Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Osteoarthritis, Knee D020370 13 associated lipids
Polycythemia Vera D011087 13 associated lipids
Hypercalcemia D006934 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Hypertension, Portal D006975 12 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Fetal Weight D020567 12 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Death, Sudden D003645 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Amnesia D000647 12 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Infertility, Male D007248 11 associated lipids
Migraine Disorders D008881 11 associated lipids
Shock D012769 11 associated lipids
Meningioma D008579 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Shock, Septic D012772 11 associated lipids
Venous Thrombosis D020246 11 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Pancreatitis D010195 10 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Leukopenia D007970 9 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Tangier Disease D013631 8 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Thalassemia D013789 8 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Cholecystitis D002764 8 associated lipids
Arthus Reaction D001183 8 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Lupus Nephritis D008181 8 associated lipids
Behcet Syndrome D001528 7 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Mucositis D052016 7 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Mencia-Huerta JM Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. 1985 Sep-Oct Ann. Inst. Pasteur Immunol. pmid:3878684
Leslie CC and Detty DM Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. 1986 Biochem. J. pmid:3098232
Viero P et al. Defective platelet aggregation induced by platelet activating factor in myeloproliferative disorders: deficiency of an aspirin-independent mechanism? 1986 Haemostasis pmid:3699584
Etienne A et al. In vivo inhibition of plasma protein leakage and Salmonella enteritidis-induced mortality in the rat by a specific paf-acether antagonist: BN 52021. 1986 Agents Actions pmid:3515870
Oxholm P and Winther K Thrombocyte involvement in immune inflammatory reactions. 1986 Allergy pmid:3515999
Wallace JL and Whittle BJ Picomole doses of platelet-activating factor predispose the gastric mucosa to damage by topical irritants. 1986 Prostaglandins pmid:3726156
DeFeudis FV Possible relationship between the syntheses of endothelium-derived relaxing factor (EDRF) and PAF-acether. 1986 Gen. Pharmacol. pmid:3516791
Eche N et al. Platelet aggregating and procoagulant activities of cultured human breast cancer cells (FAM). 1986 Thromb. Res. pmid:3726808
Camussi G Potential role of platelet-activating factor in renal pathophysiology. 1986 Kidney Int. pmid:3517457
Hoffman DR et al. The role of platelet-activating factor in human fetal lung maturation. 1986 Am. J. Obstet. Gynecol. pmid:3728606
O'Flaherty JT Age dependency of the inflammatory response. 1986 Lab. Invest. pmid:3537520
Touvay C et al. Inhibition of antigen-induced lung anaphylaxis in the guinea-pig by BN 52021 a new specific paf-acether receptor antagonist isolated from Ginkgo biloba. 1986 Agents Actions pmid:3754380
Sybertz EJ et al. AGEPC, a vasodilator phospholipid with profound circulatory actions. 1986 Prog. Clin. Biol. Res. pmid:3538024
Sugatani J and Hanahan DJ Characterization of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (AGEPC)-induced protein phosphorylation in rabbit platelets: inhibitory effects of AGEPC analogs. 1986 Arch. Biochem. Biophys. pmid:3754710
McGowan HM et al. Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. 1986 Am. J. Physiol. pmid:3538908
Hsueh W et al. Platelet activating factor-induced ischemic bowel necrosis: the effect of PAF antagonists. 1986 Eur. J. Pharmacol. pmid:3754817
Hemmendinger S et al. [Methods of studying platelet function. Biological markers of the activation of human platelets in vivo and in vitro]. 1986 Ann. Biol. Clin. (Paris) pmid:3538949
Okamoto M et al. Platelet activating factor (PAF) involvement in endotoxin-induced thrombocytopenia in rabbits: studies with FR-900452, a specific inhibitor of PAF. 1986 Thromb. Res. pmid:3754990
Zimmerman GA and Klein-Knoeckel D Human endothelial cells inhibit granulocyte aggregation in vitro. 1986 J. Immunol. pmid:3009611
Alloatti G et al. Effect of platelet-activating factor (PAF) on human cardiac muscle. 1986 Int. Arch. Allergy Appl. Immunol. pmid:3941007
Wallace JL and Whittle BJ Prevention of endotoxin-induced gastrointestinal damage by CV-3988, an antagonist of platelet-activating factor. 1986 Eur. J. Pharmacol. pmid:3720841
Oh-ishi S et al. Suppression of phorbol myristate acetate-induced pleurisy by CV-3988, an antagonist of platelet-activating factor. 1986 Chem. Pharm. Bull. pmid:3829203
Handley DA et al. Vascular responses of platelet-activating factor in the Cebus apella primate and inhibitory profiles of antagonists SRI 63-072 and SRI 63-119. 1986 Immunopharmacology pmid:3733419
Flower RJ Background and discovery of lipocortins. 1986 Agents Actions pmid:2938452
Ramesha CS and Pickett WC Measurement of sub-picogram quantities of platelet activating factor (AGEPC) by gas chromatography/negative ion chemical ionization mass spectrometry. 1986 Biomed. Environ. Mass Spectrom. pmid:2938649
Resink TJ et al. The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. 1986 Biochem. Biophys. Res. Commun. pmid:2943273
Gay JC et al. Modulation of neutrophil oxidative responses to soluble stimuli by platelet-activating factor. 1986 Blood pmid:3006836
Stimler-Gerard NP Parasympathetic stimulation as a mechanism for platelet-activating factor-induced contractile responses in the lung. 1986 J. Pharmacol. Exp. Ther. pmid:3958964
Wade PJ et al. Effect of calcium and calcium antagonists on [3H]-Paf-acether binding to washed human platelets. 1986 Thromb. Res. pmid:3961730
Kikawa Y et al. Leukotriene B4 biosynthesis in polymorphonuclear leukocytes from blood of umbilical cord, infants, children, and adults. 1986 Pediatr. Res. pmid:3012451
Bussolino F et al. Production of platelet-activating factor by chick retina. 1986 J. Biol. Chem. pmid:3023352
Cox CP Effects of CV-3988, an antagonist of platelet-activating factor (PAF), on washed rabbit platelets. 1986 Thromb. Res. pmid:2421432
Okamoto M et al. Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives. 1986 Chem. Pharm. Bull. pmid:2421923
Darius H et al. Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. 1986 Science pmid:3082008
Kohayakawa M and Inoue K Augmentation of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF)-induced human platelet activation by C-reactive protein. 1986 Thromb. Res. pmid:3083530
Morley J et al. Effects of ketotifen upon responses to platelet activating factor: a basis for asthma prophylaxis. 1986 Ann Allergy pmid:3083731
McIntosh TK and Faden AI Thyrotropin-releasing hormone (TRH) and circulatory shock. 1986 Circ. Shock pmid:3084122
Swingle KF and Reiter MJ Inhibition of Paf-acether-induced edema of the rat's paw. 1986 Agents Actions pmid:2875631
Ghezzi E Autacoids and some mediators in allergic and non allergic forms. 1986 Boll Ist Sieroter Milan pmid:2877678
Pécoud A and Frei PC [Developmental trends in allergologic-immunologic research]. 1986 Internist (Berl) pmid:2427469
Raphael GD and Metcalfe DD Mediators of airway inflammation. 1986 Eur J Respir Dis Suppl pmid:2429857
Mehta J et al. Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. 1986 Prostaglandins Leukot Med pmid:3456620
McIntyre TM et al. Leukotrienes C4 and D4 stimulate human endothelial cells to synthesize platelet-activating factor and bind neutrophils. 1986 Proc. Natl. Acad. Sci. U.S.A. pmid:3457383
Oh S et al. Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. 1986 Prostaglandins Leukot Med pmid:3459197
Newhouse MT and Sears MR Platelet activating factor, ketotifen and asthma. 1986 N. Z. Med. J. pmid:3462569
Vilain B et al. Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021. 1986 Pharmacol Res Commun pmid:3774840
Bessin P PAF-acether and leukotriene participation in acute circulatory shock. 1986 Pharmacol Res Commun pmid:3774841
Goldstein RE et al. Coronary and pulmonary vascular effects of leukotrienes and PAF-acether. 1986 Pharmacol Res Commun pmid:3774842
Plante GE et al. Hemodynamic effects of PAF-acether. 1986 Pharmacol Res Commun pmid:3774843
Lee TC et al. A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen. 1986 J. Biol. Chem. pmid:3007498