Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Flickinger BD and Olson MS | Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. | 1999 | Am. J. Pathol. | pmid:10329588 |
| Mori N et al. | Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. | 1999 | Am. J. Physiol. | pmid:10330250 |
| Rhee CK et al. | Effect of platelet activating factor and its antagonist on the mucociliary clearance of the eustachian tube in guinea pigs. | 1999 | Ann. Otol. Rhinol. Laryngol. | pmid:10335705 |
| Latorre E et al. | Platelet-activating factor modulates brain sphingomyelin metabolism. | 1999 | Eur. J. Biochem. | pmid:10336612 |
| Huang YH et al. | Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism. | 1999 | Clin. Exp. Immunol. | pmid:10337026 |
| Markert R and Modzelewski B | [Inflammatory mediators in the acute pancreatitis]. | 1999 | Pol. Merkur. Lekarski | pmid:10337184 |
| Alvi SA et al. | Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes. | 1999 | Mol. Hum. Reprod. | pmid:10338371 |
| Aliberti JC et al. | Platelet-activating factor induces nitric oxide synthesis in Trypanosoma cruzi-infected macrophages and mediates resistance to parasite infection in mice. | 1999 | Infect. Immun. | pmid:10338485 |
| Yoshimura T et al. | Estrogen replacement therapy decreases platelet-activating factor-acetylhydrolase activity in post-menopausal women. | 1999 | Maturitas | pmid:10340285 |
| McNulty CA et al. | Characterization of the integrin and activation steps mediating human eosinophil and neutrophil adhesion to chronically inflamed airway endothelium. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10340944 |
| Nasu K et al. | Platelet-activating factor stimulates cytokine production by human endometrial stromal cells. | 1999 | Mol. Hum. Reprod. | pmid:10341002 |
| Cepinskas G et al. | PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front. | 1999 | J. Cell. Sci. | pmid:10341212 |
| Mariano F et al. | Production of platelet-activating factor in patients with sepsis-associated acute renal failure. | 1999 | Nephrol. Dial. Transplant. | pmid:10344354 |
| Rainsford KD | Inhibition by leukotriene inhibitors, and calcium and platelet-activating factor antagonists, of acute gastric and intestinal damage in arthritic rats and in cholinomimetic-treated mice. | 1999 | J. Pharm. Pharmacol. | pmid:10344635 |
| Cruzado JM et al. | Effect of human natural xenoantibody depletion and complement inactivation on early pig kidney function. | 1999 May-Jun | Exp. Nephrol. | pmid:10352362 |
| Svetlov SI et al. | Decreased intraplatelet Ca2+ release and ATP secretion in pediatric nephrotic syndrome. | 1999 | Pediatr. Nephrol. | pmid:10353406 |
| Weber C et al. | Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions. | 1999 | Clin. Chem. Lab. Med. | pmid:10353467 |
| Del Sorbo L et al. | The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat. | 1999 | Eur. J. Immunol. | pmid:10359105 |
| Crawford SE et al. | Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds. | 1999 | J. Heart Lung Transplant. | pmid:10363692 |
| Goldman R et al. | Calcium-dependent PAF-stimulated generation of reactive oxygen species in a human keratinocyte cell line. | 1999 | Biochim. Biophys. Acta | pmid:10366777 |