Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Iwamoto S et al. | The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9345277 |
Palmblad J et al. | Leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2154222 |
Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
Hwang SB | Competitive inhibition of tritium-labeled platelet-activating factor binding to rabbit platelet membranes by amiloride and amiloride analogs. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2549986 |
Lee TC et al. | Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in the rat kidney inner medulla. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551264 |
Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
Hirata F et al. | IL-1 beta regulates the expression of the Gi2 alpha gene via lipid mediators in guinea pig tracheal muscle. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7945342 |
Wang F et al. | A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8447826 |
O'Flaherty JT et al. | 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6403011 |
Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
Dillon AM and Heath MF | The effects of tyrphostins B42 and B46 on equine platelet function and protein tyrosine phosphorylation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7542881 |
O'Flaherty JT et al. | 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820395 |
Wymann MP et al. | Oscillatory motion in human neutrophils responding to chemotactic stimuli. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820398 |
Sozzani S et al. | Synergism between platelet activating factor and C-C chemokines for arachidonate release in human monocytes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7510961 |
Yasuda K et al. | Platelet-activating factor in normal rat uterus. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3753495 |
Jamil KM et al. | Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). | 1992 | Biochem. Biophys. Res. Commun. | pmid:1326956 |
Yeo YK et al. | The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543394 |
Wirthmueller U et al. | Studies on the mechanism of platelet-activating factor production in GM-CSF primed neutrophils: involvement of protein synthesis and phospholipase A2 activation. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2166499 |
Chiang CF and Hauser G | Effects of bradykinin, GTP gamma S, R59022 and N-ethylmaleimide on inositol phosphate production in NG108-15 cells. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2686644 |
Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
Lachachi H et al. | Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2998370 |
Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
Alexandre A et al. | Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3094518 |
O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
Domingo MT et al. | Characterization of specific binding sites for PAF in the iris and ciliary body of rabbit. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2540746 |
Griffin K et al. | The benzodiazepine receptor ligands RO 5-4864 and RO 15-1788 do not block the inhibition of PAF-induced platelet aggregation seen with the hetrazepine WEB2086. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2540748 |
Müller S and Nigam S | Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1335246 |
Ashmore RC et al. | Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302246 |
Sugimoto T et al. | Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1281995 |
Francescangeli E and Goracci G | The de novo biosynthesis of platelet-activating factor in rat brain. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543404 |
Hussaini IM and Shen TY | A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543410 |
Shukla SD and Hanahan DJ | AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6288030 |
Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
Mallet AI and Cunningham FM | Structural identification of platelet activating factor in psoriatic scale. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970690 |
Valone FH | Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970703 |
Chesney CM et al. | Desensitization of human platelets by platelet activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977920 |
Nakayama R et al. | Generation of acetyl glyceryl ether phosphorylcholine from the rat skin and muscle tissues stimulated by moxibustion. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3977939 |
Swendsen CL et al. | 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407484 |
Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
Lagente V et al. | Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2645865 |
Mollinedo F et al. | Intracellular localization of platelet-activating factor synthesis in human neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408495 |
Hirafuji M et al. | Transient increase of cytosolic free calcium in cultured human vascular endothelial cells by platelet-activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3408504 |
Barr R et al. | The effect of platelet activating factor on electron transport of spinach chloroplasts. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3048258 |
Catalán RE et al. | PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1311925 |
Pai JK et al. | Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3422154 |
Blank ML et al. | A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn-glycerols, a precursor of platelet activating factor. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6696762 |
Takano T et al. | Demonstration of platelet activating factor receptor in guinea pig kidney. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1710454 |
Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
Lee TC et al. | Activities of enzymes that metabolize platelet-activating factor (1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6808993 |
Panetta T et al. | Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827647 |
Tamura N et al. | Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030295 |
Molski TF et al. | Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3348814 |
Billah MM and Johnston JM | Identification of phospholipid platelet-activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human amniotic fluid and urine. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6407483 |
Waga I et al. | Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267581 |
Hasegawa A et al. | Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29269296 |
Chignard M et al. | Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6437404 |
Yang JP and Tashjian AH | Platelet-activating factor affects cytosolic free calcium concentration and prolactin secretion in GH4C1 rat pituitary cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1847044 |
Mueller HW et al. | Synthesis of 1-acyl-2-[3H]acetyl-SN-glycero-3-phosphocholine, a structural analog of platelet activating factor, by vascular endothelial cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2039529 |
Alaei P et al. | Inhibition of protein prenylation down-regulates signalling by inflammatory mediators in human keratinocytes. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630058 |
Parent JL et al. | Mutation of an aspartate at position 63 in the human platelet-activating factor receptor augments binding affinity but abolishes G-protein-coupling and inositol phosphate production. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8645288 |
Rigat B et al. | The GM2 activator protein, a novel inhibitor of platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10329374 |
Pannocchia A and Hardisty RM | Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2983714 |
Parent JL and Stankova J | Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8280163 |
Holtzman MJ et al. | Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2043121 |
Tokumura A et al. | Identification of sn-2-omega-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2043133 |
McNicol A et al. | Evidence for two mechanisms of thrombin-induced platelet activation: one proteolytic, one receptor mediated. | 1989 | Biochem. Cell Biol. | pmid:2551347 |
Salari H et al. | Two different sites of action for platelet activating factor and 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholine on platelets and leukemic cells. | 1992 | Biochem. Cell Biol. | pmid:1324692 |
Siegel A and Baker RR | Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia. | 1996 | Biochem. Cell Biol. | pmid:8883840 |
Holub BJ et al. | Dietary lipid modification of renal disorders and ether phospholipid metabolism. | 1991 | Biochem. Cell Biol. | pmid:1793559 |
Ali S and Bittman R | Synthesis of optically active 1-acyl-2-O-alkyl-sn-glycero-3-phosphocholine via 1-O-benzyl-sn-glycerol 3-arenesulfonate. | 1990 | Biochem. Cell Biol. | pmid:2350497 |
Shen K et al. | Properties of circulating leukocytes in spontaneously hypertensive rats. | 1995 Jul-Aug | Biochem. Cell Biol. | pmid:8703419 |
Evans RD and Williamson DH | Signals, mechanisms, and function of the acute lipid response to sepsis. | 1991 May-Jun | Biochem. Cell Biol. | pmid:1910732 |
Eckford PD and Sharom FJ | P-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors. | 2006 | Biochem. Cell Biol. | pmid:17215888 |
Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
Tselepis A et al. | Effects of AGEPC on the intracellular levels of ions in Tetrahymena pyriformis. | 1986 | Biochem. Int. | pmid:3099798 |
Ou M et al. | Simple and rapid measurement of platelet-activating factor (PAF) in whole blood. | 1991 | Biochem. Int. | pmid:1776951 |
Mabuchi K et al. | Differential effects of platelet-activating factor on superoxide anion production in human eosinophils and neutrophils. | 1992 | Biochem. Int. | pmid:1321621 |
Di Marzo V et al. | The effect of vasoactive intestinal peptide and calcitonin gene-related peptide on peptidoleukotriene release from platelet activating factor stimulated rat lungs and ionophore stimulated guinea pig lungs. | 1986 | Biochem. Int. | pmid:2432897 |
Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
Wang H et al. | Regulation of platelet-activating factor receptor gene expression in vivo by endotoxin, platelet-activating factor and endogenous tumour necrosis factor. | 1997 | Biochem. J. | pmid:9065783 |
Gómez-Cambronero J et al. | The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). | 1984 | Biochem. J. | pmid:6146309 |
Kloprogge E and Akkerman JW | Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. | 1984 | Biochem. J. | pmid:6150705 |
Chao W et al. | Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187. | 1989 | Biochem. J. | pmid:2494988 |
Tool AT et al. | Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils. | 1999 | Biochem. J. | pmid:10229663 |
Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
Touqui L et al. | Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. | 1985 | Biochem. J. | pmid:4052028 |
Kjeldsen L et al. | Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. | 1992 | Biochem. J. | pmid:1332677 |
Bauldry SA and Wooten RE | Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2. | 1997 | Biochem. J. | pmid:9065750 |
Tao W et al. | Arachidonic acid release in rabbit neutrophils. | 1989 | Biochem. J. | pmid:2494986 |
Dunlop ME and Larkins RG | Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin II, platelet-activating factor and endothelin is attenuated by prostaglandin E2. | 1990 | Biochem. J. | pmid:2268285 |
Liu B et al. | Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. | 1997 | Biochem. J. | pmid:9355758 |
Kang JX et al. | Characterization of platelet-activating factor binding to human airway epithelial cells: modulation by fatty acids and ion-channel blockers. | 1994 | Biochem. J. | pmid:7526847 |
Churchill L et al. | Interaction of platelet-activating factor with cultured guinea pig tracheal epithelial cells. | 1991 | Biochem. J. | pmid:2064601 |
Krump E et al. | Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx. | 1995 | Biochem. J. | pmid:7654211 |
Altin JG et al. | Evidence that Ca2+ fluxes and respiratory, glycogenolytic and vasoconstrictive effects induced by the action of platelet-activating factor and L-alpha-lysophosphatidylcholine in the perfused rat liver are mediated by products of the cyclo-oxygenase pathway. | 1987 | Biochem. J. | pmid:3117040 |
Rice SQ et al. | Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. | 1998 | Biochem. J. | pmid:9494101 |