| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Thyroid Neoplasms | D013964 | 33 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Thalassemia | D013789 | 8 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Leukemia, Myelogenous, Chronic, BCR-ABL Positive | D015464 | 17 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Am. J. Physiol., Cell Physiol. (2)
- Arterioscler. Thromb. Vasc. Biol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yamazaki H | [Recent medical topics on platelets in hemorrhagic and thrombotic diseases]. | 1986 | Nippon Naika Gakkai Zasshi | pmid:3027214 |
| Rink TJ | Stimulus-response coupling mechanisms in human platelets. | 1986 | Agents Actions Suppl. | pmid:3028101 |
| Baroggi N et al. | Changes in cytosolic free calcium induced by platelet-activating factor in rabbit platelets: specific inhibition by BN 52021 and structurally related compounds. | 1986 | Agents Actions Suppl. | pmid:3028108 |
| Lewis RE and Granger HJ | Neutrophil-dependent mediation of microvascular permeability. | 1986 | Fed. Proc. | pmid:3510911 |
| Ramesha CS and Pickett WC | Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid. | 1986 | J. Biol. Chem. | pmid:3011789 |
| Hellewell PG and Williams TJ | A specific antagonist of platelet-activating factor suppresses oedema formation in an Arthus reaction but not oedema induced by leukocyte chemoattractants in rabbit skin. | 1986 | J. Immunol. | pmid:2940300 |
| Handley DA et al. | Inhibition and reversal of endotoxin-, aggregated IgG- and paf-induced hypotension in the rat by SRI 63-072, a paf receptor antagonist. | 1986 | Immunopharmacology | pmid:3019921 |
| Hwang SB et al. | Specific binding of [3H]dihydrokadsurenone to rabbit platelet membranes and its inhibition by the receptor agonists and antagonists of platelet-activating factor. | 1986 | J. Biol. Chem. | pmid:3020044 |
| Biftu T et al. | Conformation and activity of tetrahydrofuran lignans and analogues as specific platelet activating factor antagonists. | 1986 | J. Med. Chem. | pmid:3020247 |
| Zanetti A et al. | The effect of AD6 (8-monochloro-3-beta-diethylamino-ethyl-4-methyl-7-ethoxy- carbonylmethoxycoumarin) on washed human platelet aggregation induced by platelet activating factor (PAF) and epinephrine. | 1986 | Eur. J. Pharmacol. | pmid:2944757 |
| Bush LR and Smith SG | Antagonism of U46619-induced aggregation of human and canine platelets by four TXA2 receptor antagonists. | 1986 | Thromb. Res. | pmid:2948294 |
| Valone FH and Ruis NM | Platelet-activating factor binding to human platelet membranes. | 1986 | Biotechnol. Appl. Biochem. | pmid:3021183 |
| Braquet P | Proofs of involvement of PAF-acether in various immune disorders using BN 52021 (ginkgolide B): a powerful PAF-acether antagonist isolated from Ginkgo biloba L. | 1986 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2949548 |
| Naccache PH et al. | Biochemical events associated with the stimulation of rabbit neutrophils by platelet-activating factor. | 1986 | J. Leukoc. Biol. | pmid:3021882 |
| Panchenko EP et al. | [Free cytoplasmic calcium and thrombocyte aggregation in patients with ischemic heart disease. The effect of ADP, thrombocyte activation factor and serotonin]. | 1986 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:3801147 |
| Chamone DF et al. | Increased levels of eosinophil-derived PAF-acether activity in a patient with idiopathic hypereosinophilic syndrome. | 1986 | Braz. J. Med. Biol. Res. | pmid:3801724 |
| Toth PD and Mikulaschek AW | Effects of a platelet-activating factor antagonist, CV-3988, on different shock models in the rat. | 1986 | Circ. Shock | pmid:3802423 |
| Desquand S et al. | Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. | 1986 | Eur. J. Pharmacol. | pmid:3019727 |
| Weber N | [A platelet-activating factor--a physiologically active ether lipid]. | 1986 | Pharm Unserer Zeit | pmid:3749211 |
| Page CP et al. | Inflammatory mediators of asthma. | 1986 | Eur J Respir Dis Suppl | pmid:3527737 |
| Berti F et al. | Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives. | 1986 | Pharmacol Res Commun | pmid:3749244 |
| Mlczoch J | [Disorders of thrombocyte function and/or endothelial cell damage as a cause of primary pulmonary hypertension?]. | 1986 | Herz | pmid:3530927 |
| Burhop KE et al. | Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. | 1986 | Am. Rev. Respir. Dis. | pmid:3752711 |
| Lovett DH and Sterzel RB | Cell culture approaches to the analysis of glomerular inflammation. | 1986 | Kidney Int. | pmid:3531678 |
| Yasuda K et al. | Platelet-activating factor in normal rat uterus. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3753495 |
| Metz SA | Ether-linked lysophospholipids initiate insulin secretion. Lysophospholipids may mediate effects of phospholipase A2 activation on hormone release. | 1986 | Diabetes | pmid:3087803 |
| Daniel LW et al. | A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine. | 1986 | J. Biol. Chem. | pmid:3087989 |
| Simpson AW et al. | Low concentrations of the stable prostaglandin endoperoxide U44069 stimulate shape change in quin2-loaded platelets without a measurable increase in [Ca2+]i. | 1986 | FEBS Lett. | pmid:3086128 |
| Nakaya H and Tohse N | Electrophysiological effects of acetyl glyceryl ether phosphorylcholine on cardiac tissues: comparison with lysophosphatidylcholine and long chain acyl carnitine. | 1986 | Br. J. Pharmacol. | pmid:3814909 |
| Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
| Coëffier E et al. | Effects of PAF-acether and structural analogues on platelet activation and bronchoconstriction in guinea-pigs. | 1986 | Eur. J. Pharmacol. | pmid:3816952 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Oda M et al. | Polymorphonuclear leukocyte-platelet interactions: acetylglyceryl ether phosphocholine-induced platelet activation under stimulation with chemotactic peptide. | 1986 | J. Biochem. | pmid:3818574 |
| Nishihira J and Ishibashi T | A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. | 1986 | Lipids | pmid:3821393 |
| Lauri D et al. | Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. | 1986 | Agents Actions | pmid:3706054 |
| Nijssen JG et al. | Identification of a calcium-independent phospholipase A2 in rat lung cytosol and differentiation from acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether). | 1986 | Biochim. Biophys. Acta | pmid:3707986 |
| Fitzgerald MF et al. | The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs. | 1986 | Br. J. Pharmacol. | pmid:3708213 |
| Chand N et al. | The amplifier role of platelet activating factor (PAF), other chemical mediators and antigen in the induction of airway hyperreactivity to cold. | 1986 | Eur. J. Pharmacol. | pmid:3709669 |
| Kloprogge E et al. | Stimulus-aggregation coupling in platelets activated with PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3089297 |
| Lynch JM and Henson PM | The intracellular retention of newly synthesized platelet-activating factor. | 1986 | J. Immunol. | pmid:3093579 |
| Osborne JA et al. | In vivo anti-platelet properties of anipamil, a calcium channel blocker, in the rabbit. | 1986 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:3715198 |
| McMurtry IF and Morris KG | Platelet-activating factor causes pulmonary vasodilation in the rat. | 1986 | Am. Rev. Respir. Dis. | pmid:3094417 |
| Westwick J et al. | Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. | 1986 | Thromb. Res. | pmid:3715810 |
| Issekutz AC and Ripley M | The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. | 1986 | Am. J. Hematol. | pmid:2934975 |
| Alexandre A et al. | Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3094518 |
| Alam I and Silver MJ | Acetyltransferase activity in human platelet microsomes and washed platelets. | 1986 | Biochim. Biophys. Acta | pmid:3094588 |
| Benhamou M et al. | Decrease in IgE Fc receptor expression on mouse bone marrow-derived mast cells and inhibition of paf-acether formation and of beta-hexosaminidase release by dexamethasone. | 1986 | J. Immunol. | pmid:2935578 |
| Gillespie MN and Bowdy BD | Impact of platelet activating factor on vascular responsiveness in isolated rat lungs. | 1986 | J. Pharmacol. Exp. Ther. | pmid:3944767 |
| Viero P et al. | Thrombotic thrombocytopenic purpura and high-dose immunoglobulin treatment. | 1986 | Ann. Intern. Med. | pmid:3946966 |
| Siafaka-Kapadai A et al. | Biological activity of lipids of pine pollen on platelet aggregation in correlation with the platelet activating factor. | 1986 | Biochem. Int. | pmid:3947373 |
| McNamara PJ et al. | Autacoid binding to serum proteins. Interaction of platelet activating factor (PAF) with human serum alpha-1-acid glycoprotein (AAG). | 1986 | Biochem. Pharmacol. | pmid:3947392 |
| Morley J | Platelet activating factor and asthma. | 1986 | Agents Actions | pmid:3099555 |
| Orchard MA et al. | Basophil histamine release induced by a substance from stimulated human platelets. | 1986 | J. Immunol. | pmid:2419428 |
| Anderson RC et al. | Platelet-activating factor analogs. II. Synthesis of the 1-O-(4-decyloxymethylphenyl)- and 1-O-(4-decyloxyphenylmethyl) analogs. | 1986 | Chem. Phys. Lipids | pmid:3948294 |
| Tselepis A et al. | Effects of AGEPC on the intracellular levels of ions in Tetrahymena pyriformis. | 1986 | Biochem. Int. | pmid:3099798 |
| Hwang SB et al. | Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. | 1986 | Eur. J. Pharmacol. | pmid:3948914 |
| Doyle VM et al. | Platelet-activating factor mobilizes intracellular calcium in vascular smooth muscle cells. | 1986 | FEBS Lett. | pmid:3949010 |
| Wissner A et al. | Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety. | 1986 | J. Med. Chem. | pmid:3950913 |
| Issekutz AC and Szpejda M | Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988. | 1986 | Lab. Invest. | pmid:3951199 |
| Shukla SD | Action of phosphatidylinositol specific phospholipase C on platelets: nonlytic release of acetylcholinesterase, effect on thrombin and PAF induced aggregation. | 1986 | Life Sci. | pmid:3951330 |
| Benveniste J | Paf-acether (platelet-activating factor). | 1986 | Bull Eur Physiopathol Respir | pmid:3955269 |
| Phillips ML and Bonjouklian R | Cyclic platelet-activating factor analogues derived from 2-deoxy-D-erythro-pentose. | 1986 | Carbohydr. Res. | pmid:3955572 |
| McManus LM | Pathobiology of platelet-activating factors. | 1986 | Pathol Immunopathol Res | pmid:3543915 |
| Davis RB and Johnson MF | Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole blood. | 1986 | Thromb. Res. | pmid:3544327 |
| Patscheke H and Dierichs R | Cationized ferritin as a platelet-stimulating surface probe. Binding to platelets and effects on platelet function. | 1986 | Eur. J. Cell Biol. | pmid:3084260 |
| Billah MM et al. | Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Stimulated expression of phospholipase A2 and acetyltransferase requires differentiation. | 1986 | J. Biol. Chem. | pmid:3084473 |
| Kloprogge E et al. | Kinetics of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine-induced fibrinogen binding to human platelets. | 1986 | J. Biol. Chem. | pmid:3015954 |
| Piper PJ and Stewart AG | Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4. | 1986 | Br. J. Pharmacol. | pmid:3091131 |
| O'Flaherty JT et al. | Binding and metabolism of platelet-activating factor by human neutrophils. | 1986 | J. Clin. Invest. | pmid:3016027 |
| Hanahan DJ | Platelet activating factor: a biologically active phosphoglyceride. | 1986 | Annu. Rev. Biochem. | pmid:3017194 |
| Bette-Bobillo P et al. | Interaction between blood components and a spin-labeled analogue of PAF-acether. | 1986 | Biochim. Biophys. Acta | pmid:3017416 |
| Levesque JP et al. | Fibrinogen mitogenic effect on hemopoietic cell lines: control via receptor modulation. | 1986 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3018735 |
| Raaijmakers JA et al. | Phospholipase A2 products induce pulmonary beta-adrenoceptor deviations. | 1986 | Eur. J. Pharmacol. | pmid:3019725 |
| Ban C et al. | Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera. | 1986 | Arch. Biochem. Biophys. | pmid:3963833 |
| Cerletti C et al. | Platelet-aggregation response to single or paired aggregating stimuli after low-dose aspirin. | 1986 | N. Engl. J. Med. | pmid:3941724 |
| Bachelet M et al. | Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3092866 |
| Foegh ML et al. | Fatty acids and eicosanoids in organ transplantation. | 1986 | Prog. Lipid Res. | pmid:3321095 |
| Touvay C et al. | Proof of the involvement of platelet activating factor (paf-acether) in pulmonary complex immune systems using a specific paf-acether receptor antagonist: BN 52021. | 1986 | Prog. Lipid Res. | pmid:2827186 |
| Dewald B and Baggiolini M | Platelet-activating factor as a stimulus of exocytosis in human neutrophils. | 1986 | Biochim. Biophys. Acta | pmid:3017443 |
| Jackson CV et al. | Platelet-activating factor and the release of a platelet-derived coronary artery vasodilator substance in the canine. | 1986 | Circ. Res. | pmid:2868810 |
| Bussolino F et al. | Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. | 1986 | J. Clin. Invest. | pmid:2872233 |
| Henocq E and Vargaftig BB | Accumulation of eosinophils in response to intracutaneous PAF-acether and allergens in man. | 1986 | Lancet | pmid:2872485 |
| Cuss FM et al. | Effects of inhaled platelet activating factor on pulmonary function and bronchial responsiveness in man. | 1986 | Lancet | pmid:2873440 |
| Ostermann G et al. | Stimulation and desensitization of human and rabbit platelets by 1-O-hexadecyl-2-O-methyl-rac-glycero-3-phosphocholine and analogues. | 1986 | Thromb. Res. | pmid:3764811 |
| First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. | 1986 | Transplant. Proc. | pmid:3765055 | |
| Satoh K and Takamatsu S | [Inactivation by plasma of platelet-activating factor]. | 1986 | Nippon Ketsueki Gakkai Zasshi | pmid:3766067 |
| Gordeev KIu et al. | [Synthesis of thioanalogs of platelet activating factor (PAF)]. | 1986 | Bioorg. Khim. | pmid:3768051 |
| Hoffman DR et al. | Metabolism and function of platelet-activating factor in fetal rabbit lung development. | 1986 | Biochim. Biophys. Acta | pmid:3768390 |
| Okamoto M et al. | Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. | 1986 | Chem. Pharm. Bull. | pmid:3769104 |
| Ohga Y and Nakanishi M | Stopped-flow spectrophotometry monitoring the initial processes of platelet activation by platelet-activating factor. | 1986 | FEBS Lett. | pmid:3770190 |
| Patterson R et al. | Inhibition of rhesus monkey airway and cutaneous responses to platelet-activating factor (PAF) (AGEPC) with the anti-PAF agent SRI 63-072. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3770978 |
| Smith PF et al. | The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine. | 1986 | Immunopharmacology | pmid:3771195 |
| Andrikopoulos NK et al. | High-performance liquid chromatographic analysis of platelet activating factor on a cation-exchange column by direct ultraviolet detection. | 1986 | J. Chromatogr. | pmid:3771693 |
| Cordeiro RS et al. | Desensitization to PAF-induced rat paw oedema by repeated intraplantar injections. | 1986 | Life Sci. | pmid:3773645 |
| Hsueh W et al. | Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. | 1986 | J. Clin. Invest. | pmid:3459734 |
| Thomas Y et al. | [Synthesis of paf-acether by E. coli K12]. | 1986 | C. R. Acad. Sci. III, Sci. Vie | pmid:3101984 |
| Küster LJ and Frölich JC | Platelet aggregation and thromboxane release induced by arachidonic acid, collagen, ADP and platelet-activating factor following low dose acetylsalicylic acid in man. | 1986 | Prostaglandins | pmid:3097760 |
| Cordeiro RS et al. | Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. | 1986 | Prostaglandins | pmid:3103172 |
| Hwang SB et al. | Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. | 1986 | J. Biol. Chem. | pmid:3001070 |
| Buxton DB et al. | Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. | 1986 | J. Biol. Chem. | pmid:3001074 |