Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Moon DG et al. | Platelet modulation of neutrophil superoxide anion production. | 1990 | Thromb. Haemost. | pmid:2160133 |
Murakami K et al. | A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. | 1996 | Thromb. Haemost. | pmid:8822594 |
Koyama M et al. | Surface coverage of vascular grafts with cultured human endothelial cells from subcutaneous fat tissue obtained with a biopsy needle. | 1996 | Thromb. Haemost. | pmid:8903004 |
Prescott SM et al. | The role of platelet-activating factor in endothelial cells. | 1990 | Thromb. Haemost. | pmid:2274933 |
Hermán F et al. | In vivo antiaggregatory action of platelet-activating factor in beagle dogs: role for prostacyclin. | 1991 | Thromb. Haemost. | pmid:2048053 |
Shindo K et al. | Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor. | 1997 | Thorax | pmid:9516893 |
Chung KF | Platelet activating factor revisited. | 1997 | Thorax | pmid:9516891 |
Shindo K et al. | Priming effect of platelet activating factor on leukotriene C4 from stimulated eosinophils of asthmatic patients. | 1996 | Thorax | pmid:8711647 |
McFadden RG et al. | Effect of platelet activating factor (PAF) on the migration of human lymphocytes. | 1995 | Thorax | pmid:7660340 |
Spring J et al. | Failure of salmeterol to inhibit circulating white cell responses and bronchoconstriction induced by platelet activating factor. | 1992 | Thorax | pmid:1361250 |
Chung KF et al. | Effects of salbutamol on bronchoconstriction, bronchial hyperresponsiveness, and leucocyte responses induced by platelet activating factor in man. | 1989 | Thorax | pmid:2648645 |
Chung KF and Barnes PJ | Effects of platelet activating factor on airway calibre, airway responsiveness, and circulating cells in asthmatic subjects. | 1989 | Thorax | pmid:2648646 |
Summers C et al. | Pulmonary retention of primed neutrophils: a novel protective host response, which is impaired in the acute respiratory distress syndrome. | 2014 | Thorax | pmid:24706039 |
Spencer DA et al. | Participation of the cysteinyl leukotrienes in the acute bronchoconstrictor response to inhaled platelet activating factor in man. | 1991 | Thorax | pmid:1858084 |
Freitag A et al. | Effect of a platelet activating factor antagonist, WEB 2086, on allergen induced asthmatic responses. | 1993 | Thorax | pmid:8346486 |
Hoenderdos K et al. | Hypoxia upregulates neutrophil degranulation and potential for tissue injury. | 2016 | Thorax | pmid:27581620 |
Alabaster VA and Moore BA | New perspectives on basic mechanisms in lung disease. 3. Drug intervention in asthma: present and future. | 1993 | Thorax | pmid:8493636 |
Roudebush WE and Diehl JR | Platelet-activating factor content in boar spermatozoa correlates with fertility. | 2001 | Theriogenology | pmid:11396471 |
O' Meara CM et al. | Relationship between in vitro sperm functional tests and in vivo fertility of rams following cervical artificial insemination of ewes with frozen-thawed semen. | 2008 | Theriogenology | pmid:18248736 |
Bathgate R et al. | Effects of platelet-activating factor and platelet-activating factor: acetylhydrolase on in vitro post-thaw boar sperm parameters. | 2007 | Theriogenology | pmid:17157372 |
Kumar S and Sharma A | Platelet activating factor improves the in vitro penetration of zona free hamster eggs by buffalo (Bubalus bubalis) spermatozoa. | 2005 | Theriogenology | pmid:15763101 |
Desquand S | [Effects of PAF antagonists in experimental models. Therapeutical perspectives]. | 1993 Nov-Dec | Therapie | pmid:8091344 |
Zardini DM and Tschirhart EJ | [Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion]. | 1999 Jan-Feb | Therapie | pmid:10216433 |
Willerson JT | Conversion from chronic to acute coronary heart disease syndromes. Role of platelets and platelet products. | 1995 | Tex Heart Inst J | pmid:7787465 |
TatarskiÄ AR et al. | [Use of plateletpheresis in the treatment of bronchial asthma]. | 1991 | Ter. Arkh. | pmid:2063345 |
TatarskiÄ AR and Emirova AS | [The role of the thrombocytes in the pathogenesis of certain forms of bronchial asthma]. | 1990 | Ter. Arkh. | pmid:2142338 |
Skvortsov AA et al. | [New approaches to the study of thrombocyte aggregation in patients with dilated cardiomyopathy]. | 1989 | Ter. Arkh. | pmid:2727928 |
Miwa M | [Catabolism of PAF and its regulation]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024018 |
Oda M et al. | [PAF and diseases]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024019 |
Fukuda T and Makino S | [Allergy and PAF]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024020 |
Yanoshita R | [Phospholipid alteration and activation of phospholipase A2 in ischemic heart]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024024 |
Karasawa K and Nojima S | [Production and application of antibodies to PAF]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024029 |
Tsujimoto M and Hori T | [Activation of phospholipase A2 by cytokines]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024038 |
Ishii S and Shimizu T | [Platelet-activating factor (PAF) receptor-related pathophysiology]. | 1999 | Tanpakushitsu Kakusan Koso | pmid:10396985 |
Okiji T and Murota S | [Chemical mediators]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1901997 |
Mizoguchi H | [Erythropoietin and thrombopoietin]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1651533 |
Shindou H and Shimizu T | [New development of lysophospholipid acyltransferases]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19205351 |
Karasawa K | [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. | 2001 | Tanpakushitsu Kakusan Koso | pmid:11193332 |
Masugi F et al. | [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. | 1982 | Tanpakushitsu Kakusan Koso | pmid:6758041 |
Terasawa M | [Platelet-activating factor (PAF) antagonists]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1850862 |
Eser A et al. | Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients. | 2016 | Taiwan J Obstet Gynecol | pmid:26927250 |
Bazan NG and Allan G | Signal transduction and gene expression in the eye: a contemporary view of the pro-inflammatory, anti-inflammatory and modulatory roles of prostaglandins and other bioactive lipids. | 1997 | Surv Ophthalmol | pmid:9154273 |
Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
Kim FJ et al. | Disparate signal transduction in neutrophil CD18 adhesion receptor expression versus superoxide generation. | 1994 | Surgery | pmid:8047994 |
Schurr MJ et al. | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1997 | Surgery | pmid:9142146 |
Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
Wang KS et al. | Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats. | 1993 | Surgery | pmid:8417492 |