Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Leukemia, Myeloid, Acute D015470 19 associated lipids
Leukemia, Myelogenous, Chronic, BCR-ABL Positive D015464 17 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Weight Loss D015431 56 associated lipids
Weight Gain D015430 101 associated lipids
Reperfusion Injury D015427 65 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Dementia, Multi-Infarct D015161 2 associated lipids
Xeroderma Pigmentosum D014983 6 associated lipids
Wounds and Injuries D014947 20 associated lipids
Granulomatosis with Polyangiitis D014890 5 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Viremia D014766 4 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Uremia D014511 33 associated lipids
Tumor Virus Infections D014412 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Ichinose M et al. Activation of K+ current in macrophages by platelet activating factor. 1992 Biochem. Biophys. Res. Commun. pmid:1370616
Rezaul K et al. Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. 1997 Biochem. Biophys. Res. Commun. pmid:9345263
Iwamoto S et al. The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. 1997 Biochem. Biophys. Res. Commun. pmid:9345277
Mutoh H et al. Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B. 1994 Biochem. Biophys. Res. Commun. pmid:7802642
Agrawal DK and Townley RG Effect of platelet-activating factor on beta-adrenoceptors in human lung. 1987 Biochem. Biophys. Res. Commun. pmid:3030311
Hwang SB Competitive inhibition of tritium-labeled platelet-activating factor binding to rabbit platelet membranes by amiloride and amiloride analogs. 1989 Biochem. Biophys. Res. Commun. pmid:2549986
Kuruvilla A et al. High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. 1991 Biochem. Biophys. Res. Commun. pmid:1659411
Lee TC et al. Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in the rat kidney inner medulla. 1989 Biochem. Biophys. Res. Commun. pmid:2551264
Tysnes OB et al. Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. 1987 Biochem. Biophys. Res. Commun. pmid:3034251
Catalán RE et al. Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. 1993 Biochem. Biophys. Res. Commun. pmid:8484756
Asano K et al. Distribution of platelet activating factor receptor mRNA along the rat nephron segments. 1996 Biochem. Biophys. Res. Commun. pmid:8753768
el Azzouzi B et al. Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature T cell line. 1993 Biochem. Biophys. Res. Commun. pmid:8427577
Smith RJ et al. Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. 1984 Biochem. Biophys. Res. Commun. pmid:6329191
Dillon AM and Heath MF The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. 1995 Biochem. Biophys. Res. Commun. pmid:7542881
Liu B et al. Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. 1995 Biochem. Biophys. Res. Commun. pmid:7677747
Rengan R and Omann GM Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10462500
Lerner R et al. Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. 1988 Biochem. Biophys. Res. Commun. pmid:2838025
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
Maridonneau-Parini I et al. Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. 1985 Biochem. Biophys. Res. Commun. pmid:2994661
García-Sáinz JA and Hernández-Sotomayor SM Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. 1985 Biochem. Biophys. Res. Commun. pmid:3933497
Chiang CF and Hauser G Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. 1989 Biochem. Biophys. Res. Commun. pmid:2686644
López-Farré A et al. Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. 1988 Biochem. Biophys. Res. Commun. pmid:3358756
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Clay KL et al. Structure elucidation of platelet activating factor derived from human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6430285
Alexandre A et al. Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. 1986 Biochem. Biophys. Res. Commun. pmid:3094518
Kuiper J et al. The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. 1988 Biochem. Biophys. Res. Commun. pmid:3144970
Lanara E et al. Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. 1982 Biochem. Biophys. Res. Commun. pmid:7168759
O'Flaherty JT et al. Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. 1984 Biochem. Biophys. Res. Commun. pmid:6433920
O'Flaherty JT et al. Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. 1981 Biochem. Biophys. Res. Commun. pmid:6277309
Blank ML et al. Generation of the precursor (lyso-PAF) of platelet-activating factor via a CoA-dependent transacylase. 1995 Biochem. Biophys. Res. Commun. pmid:7763233
Mendlovic F et al. Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. 1984 Biochem. Biophys. Res. Commun. pmid:6435614
Tokumura A et al. Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. 1987 Biochem. Biophys. Res. Commun. pmid:3593346
Kojima S et al. Cooperativity between platelet-activating factor and collagen in platelet aggregation. 1987 Biochem. Biophys. Res. Commun. pmid:3593379
Lad PM et al. Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. 1985 Biochem. Biophys. Res. Commun. pmid:2990462
Comminges C et al. Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. 1996 Biochem. Biophys. Res. Commun. pmid:8607782
Weber C et al. Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. 1993 Biochem. Biophys. Res. Commun. pmid:8373423
Franklin RA et al. Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. 1995 Biochem. Biophys. Res. Commun. pmid:7733966
Hayashi M et al. Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. 1992 Biochem. Biophys. Res. Commun. pmid:1445360
Svetlov S and Nigam S Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. 1993 Biochem. Biophys. Res. Commun. pmid:8380690
Domingo MT et al. Characterization of specific binding sites for PAF in the iris and ciliary body of rabbit. 1989 Biochem. Biophys. Res. Commun. pmid:2540746
Griffin K et al. The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086. 1989 Biochem. Biophys. Res. Commun. pmid:2540748
White GC Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. 1984 Biochem. Biophys. Res. Commun. pmid:6428395
Schlondorff D et al. Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. 1986 Biochem. Biophys. Res. Commun. pmid:3099783
Satouchi K et al. Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. 1985 Biochem. Biophys. Res. Commun. pmid:4004866
Resink T et al. Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. 1996 Biochem. Biophys. Res. Commun. pmid:8651917
Francescangeli E and Goracci G The de novo biosynthesis of platelet-activating factor in rat brain. 1989 Biochem. Biophys. Res. Commun. pmid:2543404
Hussaini IM and Shen TY A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. 1989 Biochem. Biophys. Res. Commun. pmid:2543410
Weintraub ST et al. Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1985 Biochem. Biophys. Res. Commun. pmid:4015656
Shukla SD and Hanahan DJ AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6288030
Doebber TW et al. Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6517949
Fernández B and Balsinde J Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. 1991 Biochem. Biophys. Res. Commun. pmid:1659393
Kok PT et al. Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. 1988 Biochem. Biophys. Res. Commun. pmid:3132917
Silva-Neto MA et al. Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. 2002 Biochem. Biophys. Res. Commun. pmid:12054663
Shindou H et al. Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. 2000 Biochem. Biophys. Res. Commun. pmid:10814544
Lagente V et al. Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig. 1989 Biochem. Biophys. Res. Commun. pmid:2645865
Mollinedo F et al. Intracellular localization of platelet-activating factor synthesis in human neutrophils. 1988 Biochem. Biophys. Res. Commun. pmid:3408495
Joseph R and Han E Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons. 1992 Biochem. Biophys. Res. Commun. pmid:1590803
Hirafuji M et al. Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. 1988 Biochem. Biophys. Res. Commun. pmid:3408504
Pinckard RN et al. Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. 1984 Biochem. Biophys. Res. Commun. pmid:6743335
Rigat B et al. GM2 activator protein inhibits platelet activating factor signaling in rats. 2009 Biochem. Biophys. Res. Commun. pmid:19486886
Kato T et al. Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). 1988 Biochem. Biophys. Res. Commun. pmid:3202869
Blank ML et al. A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. 1984 Biochem. Biophys. Res. Commun. pmid:6696762
Takano T et al. Demonstration of platelet activating factor receptor in guinea pig kidney. 1991 Biochem. Biophys. Res. Commun. pmid:1710454
Lüthje J and Ogilvie A Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. 1984 Biochem. Biophys. Res. Commun. pmid:6704102
Patrignani P et al. Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. 1987 Biochem. Biophys. Res. Commun. pmid:2825672
Fisher GJ et al. Differential activation of human skin cells by platelet activating factor: stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts. 1989 Biochem. Biophys. Res. Commun. pmid:2476985
Földes-Filep E et al. Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. 1987 Biochem. Biophys. Res. Commun. pmid:2825685
Di Marzo V et al. Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. 1987 Biochem. Biophys. Res. Commun. pmid:2822041
Crouch MF and Lapetina EG Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. 1988 Biochem. Biophys. Res. Commun. pmid:3178827
Joly F et al. Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. 1992 Biochem. Biophys. Res. Commun. pmid:1317174
Molski TF et al. Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. 1988 Biochem. Biophys. Res. Commun. pmid:3348814
Chen JJ and Liew CC Phosphorylation of an acid-soluble nuclear protein in response to catecholamine in cultured rat cardiocytes. 1993 Biochem. Biophys. Res. Commun. pmid:8439325
Sugiura T et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. 1996 Biochem. Biophys. Res. Commun. pmid:8954083
Touqui L et al. Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. 1983 Biochem. Biophys. Res. Commun. pmid:6838557
Smith CS et al. Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes. 1994 Biochem. Biophys. Res. Commun. pmid:7524500
Scherer GF 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. 1985 Biochem. Biophys. Res. Commun. pmid:4084306
Hsu HC et al. Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. 2006 Biochem. Biophys. Res. Commun. pmid:16712790
Waga I et al. Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. 1993 Biochem. Biophys. Res. Commun. pmid:8267581
Levi R et al. Alkyl chain homologs of platelet-activating factor and their effects on the mammalian heart. 1989 Biochem. Biophys. Res. Commun. pmid:2742592
Touvay C et al. Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. 1988 Biochem. Biophys. Res. Commun. pmid:2835036
Yamada T et al. Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. 1991 Biochem. Biophys. Res. Commun. pmid:2025290
Diserbo M et al. Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. 1996 Biochem. Biophys. Res. Commun. pmid:8579584
Iwamoto S et al. Platelet microparticles: a carrier of platelet-activating factor? 1996 Biochem. Biophys. Res. Commun. pmid:8579618
Yang JP and Tashjian AH Platelet-activating factor affects cytosolic free calcium concentration and prolactin secretion in GH4C1 rat pituitary cells. 1991 Biochem. Biophys. Res. Commun. pmid:1847044
Matsumoto T et al. G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. 1987 Biochem. Biophys. Res. Commun. pmid:3032170
O'Flaherty JT and Jacobson D Protein kinase C blockers and neutrophil receptors for leukotriene B4. 1989 Biochem. Biophys. Res. Commun. pmid:2551291
Ng DS and Wong K Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. 1988 Biochem. Biophys. Res. Commun. pmid:2843182
Dewald B and Baggiolini M Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. 1985 Biochem. Biophys. Res. Commun. pmid:2985075
Rigat B et al. The GM2 activator protein, a novel inhibitor of platelet-activating factor. 1999 Biochem. Biophys. Res. Commun. pmid:10329374
Inui H et al. Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. 1994 Biochem. Biophys. Res. Commun. pmid:7802667
Hartiala KT et al. Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. 1987 Biochem. Biophys. Res. Commun. pmid:3034265
Gomez-Cambronero J et al. The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. 1987 Biochem. Biophys. Res. Commun. pmid:2823810
Smith RJ and Bowman BJ Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. 1982 Biochem. Biophys. Res. Commun. pmid:6803804
Wirthmueller U et al. Receptor-operated activation of polymorphonuclear leukocytes: different effects of NAP-1/IL-8 and fMet-Leu-Phe or C5a. 1991 Biochem. Biophys. Res. Commun. pmid:1645549
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Nishinaka Y et al. A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. 1993 Biochem. Biophys. Res. Commun. pmid:8390246
Shiono S et al. Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. 1993 Biochem. Biophys. Res. Commun. pmid:8390248
Billah MM and Siegel MI Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. 1984 Biochem. Biophys. Res. Commun. pmid:6422930
Ng DS and Wong K GTP regulation of platelet-activating factor binding to human neutrophil membranes. 1986 Biochem. Biophys. Res. Commun. pmid:3026378
Prevost MC et al. Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. 1984 Biochem. Biophys. Res. Commun. pmid:6422938