Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Neutropenia D009503 15 associated lipids
Osteonecrosis D010020 5 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pancreatitis D010195 10 associated lipids
Parkinson Disease D010300 53 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Peritonitis D010538 38 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Pleurisy D010998 20 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Polycythemia Vera D011087 13 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Proteinuria D011507 30 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Psoriasis D011565 47 associated lipids
Pulmonary Edema D011654 23 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Rhinitis D012220 10 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Osteosarcoma D012516 50 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Seizures D012640 87 associated lipids
Shock D012769 11 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Shock, Septic D012772 11 associated lipids
Shock, Traumatic D012774 4 associated lipids
Sneezing D012912 6 associated lipids
Spasm D013035 5 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Ulcer D013276 75 associated lipids
Stomatitis D013280 14 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Tangier Disease D013631 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Wang WJ et al. [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12525061
Cheng NN and Ma YM [A hypotensive analog of platelet-activating factor (PAF) in pheretima]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8011088
Shi W et al. [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18309677
Li XG and Luo HM [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15617488
Chen ZN [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8274205
Dong JC et al. [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:10322836
Yang AP and Chen Q [Correlation between blood-stasis tongue figure and platelet activating factor (PAF) and acetyl hydrolase of PAF (PAF-AH) in patients with primary dysmenorrhea]. 2011 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:21485072
Dong JC et al. [Ginkgolides antagonizing some effects of platelet-activating factor in vitro]. 1995 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:8704427
Zhang J et al. [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. 1998 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:11475720
Shao P et al. [Research on relationship of syndrome type and parameters of hemorheology and platelet activation in patients with acute gout arthritis of dampness-heat blockage type and stasis-heat accumulate type]. 2006 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:17186728
Wang J et al. [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. 2004 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:15143716
Chen WM et al. [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. 2002 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:12584792
Zhao W et al. [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. 2010 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21038678
Di Y et al. [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. 2008 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21141514
Zhao W et al. [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. 2007 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21180114
Dong J et al. [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. 2005 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21171322
Liu SH et al. [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. 2009 Zhongguo Ying Yong Sheng Li Xue Za Zhi pmid:21189571
Yi FX and Guo ZG Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. 1998 Zhongguo Yao Li Xue Bao pmid:10375790
Ju DW et al. Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. 1994 Zhongguo Yao Li Xue Bao pmid:8010089
Sun DX et al. Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. 1993 Zhongguo Yao Li Xue Bao pmid:8503282