| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Archer SL and Roudebush WE | Enhancement of sperm motility using pentoxifylline and platelet-activating factor. | 2013 | Methods Mol. Biol. | pmid:22992918 |
| Flasiński M et al. | Interactions between single-chained ether phospholipids and sphingomyelin in mixed monolayers at the air/water interface-Grazing incidence X-ray diffraction and Brewster angle microscopy studies. | 2013 | Colloids Surf B Biointerfaces | pmid:23777791 |
| Grotta MB et al. | Obesity increases eosinophil activity in asthmatic children and adolescents. | 2013 | BMC Pulm Med | pmid:23773659 |
| Eriksson AC and Whiss PA | Nanomolar concentrations of adrenaline induce platelet adhesion in vitro. | 2013 | Platelets | pmid:22471400 |
| Zhou Z et al. | Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity. | 2013 | Fitoterapia | pmid:23669034 |
| Wang TM et al. | Alkyl and phenolic glycosides from Saussurea stella. | 2013 | Fitoterapia | pmid:23567860 |
| Schäfer-Somi S et al. | Vascular endothelial (VEGF) and epithelial growth factor (EGF) as well as platelet-activating factor (PAF) and receptors are expressed in the early pregnant canine uterus. | 2013 | Reprod. Domest. Anim. | pmid:22458960 |
| Stanca E et al. | Down-regulation of LPCAT expression increases platelet-activating factor level in cirrhotic rat liver: potential antiinflammatory effect of silybin. | 2013 | Biochim. Biophys. Acta | pmid:23851051 |
| Nagase T | [Respiratory failure]. | 2013 | Nippon Rinsho | pmid:23855209 |
| Tao YK et al. | Elevated platelet activating factor level in ischemia-related arrhythmia and its electrophysiological effect on myocardium. | 2013 | Biomed. Environ. Sci. | pmid:23611129 |
| Vitte J and Bongrand P | Serum tryptase determination in patients with acute allergic reactions. | 2013 | J. Allergy Clin. Immunol. | pmid:23643096 |
| Vadas P | Reply: To PMID 23040367. | 2013 | J. Allergy Clin. Immunol. | pmid:23643097 |
| Vlachogianni IC et al. | Interleukin-1beta stimulates platelet-activating factor production in U-937 cells modulating both its biosynthetic and catabolic enzymes. | 2013 | Cytokine | pmid:23673285 |
| Hirayama F | Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. | 2013 | Br. J. Haematol. | pmid:23215650 |
| Harleton E et al. | Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). | 2013 | J. Biol. Chem. | pmid:23229553 |
| Detopoulou P et al. | Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. | 2013 | Curr Heart Fail Rep | pmid:23389700 |
| Wang HL et al. | Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. | 2013 | Chin J Physiol | pmid:23347011 |
| Wei JF et al. | Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. | 2013 | Biomed Res Int | pmid:23509689 |
| Forsman H et al. | Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production. | 2013 | PLoS ONE | pmid:23555913 |
| Ruchaud-Sparagano MH et al. | Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis. | 2013 | Respirology | pmid:23730995 |
| Miyamoto-Sasaki M et al. | Pitavastatin increases HDL particles functionally preserved with cholesterol efflux capacity and antioxidative actions in dyslipidemic patients. | 2013 | J. Atheroscler. Thromb. | pmid:23739642 |
| Nankar SA et al. | Differential interaction of peptides derived from C-terminal domain of human apolipoprotein E with platelet activating factor analogs. | 2013 | Biochimie | pmid:23376877 |
| Detopoulou P et al. | Baseline and 6-Week follow-up levels of PAF and activity of its metabolic enzymes in patients with heart failure and healthy volunteers--a pilot study. | 2013 | Angiology | pmid:23000600 |
| Xu B et al. | Effects of platelet-activating factor and its differential regulation by androgens and steroid hormones in prostate cancers. | 2013 | Br. J. Cancer | pmid:23949154 |
| Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
| Cui H et al. | Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. | 2013 | J. Allergy Clin. Immunol. | pmid:24021572 |
| Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
| Kim YH et al. | PAF enhances MMP-2 production in rat aortic VSMCs via a β-arrestin2-dependent ERK signaling pathway. | 2013 | J. Lipid Res. | pmid:23911909 |
| Fodran P and Minnaard AJ | Catalytic synthesis of enantiopure mixed diacylglycerols – synthesis of a major M. tuberculosis phospholipid and platelet activating factor. | 2013 | Org. Biomol. Chem. | pmid:24191360 |
| Fontbonne H et al. | Activation of bile salt dependent lipase by (lyso)phosphatidic acid and platelet activating factor. | 2013 | FEBS Lett. | pmid:23891620 |
| Feuerherm AJ et al. | Platelet-activating factor induces proliferation in differentiated keratinocytes. | 2013 | Mol. Cell. Biochem. | pmid:23975504 |
| Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
| Shi YM et al. | Lancolides, antiplatelet aggregation nortriterpenoids with tricyclo[6.3.0.0(2,11)]undecane-bridged system from Schisandra lancifolia. | 2013 | Org. Lett. | pmid:24059675 |
| Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |
| Bitencourt CS et al. | Cooperative role of endogenous leucotrienes and platelet-activating factor in ischaemia-reperfusion-mediated tissue injury. | 2013 | J. Cell. Mol. Med. | pmid:24373549 |
| Sahu RP et al. | Platelet-activating factor does not mediate UVB-induced local immune suppression. | 2012 Mar-Apr | Photochem. Photobiol. | pmid:22211638 |
| Zia-ul-Haq M et al. | Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. | 2012 Jul-Aug | Acta Pol Pharm | pmid:22876614 |
| Chini M et al. | Effects of highly active antiretroviral therapy on platelet activating factor metabolism in naive HIV-infected patients: ii) study of the abacavir/lamivudine/efavirenz HAART regimen. | 2012 Jan-Mar | Int J Immunopathol Pharmacol | pmid:22507337 |
| Chini M et al. | Effects of HAART on platelet-activating factor metabolism in naive HIV-infected patients I: study of the tenofovir-DF/emtricitabine/efavirenz HAART regimen. | 2012 | AIDS Res. Hum. Retroviruses | pmid:22050695 |
| Nordin N et al. | Platelet-activating factor (PAF) receptor binding activity of the roots of Enicosanthellum pulchrum. | 2012 | Pharm Biol | pmid:22103812 |
| Huang LG et al. | [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:22932017 |
| Pawlowic MC and Zhang K | Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence. | 2012 | Mol. Biochem. Parasitol. | pmid:22954769 |
| Nitoda E et al. | Ocular actions of platelet-activating factor: clinical implications. | 2012 | Expert Opin. Ther. Targets | pmid:22924390 |
| Sahu RP et al. | Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis. | 2012 | Carcinogenesis | pmid:22223848 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE3 on human platelet function. | 2012 | Thromb. Haemost. | pmid:22318645 |
| Xu LF et al. | Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor. | 2012 | Inflammation | pmid:21452036 |
| Gorman S and Hart PH | The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation. | 2012 | Photochem. Photobiol. Sci. | pmid:22898802 |
| Zhang XT et al. | [Study on the pharmacokinetics of ginkgolide B for injection in rats]. | 2012 | Zhong Yao Cai | pmid:22876684 |
| Saadawi S et al. | Inhibitory effects of acetylmelodorinol, chrysin and polycarpol from Mitrella kentii on prostaglandin Eâ‚‚ and Thromboxane Bâ‚‚ production and platelet activating factor receptor binding. | 2012 | Molecules | pmid:22538486 |
| Oh SF et al. | Resolvin E2 formation and impact in inflammation resolution. | 2012 | J. Immunol. | pmid:22450811 |