Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Steel HC et al. | Posaconazole attenuates leukotriene B4 release and uptake of calcium by chemoattractant-activated human neutrophils: a potential strategy to control neutrophil-mediated inflammation. | 2009 | J. Antimicrob. Chemother. | pmid:19744985 |
| Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
| Welch EJ et al. | Opposing effects of platelet-activating factor and lyso-platelet-activating factor on neutrophil and platelet activation. | 2009 | Mol. Pharmacol. | pmid:18931035 |
| McIntyre TM et al. | The emerging roles of PAF acetylhydrolase. | 2009 | J. Lipid Res. | pmid:18838739 |
| Liu J et al. | New vernocuminosides from the stem barks of Vernonia cumingiana Benth. | 2009 | Steroids | pmid:18840454 |
| Brooks AC et al. | Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19290950 |
| Eckels PC et al. | Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19295175 |
| Melnikova VO and Bar-Eli M | Inflammation and melanoma metastasis. | 2009 | Pigment Cell Melanoma Res | pmid:19368690 |
| Ereso AQ et al. | Lipoxin a(4) attenuates microvascular fluid leak during inflammation. | 2009 | J. Surg. Res. | pmid:19524267 |
| Giannattasio G et al. | Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis. | 2009 | Biochim. Biophys. Acta | pmid:19130898 |
| Khodoun M et al. | Peanuts can contribute to anaphylactic shock by activating complement. | 2009 | J. Allergy Clin. Immunol. | pmid:19121857 |
| Plager DA et al. | Pimecrolimus reduces eosinophil activation associated with calcium mobilization. | 2009 | Int. Arch. Allergy Immunol. | pmid:19127068 |
| Severino DN et al. | Edematogenic activity of scorpion venoms from the Buthidae family and the role of platelet-activating factor and nitric oxide in paw edema induced by Tityus venoms. | 2009 | Inflammation | pmid:19096919 |
| Mukai K et al. | New insights into the roles for basophils in acute and chronic allergy. | 2009 | Allergol Int | pmid:19153532 |
| Eigenmann PA | Mechanisms of food allergy. | 2009 | Pediatr Allergy Immunol | pmid:19154253 |
| Knezevic II et al. | Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability. | 2009 | J. Biol. Chem. | pmid:19095647 |
| Rigat B et al. | GM2 activator protein inhibits platelet activating factor signaling in rats. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486886 |
| Dutra PM et al. | Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). | 2009 | Acta Trop. | pmid:19433049 |
| Cheng L et al. | HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19389802 |
| Di Leo E et al. | Treatment of acquired cold urticaria with rupatadine. | 2009 | Allergy | pmid:19392988 |
| Chang W et al. | Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. | 2009 | Exp. Lung Res. | pmid:19415549 |
| Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
| Dorfman AL et al. | The effect of oxygen and light on the structure and function of the neonatal rat retina. | 2009 | Doc Ophthalmol | pmid:18483821 |
| Keating FK and Schneider DJ | The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro. | 2009 | J. Thromb. Thrombolysis | pmid:18574670 |
| Zhang X et al. | Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis. | 2009 | Pancreas | pmid:19657312 |
| Zhang Q et al. | Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia. | 2009 | J. Invest. Dermatol. | pmid:18580961 |
| Guo CJ et al. | The synthesis and biological evaluation of 10-O-dialkylaminoethyl ginkgolide B as platelet-activating factor antagonist. | 2008 Sep-Oct | J Asian Nat Prod Res | pmid:19003620 |
| Kurdiumov IN et al. | [Cerebrovascular and antiaggregative effects of GABA-docosahexaenoyldopamine conjugate]. | 2008 Jul-Aug | Eksp Klin Farmakol | pmid:18819437 |
| Chamogeorgakis TP et al. | Effect of N-acetyl-L-cysteine on lung ischaemia reperfusion injury in a porcine experimental model. | 2008 Jan-Feb | ANZ J Surg | pmid:18199211 |
| Kikuchi M et al. | Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | 2008 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18502110 |
| Kono N et al. | Protection against oxidative stress-induced hepatic injury by intracellular type II platelet-activating factor acetylhydrolase by metabolism of oxidized phospholipids in vivo. | 2008 | J. Biol. Chem. | pmid:18024956 |
| Schaefer MB et al. | Peroxisome proliferator-activated receptor-alpha reduces inflammation and vascular leakage in a murine model of acute lung injury. | 2008 | Eur. Respir. J. | pmid:18653653 |
| Samanta U and Bahnson BJ | Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis. | 2008 | J. Biol. Chem. | pmid:18784071 |
| Kuliszkiewicz-Janus M et al. | Platelet-activating factor changes in phospholipid extracts from the plasma, peripheral blood mononuclear cells and bone marrow mononuclear cells of patients with acute leukemia--a 31P MRS in vitro study. | 2008 | Cell. Mol. Biol. Lett. | pmid:17952375 |
| Figueiredo MB et al. | Blockades of phospholipase A(2) and platelet-activating factor receptors reduce the hemocyte phagocytosis in Rhodnius prolixus: in vitro experiments. | 2008 | J. Insect Physiol. | pmid:18036540 |
| Adamson RH et al. | Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18178724 |
| Gountopoulou A et al. | TNFalpha is a potent inducer of platelet-activating factor synthesis in adipocytes but not in preadipocytes. Differential regulation by PI3K. | 2008 | Cytokine | pmid:18180165 |
| Kwasniewski FH et al. | Small bowel injury associated to allergy is triggered by platelet-activating factor, mast cells, neutrophils and protected by nitric oxide. | 2008 | Int. Immunopharmacol. | pmid:18182253 |
| Chen Y et al. | Hepatic stellate cells may be potential effectors of platelet activating factor induced portal hypertension. | 2008 | World J. Gastroenterol. | pmid:18186558 |
| Harayama T et al. | Identification of a novel noninflammatory biosynthetic pathway of platelet-activating factor. | 2008 | J. Biol. Chem. | pmid:18285344 |
| Mizutani T et al. | Genuine functions of P-glycoprotein (ABCB1). | 2008 | Curr. Drug Metab. | pmid:18288958 |
| Fukunaga A et al. | Dermal dendritic cells, and not Langerhans cells, play an essential role in inducing an immune response. | 2008 | J. Immunol. | pmid:18292528 |
| van Zoelen MA et al. | Platelet-activating factor receptor contributes to host defense against Pseudomonas aeruginosa pneumonia but is not essential for the accompanying inflammatory and procoagulant response. | 2008 | J. Immunol. | pmid:18292561 |
| Knapp S et al. | Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptor. | 2008 | J. Immunol. | pmid:18292574 |
| Mullol J et al. | Rupatadine in allergic rhinitis and chronic urticaria. | 2008 | Allergy | pmid:18339040 |
| Su J et al. | Natural antibodies against phosphorylcholine as potential protective factors in SLE. | 2008 | Rheumatology (Oxford) | pmid:18522961 |
| McLaughlin NJ et al. | Platelet-activating factor-mediated endosome formation causes membrane translocation of p67phox and p40phox that requires recruitment and activation of p38 MAPK, Rab5a, and phosphatidylinositol 3-kinase in human neutrophils. | 2008 | J. Immunol. | pmid:18523285 |
| Felfernig M et al. | Molecular weight of hydroxyethyl starch molecules influences coagulation profile measured by thrombelastography. | 2008 | J R Nav Med Serv | pmid:18524134 |
| Tsoupras AB et al. | Anti-platelet-activating factor effects of highly active antiretroviral therapy (HAART): a new insight in the drug therapy of HIV infection? | 2008 | AIDS Res. Hum. Retroviruses | pmid:18620493 |
| Corl CM et al. | Platelet activating factor production and proinflammatory gene expression in endotoxin-challenged bovine mammary endothelial cells. | 2008 | J. Dairy Sci. | pmid:18650283 |