| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Partrick DA et al. | Hypertonic saline activates lipid-primed human neutrophils for enhanced elastase release. | 1998 | J Trauma | pmid:9555828 |
| Cherniad'eva IF et al. | [Characteristics of development of oxidative stress in blood plasma of patients with familial hypercholesterolemia]. | 1998 | Biull Eksp Biol Med | pmid:9559141 |
| Lallès JP et al. | Small intestinal motility disorders in preruminant calves chronically fed a diet based on antigenic soya: characterization and possible mediators. | 1998 Jan-Feb | Vet. Res. | pmid:9559521 |
| Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
| Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
| Heller A et al. | Lipid mediators in inflammatory disorders. | 1998 | Drugs | pmid:9561339 |
| Wei Y et al. | Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution. | 1998 | Structure | pmid:9562561 |
| Akiyama M et al. | Identification of a major PAF acetylhydrolase in human serum/plasma as a 43 kDa glycoprotein containing about 9 kDa asparagine-conjugated sugar chain(s). | 1998 | J. Biochem. | pmid:9562606 |
| da Silva MB et al. | Effect of ketoprofen on PAF-induced bovine platelet aggregation. | 1998 | Vet. J. | pmid:9564275 |
| Brunet J et al. | In vitro antioxidant properties of calcium dobesilate. | 1998 | Fundam Clin Pharmacol | pmid:9565776 |
| Ezeamuzie CI et al. | The effect of salmeterol on human eosinophils is both stimulus- and response-dependent. | 1997 | Int. J. Immunopharmacol. | pmid:9568547 |
| Ruiz-Ortega M et al. | Overexpression of extracellular matrix proteins in renal tubulointerstitial cells by platelet-activating-factor stimulation. | 1998 | Nephrol. Dial. Transplant. | pmid:9568845 |
| Snapper JR et al. | Effect of platelet-activating factor-receptor antagonism on endotoxin-induced lung dysfunction in sheep. | 1998 | J. Appl. Physiol. | pmid:9572806 |
| Cines DB et al. | Endothelial cells in physiology and in the pathophysiology of vascular disorders. | 1998 | Blood | pmid:9572988 |
| Thijs A and Thijs LG | Pathogenesis of renal failure in sepsis. | 1998 | Kidney Int. Suppl. | pmid:9573570 |
| Kitayama J et al. | The C-C chemokine receptor CCR3 participates in stimulation of eosinophil arrest on inflammatory endothelium in shear flow. | 1998 | J. Clin. Invest. | pmid:9576767 |
| Shindo K and Fukumura M | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578146 |
| Ereth MH et al. | The relation between the platelet-activated clotting test (HemoSTATUS) and blood loss after cardiopulmonary bypass. | 1998 | Anesthesiology | pmid:9579505 |
| Hüseyinov A et al. | Plasma and urinary platelet activating factor concentrations and leukotriene releasing activity of leukocytes in steroid sensitive nephrotic syndrome of childhood. | 1998 | Acta Paediatr Jpn | pmid:9583202 |
| Takasaki J et al. | Synergistic effect of type II phospholipase A2 and platelet-activating factor on Mac-1 surface expression and exocytosis of gelatinase granules in human neutrophils: evidence for the 5-lipoxygenase-dependent mechanism. | 1998 | J. Immunol. | pmid:9590257 |