharmacol. | pmid:3401641 |
| Groscurth P et al. | Effects of platelet activating factor (PAF) on human citrated whole blood. | 1988 | Eur. J. Haematol. | pmid:3402585 |
| Rylander R et al. | Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3403044 |
| Satoh K et al. | [Endothelial injury as an initiating factor: vascular endothelial cell injury and biosynthesis of PAF]. | 1988 | Nippon Rinsho | pmid:3404682 |
| Nogami M et al. | [Effects of a PAF antagonist CV-3988 on the acute gastric erosions of rats by water-immersion stress]. | 1988 | Nihon Shokakibyo Gakkai Zasshi | pmid:3404759 |
| Tamura N et al. | Leukotriene C4 production from human eosinophils in vitro. Role of eosinophil chemotactic factors on eosinophil activation. | 1988 | J. Immunol. | pmid:2848892 |
| Biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3405995 | |
| Pretolani M et al. | Active immunization induces lung hyperresponsiveness in the guinea pig. Pharmacologic modulation and triggering role of the booster injection. | 1988 | Am. Rev. Respir. Dis. | pmid:3202509 |
| Willuweit B and Aktories K | Heparin and heparinoids impair adrenaline and platelet-activating factor but not thrombin-induced inhibition of adenylate cyclase and stimulation of GTP hydrolysis in human platelet membranes. | 1988 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:2969081 |
| Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
| Tkhostov EB et al. | [Calcium metabolism in arterial hypertension. I. Myocardial hypertrophy and hormone-dependent increase in Ca2+ levels in the thrombocytes of patients with arterial hypertension]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:2969736 |
| Leprevost C et al. | Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2971624 |
| Ohmori K et al. | Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. | 1988 | Arzneimittelforschung | pmid:2972291 |
| Masugi F et al. | Platelet-activating factor and anti-platelet-aggregating factor in acute reduction of blood pressure following percutaneous transluminal renal angioplasty in patients with renovascular hypertension. | 1988 | J Hum Hypertens | pmid:2977405 |
| Valone FH et al. | Enhanced human monocyte cytotoxicity by platelet-activating factor. | 1988 | Immunology | pmid:3169845 |
| Popovich KJ et al. | Role of platelets in contraction of canine tracheal muscle elicited by PAF in vitro. | 1988 | J. Appl. Physiol. | pmid:3170437 |
| Moriyama T et al. | Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. | 1988 | J. Biochem. | pmid:3170519 |
| Lagente V et al. | PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3171975 |
| Danko G et al. | Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis. | 1988 | Pharmacol Res Commun | pmid:3174804 |
| Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
| Hill CE et al. | Location of platelet activating factor binding in rat liver. | 1988 | Biochem. J. | pmid:3178735 |
| Wichrowski B et al. | Structure-activity relationship in PAF-acether. 4. Synthesis and biological activities of carboxylate isosteres. | 1988 | J. Med. Chem. | pmid:3339611 |
| Tilley JW et al. | Pyrido[2,1-b]quinazolinecarboxamide derivatives as platelet activating factor antagonists. | 1988 | J. Med. Chem. | pmid:3339617 |
| Ferguson MK et al. | Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. | 1988 | J. Surg. Res. | pmid:3339877 |
| Kelefiotis D et al. | Study of digoxin as inhibitor of the in vivo effects of acetyl glyceryl ether phosphorylcholine (AGEPC) in mice. | 1988 | Life Sci. | pmid:3339951 |
| Soybel DI et al. | Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. | 1988 | Am. J. Surg. | pmid:3341532 |
| Kumar R et al. | Occurrence of platelet-activating factor in rabbit spermatozoa. | 1988 | Arch. Biochem. Biophys. | pmid:3341753 |
| Huo YN et al. | A preferential inhibition by Zn2+ on platelet activating factor- and thrombin-induced serotonin secretion from washed rabbit platelets. | 1988 | Arch. Biochem. Biophys. | pmid:3341767 |
| Brass LF et al. | Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase. | 1988 | J. Biol. Chem. | pmid:2833506 |
| Blank ML et al. | Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production. | 1988 | J. Biol. Chem. | pmid:2833508 |
| Rola-Pleszczynski M et al. | Immune regulation by platelet-activating factor. I. Induction of suppressor cell activity in human monocytes and CD8+ T cells and of helper cell activity in CD4+ T cells. | 1988 | J. Immunol. | pmid:2834440 |
| Worthen GS et al. | The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion. | 1988 | J. Immunol. | pmid:2834441 |
| Touvay C et al. | Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2835036 |
| Hofmann B et al. | Effect of specific antagonists on PAF-induced platelet aggregation and release of plasminogen activator. | 1988 | Biomed. Biochim. Acta | pmid:3248103 |
| 17th annual UCLA symposium. Abstracts: Cell activation and signal initiation: receptor and phospholipase control of inositol phosphate, PAF and eicosanoid production. | 1988 | J. Cell. Biochem. Suppl. | pmid:2835556 | |
| Mest HJ et al. | The arrhythmogenic effect of platelet activating factor (PAF) is inhibited by PAF antagonist and by substances influencing eicosanoids. | 1988 | Biomed. Biochim. Acta | pmid:3248107 |
| Wainwright CL et al. | The effects of PAF antagonists on ischaemia and reperfusion arrhythmias and ischaemia-induced platelet aggregation. | 1988 | Biomed. Biochim. Acta | pmid:3248108 |
| Dembińska-Kieć A et al. | Release of cysteinyl-leukotrienes is of minor importance in PAF induced reduction of perfusion rate in the gastric vascular bed. | 1988 | Biomed. Biochim. Acta | pmid:3248109 |
| Ostermann G et al. | Structure-activity relationships of synthetic analogues of platelet-activating factor. | 1988 | Biomed. Biochim. Acta | pmid:3248110 |
| Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
| Leslie CC et al. | Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7. | 1988 | Biochim. Biophys. Acta | pmid:3143418 |
| Egger M et al. | Human platelet electrorotation change induced by activation: inducer specificity and correlation to serotonin release. | 1988 | Biochim. Biophys. Acta | pmid:3143424 |
| Pitcock JA | Morphometric studies of the renomedullary interstitial cells. | 1988 | Am. J. Med. Sci. | pmid:3284348 |
| Hwang SB et al. | Biochemical and pharmacological characterization of L-659,989: an extremely potent, selective and competitive receptor antagonist of platelet-activating factor. | 1988 | J. Pharmacol. Exp. Ther. | pmid:2841449 |
| Parnham MJ | PAF receptors. | 1988 | Prog Biochem Pharmacol | pmid:2841664 |
| Shkhvatsabaia IK et al. | [Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients]. | 1988 | Kardiologiia | pmid:2842537 |
| Tahraoui L et al. | High affinity specific binding sites for tritiated platelet-activating factor in canine platelet membranes: counterparts of platelet-activating factor receptors mediating platelet aggregation. | 1988 | Mol. Pharmacol. | pmid:2842653 |
| Garcia JG et al. | Effect of platelet activating factor on leukocyte-endothelial cell interactions. | 1988 | Thromb. Res. | pmid:2842887 |
| Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
| Browne PC et al. | Kinetics of the formation of thrombin-thrombospondin complexes: involvement of a 77-kDa intermediate. | 1988 | Arch. Biochem. Biophys. | pmid:2844122 |
| Yamada K et al. | Highly sensitive gas chromatographic--mass spectrometric method for the determination of platelet-activating factor in human blood. | 1988 | J. Chromatogr. | pmid:3235552 |
| Birkle DL et al. | Platelet-activating factor antagonist BN52021 decreases accumulation of free polyunsaturated fatty acid in mouse brain during ischemia and electroconvulsive shock. | 1988 | J. Neurochem. | pmid:2846788 |
| Yoshikawa D and Goto F | [Interactions between platelet activating factor and leukotrienes during endotoxin shock in the rat]. | 1988 | Masui | pmid:3236398 |
| Wykle RL et al. | Platelet-activating factor. | 1988 | Meth. Enzymol. | pmid:3237085 |
| Rouis M et al. | Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847729 |
| Kioumis I et al. | Effect of inhaled platelet-activating factor on circulating neutrophils and platelets in vivo and ex vivo in man. | 1988 | Prostaglandins | pmid:3237997 |
| Doni MG et al. | Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847730 |
| Sirois MG et al. | PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655,240. | 1988 | Prostaglandins | pmid:3238010 |
| Schindler PW et al. | Fluorophore-labeled ether lipids: substrates for enzymes of the platelet-activating factor cycle in peritoneal polymorphonuclear leukocytes. | 1988 | Anal. Biochem. | pmid:3239750 |
| Silva PM et al. | Adrenalectomy exacerbates paw edema without interfering with desensitization induced by PAF-acether in rats. | 1988 | Braz. J. Med. Biol. Res. | pmid:3240383 |
| Ghigo D et al. | Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells. | 1988 | J. Biol. Chem. | pmid:2848827 |
| Aratani H et al. | Effect of etizolam (Depas) on production of superoxide anion by platelet-activating factor and N-formyl-methionyl-leucyl-phenylalanine-stimulated guinea pig polymorphonuclear leukocytes. | 1988 | Jpn. J. Pharmacol. | pmid:2848961 |
| Robertson DN et al. | The effect of platelet-activating factor on histamine and muscarinic receptor function in guinea pig airways. | 1988 | Am. Rev. Respir. Dis. | pmid:2849329 |
| Stewart AG and Dusting GJ | Characterization of receptors for platelet-activating factor on platelets, polymorphonuclear leukocytes and macrophages. | 1988 | Br. J. Pharmacol. | pmid:2850058 |