| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kulinski JM et al. | Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. | 2016 | Eur. J. Pharmacol. | pmid:25941085 |
| Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
| Eleftheriou K et al. | Comparative Experimental and Computational Study of Monoalkyl Chain Phosphatidylcholine-Containing Thermoresponsive Liposomes. | 2016 | J Phys Chem B | pmid:27280363 |
| Vadas P | The platelet-activating factor pathway in food allergy and anaphylaxis. | 2016 | Ann. Allergy Asthma Immunol. | pmid:27788869 |
| Pike DP et al. | Platelet-Activating Factor Quantification Using Reversed Phase Liquid Chromatography and Selected Reaction Monitoring in Negative Ion Mode. | 2016 | Lipids | pmid:27757707 |
| Täubel J et al. | Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial. | 2016 | PLoS ONE | pmid:27632557 |
| Hoenderdos K et al. | Hypoxia upregulates neutrophil degranulation and potential for tissue injury. | 2016 | Thorax | pmid:27581620 |
| Watanabe M et al. | Characterization of platelet-activating factor-induced cutaneous edema and erythema in dogs. | 2016 | Am. J. Vet. Res. | pmid:27580108 |
| González-Núñez V et al. | Rupatadine: global safety evaluation in allergic rhinitis and urticaria. | 2016 | Expert Opin Drug Saf | pmid:27500993 |
| Kamaladasa A et al. | Lipopolysaccharide acts synergistically with the dengue virus to induce monocyte production of platelet activating factor and other inflammatory mediators. | 2016 | Antiviral Res. | pmid:27476044 |
| Schauberger E et al. | Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets. | 2016 | Curr Allergy Asthma Rep | pmid:27333777 |
| Wang JM and Chen J | Damage of vascular endothelial barrier induced by explosive blast and its clinical significance. | 2016 | Chin. J. Traumatol. | pmid:27321288 |
| Wang M et al. | The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice. | 2016 | Life Sci. | pmid:26808090 |
| Reiner B et al. | Platelet-activating factor attenuation of long-term potentiation in rat hippocampal slices via protein tyrosine kinase signaling. | 2016 | Neurosci. Lett. | pmid:26808643 |
| Unsal E et al. | Effects of pentoxifylline and platelet activating factor on sperm DNA damage. | 2016 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:26748389 |
| Park JH et al. | Glucosamine suppresses platelet-activating factor-induced activation of microglia through inhibition of store-operated calcium influx. | 2016 | Environ. Toxicol. Pharmacol. | pmid:26745504 |
| RodrÃguez M et al. | Pharmacological inhibition of eicosanoids and platelet-activating factor signaling impairs zymosan-induced release of IL-23 by dendritic cells. | 2016 | Biochem. Pharmacol. | pmid:26673542 |
| Aquino EN et al. | Proteomic Analysis of Neutrophil Priming by PAF. | 2016 | Protein Pept. Lett. | pmid:26631175 |
| Anandi VL et al. | Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures. | 2016 | Oncol. Rep. | pmid:26531049 |
| Wright NR et al. | Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. | 2016 | Am. J. Med. | pmid:26524710 |