Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Jiang P et al. | PMS-1077, a PAF antagonist, induced differentiation of HL-60 cells with its novel activity. | 2010 | Cell Biol. Int. | pmid:20812915 |
| Renteria LS et al. | Prolonged hypoxia modulates platelet activating factor receptor-mediated responses by fetal ovine pulmonary vascular smooth muscle cells. | 2010 | Mol. Genet. Metab. | pmid:20813571 |
| Church MK | Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males. | 2010 | Br. J. Dermatol. | pmid:20819087 |
| Hasan AM et al. | Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. | 2010 | Int. Immunopharmacol. | pmid:20685403 |
| Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
| Asaka N et al. | Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets. | 2010 | Arzneimittelforschung | pmid:21117500 |
| Kordan W et al. | Effect of platelet activating factor (PAF) supplementation in semen extender on viability and ATP content of cryopreserved canine spermatozoa. | 2010 | Pol J Vet Sci | pmid:21370733 |
| Rechka A et al. | Identification of VEGF receptor-2 tyrosine phosphorylation sites involved in VEGF-mediated endothelial platelet-activating factor synthesis. | 2010 | Can. J. Physiol. Pharmacol. | pmid:20962896 |
| Soliman A et al. | Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis. | 2010 | PLoS ONE | pmid:20976181 |
| Gao F et al. | [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. | 2010 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:20979844 |
| Xu CL et al. | [Inhibitory effect of TBN on platelet aggregation in rabbit]. | 2010 | Zhong Yao Cai | pmid:21243778 |
| Garcia CC et al. | Platelet-activating factor receptor plays a role in lung injury and death caused by Influenza A in mice. | 2010 | PLoS Pathog. | pmid:21079759 |
| Zhu X et al. | Effects of ropivacaine on adhesion molecule CD11b expression and function in human neutrophils. | 2010 | Int. Immunopharmacol. | pmid:20348036 |
| Zhao D et al. | PAF exerts a direct apoptotic effect on the rat H9c2 cardiomyocytes in Ca2+-dependent manner. | 2010 | Int. J. Cardiol. | pmid:19237210 |
| Karantonis HC et al. | Platelet-activating factor involvement in thioacetamide-induced experimental liver fibrosis and cirrhosis. | 2010 | Dig. Dis. Sci. | pmid:19242794 |
| Lefebvre JS et al. | Toll-like receptor ligands induce polymorphonuclear leukocyte migration: key roles for leukotriene B4 and platelet-activating factor. | 2010 | FASEB J. | pmid:19843712 |
| Nandy D et al. | Role of AKT-glycogen synthase kinase axis in monocyte activation in human beings with and without type 2 diabetes. | 2010 | J. Cell. Mol. Med. | pmid:19754670 |
| Kida T et al. | Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. | 2010 | Exp. Eye Res. | pmid:20412793 |
| Lorrain DS et al. | Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation. | 2010 | Eur. J. Pharmacol. | pmid:20519143 |
| Chen S et al. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20367900 |
| Leoni G et al. | The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. | 2010 | Br. J. Pharmacol. | pmid:20331604 |
| Danker K et al. | Glycosidated phospholipids: uncoupling of signalling pathways at the plasma membrane. | 2010 | Br. J. Pharmacol. | pmid:20331609 |
| Kajiwara N et al. | Activation of human mast cells through the platelet-activating factor receptor. | 2010 | J. Allergy Clin. Immunol. | pmid:20392487 |
| Corl CM et al. | Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. | 2010 | Vet. Immunol. Immunopathol. | pmid:20359754 |
| Shi C et al. | H2O2 and PAF mediate Abeta1-42-induced Ca2+ dyshomeostasis that is blocked by EGb761. | 2010 | Neurochem. Int. | pmid:20362023 |
| Coy B ED et al. | The first diastereoselective synthesis of cinerins A-C, PAF-antagonistic macrophyllin-type bicyclo[3.2.1]octane neolignans, using a novel Pd-catalysed oxyarylation. | 2010 | Org. Biomol. Chem. | pmid:20401372 |
| Ritter JM | Novel targets and regulatory ordeal by QT interval. | 2010 | Br J Clin Pharmacol | pmid:20406216 |
| Donado E et al. | No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a 'thorough QT/QTc study' performed according to ICH guidelines. | 2010 | Br J Clin Pharmacol | pmid:20406224 |
| Saad MM et al. | Persistency and pathway of isoflurane-induced inhibition of superoxide production by neutrophils. | 2010 | Can J Anaesth | pmid:19882198 |
| Chen H et al. | Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease. | 2010 | Clin Oral Investig | pmid:19826843 |
| Sreevidya CS et al. | Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair. | 2010 | J. Invest. Dermatol. | pmid:19829299 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE(2) on human platelet function. | 2010 | Platelets | pmid:20433310 |
| Denizot Y | Platelet-activating factor and acute myelogenous leukemia. | 2010 | Exp. Hematol. | pmid:20303379 |
| Rieder F et al. | Inflammatory mediators in gastroesophageal reflux disease: impact on esophageal motility, fibrosis, and carcinogenesis. | 2010 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:20299604 |
| Prokosch V et al. | Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:20592227 |
| Morimoto R et al. | Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. | 2010 | J. Biol. Chem. | pmid:20663880 |
| Balestrieri ML et al. | Endothelial progenitor cells express PAF receptor and respond to PAF via Ca(2+)-dependent signaling. | 2010 | Biochim. Biophys. Acta | pmid:20637897 |
| Karasuyama H et al. | Role for basophils in systemic anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519883 |
| Sanz ML et al. | In vitro diagnosis of anaphylaxis. | 2010 | Chem Immunol Allergy | pmid:20519886 |
| Sharma J et al. | Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse. | 2010 | Biochemistry | pmid:20521843 |
| Cerkiene Z et al. | Immune factors in human embryo culture and their significance. | 2010 | Medicina (Kaunas) | pmid:20571290 |
| Adamson RH et al. | Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. | 2010 | Cardiovasc. Res. | pmid:20542878 |
| Liu SH et al. | Protection of carbon monoxide intraperitoneal administration from rat intestine injury induced by lipopolysaccharide. | 2010 | Chin. Med. J. | pmid:20497711 |
| Kuebler WM et al. | Vascular barrier regulation by PAF, ceramide, caveolae, and NO - an intricate signaling network with discrepant effects in the pulmonary and systemic vasculature. | 2010 | Cell. Physiol. Biochem. | pmid:20502002 |
| Wang L et al. | Three new compounds from Morus nigra L. | 2010 | J Asian Nat Prod Res | pmid:20552479 |
| Lu J et al. | Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. | 2010 | Pediatr. Res. | pmid:20531249 |
| Kim DD et al. | Rapamycin inhibits VEGF-induced microvascular hyperpermeability in vivo. | 2010 | Microcirculation | pmid:20163539 |
| Yost CC et al. | The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. | 2010 | Biochimie | pmid:20167241 |
| Sharif NA and Wiernas TK | Platelet-activating factor-induced intracellular signaling and release of cytokines and prostaglandin E2 in immortalized human corneal epithelial cells. | 2010 | J Ocul Pharmacol Ther | pmid:20187806 |
| Dyer KD et al. | Mouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptor. | 2010 | J. Immunol. | pmid:20421642 |
| Bate C et al. | Glycosylphosphatidylinositol anchor analogues sequester cholesterol and reduce prion formation. | 2010 | J. Biol. Chem. | pmid:20427265 |
| Shin SH et al. | Platelet-activating factor receptor mediates oxidized low density lipoprotein-induced migration of bone marrow-derived mesenchymal stem cells. | 2010 | Cell. Physiol. Biochem. | pmid:21063106 |
| Grassi G et al. | Exogenous platelet-activating factor improves the motility of human spermatozoa evaluated with C.A.S.A.: optimal concentration and incubation time. | 2010 | J. Endocrinol. Invest. | pmid:20220291 |
| Binder U et al. | The antifungal protein PAF interferes with PKC/MPK and cAMP/PKA signalling of Aspergillus nidulans. | 2010 | Mol. Microbiol. | pmid:19889092 |
| Shindou H | [Discovery and characterization of novel lysophospholipid acyltransferases]. | 2010 | Seikagaku | pmid:21348263 |
| Peng SY et al. | [Effect of ginkgolide B on the production of NO, IL-6 and RANTES from astrocytes]. | 2010 | Yao Xue Xue Bao | pmid:21351565 |
| Ciprandi G and Cirillo I | Rupatadine improves nasal symptoms, airflow and inflammation in patients with persistent allergic rhinitis: a pilot study. | 2010 Apr-Jun | J. Biol. Regul. Homeost. Agents | pmid:20487631 |
| Ploppa A et al. | Local anesthetic effects on human neutrophil priming and activation. | 2010 Jan-Feb | Reg Anesth Pain Med | pmid:20048657 |
| Michelotto PV et al. | Platelet-activating factor and evidence of oxidative stress in the bronchoalveolar fluid of Thoroughbred colts during race training. | 2010 Mar-Apr | J. Vet. Intern. Med. | pmid:20102491 |
| Ha SW and Lee CS | Differential effect of platelet activating factor on 1-methyl-4-phenylpyridinium-induced cell death through regulation of apoptosis-related protein activation. | 2010 May-Jun | Neurochem. Int. | pmid:20304020 |
| Lenshof A and Laurell T | Emerging clinical applications of microchip-based acoustophoresis. | 2011 | J Lab Autom | pmid:22093301 |
| Michelotto PV et al. | Pulmonary inflammation due to exercise-induced pulmonary haemorrhage in Thoroughbred colts during race training. | 2011 | Vet. J. | pmid:22108190 |
| Nasopoulou C et al. | Fish polar lipids retard atherosclerosis in rabbits by down-regulating PAF biosynthesis and up-regulating PAF catabolism. | 2011 | Lipids Health Dis | pmid:22087726 |
| Sánchez FA et al. | Functional significance of cytosolic endothelial nitric-oxide synthase (eNOS): regulation of hyperpermeability. | 2011 | J. Biol. Chem. | pmid:21757745 |
| Dombrowsky H et al. | Ingestion of (n-3) fatty acids augments basal and platelet activating factor-induced permeability to dextran in the rat mesenteric vascular bed. | 2011 | J. Nutr. | pmid:21775525 |
| Tsuda M et al. | Platelet-activating factor and pain. | 2011 | Biol. Pharm. Bull. | pmid:21804199 |
| Chan MV et al. | Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. | 2011 | Platelets | pmid:21806492 |
| Zhou X and He P | Temporal and spatial correlation of platelet-activating factor-induced increases in endothelial [Ca²âº]i, nitric oxide, and gap formation in intact venules. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21873500 |
| Alarcón P et al. | D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. | 2011 | Vet. Immunol. Immunopathol. | pmid:21816488 |
| Machado GB et al. | Pseudomonas aeruginosa toxin ExoU induces a PAF-dependent impairment of alveolar fibrin turnover secondary to enhanced activation of coagulation and increased expression of plasminogen activator inhibitor-1 in the course of mice pneumosepsis. | 2011 | Respir. Res. | pmid:21819560 |
| Drolet AM et al. | Platelet-activating factor induces Th17 cell differentiation. | 2011 | Mediators Inflamm. | pmid:22013287 |
| Janakiram NB et al. | Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer. | 2011 | Cancer Metastasis Rev. | pmid:22015691 |
| Verouti SN et al. | PAF effects on MCP-1 and IL-6 secretion in U-937 monocytes in comparison with oxLDL and IL-1β effects. | 2011 | Atherosclerosis | pmid:21920519 |
| Yu Y et al. | Homosecoiridoids from the flower buds of Lonicera japonica. | 2011 | J. Nat. Prod. | pmid:21942812 |
| Ajiro Y et al. | Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21949111 |
| Tsantila N et al. | In vitro and in vivo effects of statins on platelet-activating factor and its metabolism. | 2011 | Angiology | pmid:20805097 |
| Rastogi P et al. | Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | 2011 | Urology | pmid:21094990 |
| Uriarte SM et al. | Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. | 2011 | J. Immunol. | pmid:21642540 |
| Zong RK and Liu J | [Effects of Chinese herbal medicine Xinfeng Capsule on expressions of platelet-activating factor and interleukins 6 and 17 in peripheral blood of rats with adjuvant arthritis]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22152774 |
| Frelinger AL et al. | Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. | 2011 | Thromb. Haemost. | pmid:21713327 |
| Smit JJ et al. | Contribution of classic and alternative effector pathways in peanut-induced anaphylactic responses. | 2011 | PLoS ONE | pmid:22194949 |
| Parrill AL et al. | Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7. | 2011 | BMC Biochem. | pmid:22177013 |
| Xu LF et al. | Disruption of the F-actin cytoskeleton and monolayer barrier integrity induced by PAF and the protective effect of ITF on intestinal epithelium. | 2011 | Arch. Pharm. Res. | pmid:21380808 |
| Aktan I et al. | PKC isoenzymes in equine platelets and stimulus induced activation. | 2011 | Vet. Immunol. Immunopathol. | pmid:21513989 |
| Jiang W et al. | [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. | 2011 | Zhonghua Fu Chan Ke Za Zhi | pmid:22333285 |
| Kang NI et al. | Protein kinase CK2/PTEN pathway plays a key role in platelet-activating factor-mediated murine anaphylactic shock. | 2011 | J. Immunol. | pmid:21531890 |
| Tang WZ et al. | Dimeric prenylated C6-C3 compounds from the stem bark of Illicium oligandrum. | 2011 | J. Nat. Prod. | pmid:21524101 |
| Ma SG et al. | Four new phenolic diglycosides from the roots of Illicium oligandrum. | 2011 | Carbohydr. Res. | pmid:21524732 |
| Yang AP and Chen Q | [Correlation between blood-stasis tongue figure and platelet activating factor (PAF) and acetyl hydrolase of PAF (PAF-AH) in patients with primary dysmenorrhea]. | 2011 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:21485072 |
| McHowat J et al. | Platelet-activating factor and metastasis: calcium-independent phospholipase A2β deficiency protects against breast cancer metastasis to the lung. | 2011 | Am. J. Physiol., Cell Physiol. | pmid:21228317 |
| Frisardi V et al. | Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | 2011 | Prog. Lipid Res. | pmid:21703303 |
| Fang W et al. | Platelet activating factor induces blood brain barrier permeability alteration in vitro. | 2011 | J. Neuroimmunol. | pmid:20870297 |
| Fragel-Madeira L et al. | Platelet activating factor blocks interkinetic nuclear migration in retinal progenitors through an arrest of the cell cycle at the S/G2 transition. | 2011 | PLoS ONE | pmid:21298035 |
| Garland RC et al. | Noninvasive molecular imaging reveals role of PAF in leukocyte-endothelial interaction in LPS-induced ocular vascular injury. | 2011 | FASEB J. | pmid:21257713 |
| Mushtaq N et al. | Adhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matter. | 2011 | J. Allergy Clin. Immunol. | pmid:21247619 |
| Singh TP et al. | Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. | 2011 | Am. J. Pathol. | pmid:21281802 |
| Liao HJ et al. | Two new ginkgolides from the leaves of Ginkgo biloba. | 2011 | Planta Med. | pmid:21614751 |
| Penna C et al. | Platelet activating factor: the good and the bad in the ischemic/reperfused heart. | 2011 | Exp. Biol. Med. (Maywood) | pmid:21378031 |
| Brooks AC et al. | CXCL8 attenuates chemoattractant-induced equine neutrophil migration. | 2011 | Vet. Immunol. Immunopathol. | pmid:21040981 |
| Greiner C et al. | 2-(4-(Biphenyl-4-ylamino)-6-chloropyrimidin-2-ylthio)octanoic acid (HZ52)--a novel type of 5-lipoxygenase inhibitor with favourable molecular pharmacology and efficacy in vivo. | 2011 | Br. J. Pharmacol. | pmid:21506958 |