Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Shaw JO et al. | Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor). | 1981 | Biochim. Biophys. Acta | pmid:7213765 |
Mencia-Huerta JM et al. | Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process? | 1981 | Agents Actions | pmid:7053072 |
Camussi G et al. | Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils. | 1981 | Immunology | pmid:6161885 |
Renooij W and Snyder F | Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues. | 1981 | Biochim. Biophys. Acta | pmid:6260215 |
Mencia-Huerta JM and Benveniste J | Platelet-activating factor (PAF-acether) and macrophages. II. Phagocytosis-associated release of PAF-acether from rat peritoneal macrophages. | 1981 | Cell. Immunol. | pmid:6260384 |
Shaw JO et al. | Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor). | 1981 | J. Immunol. | pmid:6267133 |
Slauson DO and Sanchez-Vizcaino JM | Leukocyte-dependent platelet vasoactive amine release and immune complex deposition in African swine fever. | 1981 | Vet. Pathol. | pmid:6170156 |
O'Donnell MC and Fiedel BA | Histamine secretion from human leucocytes stimulated by basophil-derived platelet-activating factor. | 1981 | Scand. J. Immunol. | pmid:6171870 |
Benveniste J | Platelet-activating factor (PAF-acether): present status. | 1981 | Agents Actions | pmid:6176101 |
Metcalfe DD et al. | The mast cell. | 1981 | Crit. Rev. Immunol. | pmid:6178551 |
Satouchi K et al. | Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation. | 1981 | J. Biol. Chem. | pmid:7217088 |
O'Flaherty JT et al. | 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. | 1981 | Am. J. Pathol. | pmid:7223864 |
Hanahan DJ et al. | Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7236259 |
Cox CP et al. | The presence of platelet-activating factor (PAF) in normal human mixed saliva. | 1981 | J. Immunol. | pmid:7240750 |
O'Donnell MC et al. | Platelet activating factor: an inhibitor of neutrophil activation? | 1981 | Clin. Exp. Immunol. | pmid:7249391 |
Findlay SR et al. | Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine. | 1981 | Am. J. Physiol. | pmid:7282914 |
Demopoulos CA et al. | Intravascular pathobiology of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF). I. Intravenous infusion in guinea pigs. | 1981 | Immunol. Lett. | pmid:7287060 |
Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
Wykle RL et al. | Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7295320 |
O'Flaherty JT et al. | Neutrophil responses to platelet-activating factor. | 1981 | Inflammation | pmid:7298160 |
Blank ML et al. | In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid. | 1981 | Life Sci. | pmid:7300575 |
Satouchi K et al. | Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets. | 1981 | Arch. Biochem. Biophys. | pmid:7305392 |
Gil MG et al. | Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306113 |
Pinckard RN et al. | Acetyl glyceryl ether phosphorylcholine: platelet-activating factor. | 1981 | Int. Arch. Allergy Appl. Immunol. | pmid:7309256 |
Czarnetzki BM and Muramatsu T | Saturated and unsaturated 1-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines derived from ratfish liver oil: effect on human leukocyte migration. | 1981 | Chem. Phys. Lipids | pmid:7318048 |
Czarnetzki BM and Benveniste J | Effect of 1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) on leukocytes I. Analysis of the in vitro migration of human neutrophils. | 1981 | Chem. Phys. Lipids | pmid:7318049 |
Bonnet J et al. | Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes. | 1981 | Agents Actions | pmid:7340441 |
Denjean A et al. | Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons. | 1981 | Agents Actions | pmid:7340444 |
O'Flaherty JT et al. | Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. | 1981 | Am. J. Pathol. | pmid:6271016 |
Lee TC et al. | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6797422 |
Vargaftig BB and Ferreira SH | Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors. | 1981 | Braz. J. Med. Biol. Res. | pmid:6802210 |
Perret BA et al. | Binding of bovine factor VIII-coated colloidal gold particles to receptors on platelet membranes. | 1981 | Agents Actions | pmid:6803540 |
Chap H et al. | Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets. | 1981 | Nature | pmid:7453828 |
Stimler NP et al. | Anaphylactic actions of platelet-activating factor. | 1981 | Am. J. Pathol. | pmid:6975043 |
Benveniste J et al. | Platelet-activating factor (PAF-acether): molecular aspects of its release and pharmacological actions. | 1981 | Int. Arch. Allergy Appl. Immunol. | pmid:7030966 |
Czarnetzki BM and Benveniste J | Effect of synthetic PAF-acether on human neutrophil function. | 1981 | Agents Actions | pmid:7041568 |
Camussi G et al. | Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: the inhibitory effect of prostacyclin (PGI2). | 1981 | Agents Actions | pmid:7041569 |
Vargaftig BB et al. | Present concepts on the mechanisms of platelet aggregation. | 1981 | Biochem. Pharmacol. | pmid:7011325 |
Colwell JA | Studies on the pathogenesis of diabetic vascular disease. | 1981 | J S C Med Assoc | pmid:7022022 |
Wintroub BU and Soter NA | Biology of the mast cell and its role in cutaneous inflammation. | 1981 | Springer Semin. Immunopathol. | pmid:7022722 |
Vargaftig BB et al. | Background and present status of research on platelet-activating factor (PAF-acether). | 1981 | Ann. N. Y. Acad. Sci. | pmid:7023317 |
Heymans F et al. | New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures. | 1981 | Biochim. Biophys. Acta | pmid:7306563 |
Karpatkin S et al. | Role of platelets in tumor cell metastases. | 1981 | Ann. N. Y. Acad. Sci. | pmid:6943955 |
Henson PM and Betz SJ | Neutrophil and platelet interactions in "allergic" and inflammatory reactions: a role for acetyl glyceryl ether phosphorylcholine (platelet-activating factor). | 1981 | Kroc Found Ser | pmid:6947075 |
Chignard M et al. | [Platelet aggregation and platelet activating factor (author's transl)]. | 1980 Oct-Dec | J Pharmacol | pmid:7206730 |
Camussi G et al. | Platelet-activating factor (PAF), a mediator of platelet aggregation. Effect of corticosteroids on PAF-induced platelet aggregation. | 1980 Oct-Dec | Minerva Nefrol | pmid:7254682 |
Suzuki K et al. | The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor. | 1980 Feb 1-15 | Thromb. Res. | pmid:6966083 |
Check WA | A new age in asthma research: study of chemical mediators. | 1980 Aug 22-29 | JAMA | pmid:6104737 |
Vargaftig BB et al. | Platelet-tissue interaction: role of platelet-activating factor (PAF-acether). | 1980 | Agents Actions | pmid:7270336 |
Vargaftig BB et al. | One, two, three or more pathways for platelet aggregation. | 1980 | Acta Med. Scand. Suppl. | pmid:6779505 |