Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ichinose M et al. | Activation of K+ current in macrophages by platelet activating factor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1370616 |
Rezaul K et al. | Platelet-activating factor stimulates calcium-dependent activation of protein-tyrosine kinase Syk in a human B cell line. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345263 |
Iwamoto S et al. | The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345277 |
Mutoh H et al. | Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7802642 |
Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
Hwang SB | Competitive inhibition of tritium-labeled platelet-activating factor binding to rabbit platelet membranes by amiloride and amiloride analogs. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2549986 |
Kuruvilla A et al. | High-level expression of functional platelet-activating factor receptors on a human B lymphoblastoid cell line. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659411 |
Lee TC et al. | Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in the rat kidney inner medulla. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551264 |
Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
Catalán RE et al. | Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8484756 |
Asano K et al. | Distribution of platelet activating factor receptor mRNA along the rat nephron segments. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753768 |
el Azzouzi B et al. | Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature T cell line. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8427577 |
Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
Dillon AM and Heath MF | The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7542881 |
Liu B et al. | Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677747 |
Rengan R and Omann GM | Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462500 |
Lerner R et al. | Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2838025 |
Steiner M et al. | Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3936503 |
Maridonneau-Parini I et al. | Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994661 |
GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
Chiang CF and Hauser G | Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2686644 |
López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
Lachachi H et al. | Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998370 |
Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
Alexandre A et al. | Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3094518 |
Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
Lanara E et al. | Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7168759 |
O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
O'Flaherty JT et al. | Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6277309 |
Blank ML et al. | Generation of the precursor (lyso-PAF) of platelet-activating factor via a CoA-dependent transacylase. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7763233 |
Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
Tokumura A et al. | Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593346 |
Kojima S et al. | Cooperativity between platelet-activating factor and collagen in platelet aggregation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593379 |
Lad PM et al. | Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2990462 |
Comminges C et al. | Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607782 |
Weber C et al. | Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8373423 |
Franklin RA et al. | Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733966 |
Hayashi M et al. | Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445360 |
Svetlov S and Nigam S | Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8380690 |
Domingo MT et al. | Characterization of specific binding sites for PAF in the iris and ciliary body of rabbit. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2540746 |
Griffin K et al. | The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2540748 |
White GC | Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428395 |
Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
Resink T et al. | Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8651917 |
Francescangeli E and Goracci G | The de novo biosynthesis of platelet-activating factor in rat brain. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543404 |
Hussaini IM and Shen TY | A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543410 |
Weintraub ST et al. | Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4015656 |
Shukla SD and Hanahan DJ | AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6288030 |
Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
Fernández B and Balsinde J | Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659393 |
Kok PT et al. | Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132917 |
Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
Lagente V et al. | Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2645865 |
Mollinedo F et al. | Intracellular localization of platelet-activating factor synthesis in human neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408495 |
Joseph R and Han E | Amyloid beta-protein fragment 25-35 causes activation of cytoplasmic calcium in neurons. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1590803 |
Hirafuji M et al. | Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408504 |
Pinckard RN et al. | Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743335 |
Rigat B et al. | GM2 activator protein inhibits platelet activating factor signaling in rats. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486886 |
Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
Blank ML et al. | A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696762 |
Takano T et al. | Demonstration of platelet activating factor receptor in guinea pig kidney. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1710454 |
Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
Fisher GJ et al. | Differential activation of human skin cells by platelet activating factor: stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2476985 |
Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
Di Marzo V et al. | Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2822041 |
Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
Joly F et al. | Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1317174 |
Molski TF et al. | Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3348814 |
Chen JJ and Liew CC | Phosphorylation of an acid-soluble nuclear protein in response to catecholamine in cultured rat cardiocytes. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8439325 |
Sugiura T et al. | 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954083 |
Touqui L et al. | Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6838557 |
Smith CS et al. | Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7524500 |
Scherer GF | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084306 |
Hsu HC et al. | Alpha-bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16712790 |
Waga I et al. | Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267581 |
Levi R et al. | Alkyl chain homologs of platelet-activating factor and their effects on the mammalian heart. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2742592 |
Touvay C et al. | Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2835036 |
Yamada T et al. | Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2025290 |
Diserbo M et al. | Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579584 |
Iwamoto S et al. | Platelet microparticles: a carrier of platelet-activating factor? | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579618 |
Yang JP and Tashjian AH | Platelet-activating factor affects cytosolic free calcium concentration and prolactin secretion in GH4C1 rat pituitary cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1847044 |
Matsumoto T et al. | G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3032170 |
O'Flaherty JT and Jacobson D | Protein kinase C blockers and neutrophil receptors for leukotriene B4. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551291 |
Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
Dewald B and Baggiolini M | Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985075 |
Rigat B et al. | The GM2 activator protein, a novel inhibitor of platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10329374 |
Inui H et al. | Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7802667 |
Hartiala KT et al. | Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034265 |
Gomez-Cambronero J et al. | The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2823810 |
Smith RJ and Bowman BJ | Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803804 |
Wirthmueller U et al. | Receptor-operated activation of polymorphonuclear leukocytes: different effects of NAP-1/IL-8 and fMet-Leu-Phe or C5a. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1645549 |
Tou J | Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3921017 |
Nishinaka Y et al. | A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390246 |
Shiono S et al. | Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390248 |
Billah MM and Siegel MI | Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422930 |
Ng DS and Wong K | GTP regulation of platelet-activating factor binding to human neutrophil membranes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3026378 |
Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |