Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Polycythemia Vera D011087 13 associated lipids
Hypercalcemia D006934 13 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Fetal Weight D020567 12 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Death, Sudden D003645 12 associated lipids
Hepatitis C, Chronic D019698 12 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Amnesia D000647 12 associated lipids
Hypertension, Portal D006975 12 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Migraine Disorders D008881 11 associated lipids
Shock D012769 11 associated lipids
Meningioma D008579 11 associated lipids
Infertility, Male D007248 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Shock, Septic D012772 11 associated lipids
Venous Thrombosis D020246 11 associated lipids
Uveitis, Anterior D014606 11 associated lipids
Rhinitis D012220 10 associated lipids
Respiratory Syncytial Virus Infections D018357 10 associated lipids
Pancreatitis D010195 10 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Renal Insufficiency, Chronic D051436 9 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Thyroiditis, Autoimmune D013967 9 associated lipids
Leukopenia D007970 9 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Tachycardia, Ventricular D017180 9 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Tangier Disease D013631 8 associated lipids
Thalassemia D013789 8 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Carcinoma, Embryonal D018236 8 associated lipids
Cholecystitis D002764 8 associated lipids
Arthus Reaction D001183 8 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Corneal Neovascularization D016510 8 associated lipids
Lupus Nephritis D008181 8 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Mucositis D052016 7 associated lipids
Bronchiectasis D001987 7 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Chen SF et al. Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers. 1994 Zhongguo Yao Li Xue Bao pmid:7801767
Li SH et al. Effects of platelet-activating factor on rat mesenteric microcirculation. 1990 Zhongguo Yao Li Xue Bao pmid:2104488
Zeng GQ and Rui YC [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. 1990 Zhongguo Yao Li Xue Bao pmid:2104489
Fu Y and Hu YM Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. 1999 Zhongguo Yao Li Xue Bao pmid:10678147
Li SH et al. Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. 1994 Zhongguo Yao Li Xue Bao pmid:7976374
Zhang M et al. Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. 1995 Zhongguo Yao Li Xue Bao pmid:7660812
Hong JL et al. [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. 1989 Zhongguo Yao Li Xue Bao pmid:2561935
Zeng GQ et al. Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. 1993 Zhongguo Yao Li Xue Bao pmid:8249627
Zhang B and Long K Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. 1993 Zhongguo Yao Li Xue Bao pmid:8249632
Zhao W et al. [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. 2010 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21038678
Di Y et al. [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. 2008 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21141514
Zhao W et al. [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. 2007 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21180114
Dong J et al. [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. 2005 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21171322
Liu SH et al. [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. 2009 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21189571
Dong JC et al. [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:10322836
Yang AP and Chen Q [Correlation between blood-stasis tongue figure and platelet activating factor (PAF) and acetyl hydrolase of PAF (PAF-AH) in patients with primary dysmenorrhea]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:21485072
Dong JC et al. [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. 1995 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8704427
Shao P et al. [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17186728
Wang J et al. [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15143716
Chen WM et al. [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12584792