Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lee T et al. | Increased biosynthesis of platelet-activating factor in activated human eosinophils. | 1984 | J. Biol. Chem. | pmid:6425292 |
| Hallam TJ et al. | Stimulus-response coupling in human platelets. Changes evoked by platelet-activating factor in cytoplasmic free calcium monitored with the fluorescent calcium indicator quin2. | 1984 | Biochem. J. | pmid:6426464 |
| Gómez-Cambronero J et al. | The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). | 1984 | Biochem. J. | pmid:6146309 |
| Morley J et al. | The platelet in asthma. | 1984 | Lancet | pmid:6150192 |
| Kloprogge E and Akkerman JW | Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. | 1984 | Biochem. J. | pmid:6150705 |
| Hanahan DJ and Nelson DR | Phospholipids as dynamic participants in biological processes. | 1984 | J. Lipid Res. | pmid:6152281 |
| Lewis AJ et al. | The effects of antiallergic and bronchodilator drugs on platelet-activating factor (PAF-acether) induced bronchospasm and platelet aggregation. | 1984 | Agents Actions | pmid:6152379 |
| Malpass TW et al. | The effect of prostacyclin infusion on platelet hemostatic function in patients undergoing cardiopulmonary bypass. | 1984 | J. Thorac. Cardiovasc. Surg. | pmid:6231433 |
| Willoughby WF and Willoughby JB | Immunologic mechanisms of parenchymal lung injury. | 1984 | Environ. Health Perspect. | pmid:6234162 |
| Handley DA et al. | Effect of platelet activating factor on endothelial permeability to plasma macromolecules. | 1984 | Immunopharmacology | pmid:6083990 |
| Camussi G et al. | Effect of platelet activating factor on guinea-pig papillary muscle. | 1984 | Experientia | pmid:6086382 |
| Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
| Pirotzky E et al. | PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. | 1984 | Microcirc Endothelium Lymphatics | pmid:6546141 |
| Bussolino F et al. | Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell. | 1984 | Cell Calcium | pmid:6549153 |
| Pirotzky E et al. | Biosynthesis of platelet-activating factor. VI. Precursor of platelet-activating factor and acetyltransferase activity in isolated rat kidney cells. | 1984 | Lab. Invest. | pmid:6492758 |
| Handley DA et al. | Evaluation of dose and route effects of platelet activating factor-induced extravasation in the guinea pig. | 1984 | Thromb. Haemost. | pmid:6495262 |
| Riess H and Hiller E | Heparin and thrombocytopenia. | 1984 | Ann. Intern. Med. | pmid:6497200 |
| Blank ML et al. | Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497876 |
| Lichey J et al. | Pressure effects and uptake of platelet-activating factor in isolated rat lung. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6501025 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
| Söling HD et al. | Acetylcholine-like effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ('platelet-activating factor') and its analogues in exocrine secretory glands. | 1984 | Eur. J. Biochem. | pmid:6207023 |
| Jouvin-Marche E et al. | Biosynthesis of Paf-acether (platelet-activating factor). VII. Precursors of Paf-acether and acetyl-transferase activity in human leukocytes. | 1984 | J. Immunol. | pmid:6736649 |
| Renal syndromes and nonsteroidal antiinflammatory drugs. | 1984 | N. Engl. J. Med. | pmid:6738607 | |
| Hoffman DR et al. | Cytotoxicity of ether-linked phytanyl phospholipid analogs and related derivatives in human HL-60 leukemia cells and polymorphonuclear neutrophils. | 1984 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:6739956 |
| Mohanty D and Hilgard P | A new platelet aggregating material (PAM) in an experimentally induced rat fibrosarcoma. | 1984 | Thromb. Haemost. | pmid:6740552 |
| Lalau Keraly C et al. | Inhibition by ticlopidine of Paf-acether-induced in vitro aggregation of rabbit and human platelets. | 1984 | Thromb. Res. | pmid:6740569 |
| Ostermann G et al. | Halo lipids. VI. Stimulation of human and rabbit blood platelets by racemic halo analogues of O-alkyl-glycerophosphocholine. | 1984 | Biomed. Biochim. Acta | pmid:6743307 |
| Pinckard RN et al. | Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743335 |
| Kramer RM et al. | Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. | 1984 | J. Biol. Chem. | pmid:6436245 |
| Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
| Chignard M et al. | Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6437404 |
| O'Neill C and Saunders DM | Assessment of embryo quality. | 1984 | Lancet | pmid:6149413 |
| Infante JP | Biosynthesis of acyl-specific glycerophospholipids in mammalian tissues. Postulation of new pathways. | 1984 | FEBS Lett. | pmid:6373368 |
| Camussi G et al. | Platelet-activating factor-induced loss of glomerular anionic charges. | 1984 | Kidney Int. | pmid:6374251 |
| Vargaftig BB et al. | [Platelet aggregation and PAF-acether. Pharmacologic interference]. | 1984 | J Pharmacol | pmid:6374298 |
| Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |
| Wodzinowska B and Krajewski T | [Role of blood platelets and their membrane in the process of hemostasis]. | 1984 Jan-Feb | Postepy Hig Med Dosw | pmid:6093087 |
| Vemulapalli S et al. | Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. | 1984 Jul-Aug | Hypertension | pmid:6378787 |
| Cox CP et al. | VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). | 1984 Mar-Apr | Peptides | pmid:6206481 |
| McIntyre TM et al. | Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. | 1985 | J. Clin. Invest. | pmid:2862164 |
| Archer CB et al. | Effects of serum albumin, indomethacin and histamine H1-antagonists on Paf-acether-induced inflammatory responses in the skin of experimental animals and man. | 1985 | Br. J. Pharmacol. | pmid:2862936 |
| Sturk A et al. | Synergistic effects of platelet-activating factor and other platelet agonists in human platelet aggregation and release: the role of ADP and products of the cyclooxygenase pathway. | 1985 | Thromb. Res. | pmid:2934863 |
| Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
| Davis JW et al. | Effects of tobacco and non-tobacco cigarette smoking on endothelium and platelets. | 1985 | Clin. Pharmacol. Ther. | pmid:3987176 |
| Foa R et al. | Release of platelet-activating factor in human leukemia. | 1985 | Cancer Res. | pmid:3861246 |
| Otsuka A et al. | Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. | 1985 | Prostaglandins Leukot Med | pmid:3862138 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3159192 |
| Zimmerman GA et al. | Production of platelet-activating factor by human vascular endothelial cells: evidence for a requirement for specific agonists and modulation by prostacyclin. | 1985 | Circulation | pmid:3928193 |
| Archer CB et al. | Inflammatory cell accumulation in response to intracutaneous Paf-acether: a mediator of acute and persistent inflammation? | 1985 | Br. J. Dermatol. | pmid:4015978 |
| Valone FH and Johnson B | Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. | 1985 | Thromb. Res. | pmid:4082115 |