Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Han JI et al. | RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization. | 2006 | J. Leukoc. Biol. | pmid:16565322 |
| Vahidy WH et al. | Effects of intracerebroventricular injections of free fatty acids, lysophospholipids, or platelet activating factor in a mouse model of orofacial pain. | 2006 | Exp Brain Res | pmid:16947060 |
| Purnell ET et al. | Influence of the preimplantation embryo development (Ped) gene on embryonic platelet-activating factor (PAF) levels. | 2006 | J. Assist. Reprod. Genet. | pmid:16799834 |
| Balestrieri C et al. | Relative effects of phenolic constituents from Yucca schidigera Roezl. bark on Kaposi's sarcoma cell proliferation, migration, and PAF synthesis. | 2006 | Biochem. Pharmacol. | pmid:16580641 |
| Antonopoulou S et al. | Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus. | 2006 | J Med Food | pmid:17004898 |
| Louis NA et al. | Lipid mediator networks and leukocyte transmigration. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979294 |
| Spitzer AL et al. | Early nonenhanced abdominal computed tomography can predict mortality in severe acute pancreatitis. | 2005 Sep-Oct | J. Gastrointest. Surg. | pmid:16137586 |
| Akyürek N et al. | The effect of platelet activating factor antagonist BN 52021 on bacterial translocation and ICAM-I expression in experimental obstructive jaundice. | 2005 Sep-Oct | J Invest Surg | pmid:16249168 |
| O'Neill C | The role of paf in embryo physiology. | 2005 May-Jun | Hum. Reprod. Update | pmid:15790601 |
| Krasheninnikov ME and Pliashkevich IuG | [Effects of the platelet activating factor on the proliferation and IgE secretion by U-266BL human myeloma cells]. | 2005 Jul-Aug | Eksp Klin Farmakol | pmid:16193656 |
| Marrache AM et al. | Intracellular signaling of lipid mediators via cognate nuclear G protein-coupled receptors. | 2005 Jan-Apr | Endothelium | pmid:16036317 |
| Owen JS et al. | An improved assay for platelet-activating factor using HPLC-tandem mass spectrometry. | 2005 | J. Lipid Res. | pmid:15520455 |
| Lemieux C et al. | Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. | 2005 | Blood | pmid:15498854 |
| Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
| Oku H et al. | Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. | 2005 | Planta Med. | pmid:15678383 |
| Lin P et al. | Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. | 2005 | J. Immunol. | pmid:15728511 |
| Shimada T et al. | Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms. | 2005 | J. Endocrinol. | pmid:15684346 |
| Yasu T et al. | Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules. | 2005 | Int. J. Cardiol. | pmid:15686774 |
| Fell JM | Neonatal inflammatory intestinal diseases: necrotising enterocolitis and allergic colitis. | 2005 | Early Hum. Dev. | pmid:15707723 |
| Schaloske RH et al. | Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. | 2005 | Biochim. Biophys. Acta | pmid:15708354 |
| Mann NS and Leung JW | Pathogenesis of esophageal rings in eosinophilic esophagitis. | 2005 | Med. Hypotheses | pmid:15617859 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Fulkerson PC et al. | CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. | 2005 | Blood | pmid:15802529 |
| White DC et al. | Feasibility of assessment of regulatory lipids in breath condensate as potential presymptomatic harbingers of pulmonary pathobiology. | 2005 | J. Microbiol. Methods | pmid:15963585 |
| Jeon SY et al. | Rat model of platelet-activating factor-induced rhinosinusitis. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15966528 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Lang KS et al. | Mechanisms of suicidal erythrocyte death. | 2005 | Cell. Physiol. Biochem. | pmid:15956782 |
| Kita Y et al. | A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15958190 |
| Fang YH et al. | [Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy]. | 2005 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15958323 |
| Vinson SM et al. | Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15937147 |
| Sumita C et al. | Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. | 2005 | FEBS Lett. | pmid:16004986 |
| Ou-Yang XY et al. | [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. | 2005 | Yao Xue Xue Bao | pmid:16011257 |
| Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
| Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
| Vardar S et al. | Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2005 | J. Periodontol. | pmid:15830643 |
| Rubin BB et al. | Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. | 2005 | J. Biol. Chem. | pmid:15475363 |
| Zinchuk O et al. | Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. | 2005 | Mol. Vis. | pmid:15735601 |
| Connelly PW et al. | Paraoxonase-1 does not reduce or modify oxidation of phospholipids by peroxynitrite. | 2005 | Free Radic. Biol. Med. | pmid:15607900 |
| Ivanov AI et al. | Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15576666 |
| Denizot Y et al. | Platelet-activating factor does not stimulate cAMP formation from immature forms of freshly isolated leukaemic blasts. | 2005 | Leuk. Lymphoma | pmid:15621790 |
| Tran KC et al. | Induction of angiogenesis by platelet-activating factor in the rat striatum. | 2005 | Neuroreport | pmid:16148749 |
| Milias GA et al. | Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers. | 2005 | Eur. J. Appl. Physiol. | pmid:16151835 |
| Hauser CJ et al. | Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16168959 |
| Kihara Y et al. | Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. | 2005 | J. Exp. Med. | pmid:16172262 |
| Tian X and Bazan NG | Neuroprotection by platelet-activating factor antagonism. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179552 |
| Zhang Q et al. | Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. | 2005 | J. Clin. Invest. | pmid:16184199 |
| Pexa A and Deussen A | Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16200394 |
| Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
| Hu G et al. | Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction. | 2005 | Anesth. Analg. | pmid:16243978 |
| Löhrke B et al. | Polar phospholipids from bovine endogenously oxidized low density lipoprotein interfere with follicular thecal function. | 2005 | J. Mol. Endocrinol. | pmid:16326838 |