Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Neutropenia D009503 15 associated lipids
Osteonecrosis D010020 5 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pancreatitis D010195 10 associated lipids
Parkinson Disease D010300 53 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Peritonitis D010538 38 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Pleurisy D010998 20 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Polycythemia Vera D011087 13 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Proteinuria D011507 30 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Psoriasis D011565 47 associated lipids
Pulmonary Edema D011654 23 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Rhinitis D012220 10 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Osteosarcoma D012516 50 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Seizures D012640 87 associated lipids
Shock D012769 11 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Shock, Septic D012772 11 associated lipids
Shock, Traumatic D012774 4 associated lipids
Sneezing D012912 6 associated lipids
Spasm D013035 5 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Ulcer D013276 75 associated lipids
Stomatitis D013280 14 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Tangier Disease D013631 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Wang LJ et al. [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. 2006 Zhongguo Dang Dai Er Ke Za Zhi pmid:16522243
Ding DD et al. [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. 2012 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:22541106
Guo NJ et al. [Activation of platelet-neutrophil mediated by platelet-activating factor]. 2005 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:15972139
Bao GQ and Ju AZ [Signal pathways of eryptosis-review]. 2009 Zhongguo Shi Yan Xue Ye Xue Za Zhi pmid:19698269
Jia XQ et al. [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. 2012 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:22464576
Shi B et al. [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. 2009 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:19695175
Chen S et al. [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. 2010 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:20367900
Hao J et al. [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552687
Chen SF et al. Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers. 1994 Zhongguo Yao Li Xue Bao pmid:7801767
Shen ZQ et al. Effect of protopine on cytosolic Ca2+ in rabbit platelets. 1999 Zhongguo Yao Li Xue Bao pmid:10452120
Li SH et al. Effects of platelet-activating factor on rat mesenteric microcirculation. 1990 Zhongguo Yao Li Xue Bao pmid:2104488
Zeng GQ and Rui YC [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. 1990 Zhongguo Yao Li Xue Bao pmid:2104489
Fu Y and Hu YM Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. 1999 Zhongguo Yao Li Xue Bao pmid:10678147
Wang XD and Bian RL [Effects of ketotifen on rabbit platelet aggregation and platelet activating factor formation from rat neutrophils]. 1990 Zhongguo Yao Li Xue Bao pmid:2130617
Sun DX et al. Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. 1992 Zhongguo Yao Li Xue Bao pmid:1333718
Ju DW et al. Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. 1994 Zhongguo Yao Li Xue Bao pmid:8010089
Qian R et al. Platelet activation by platelet aggregation factor from Eisenia foelide. 1994 Zhongguo Yao Li Xue Bao pmid:7717070
Zeng GQ et al. Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. 1993 Zhongguo Yao Li Xue Bao pmid:8249627
Zhang B and Long K Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. 1993 Zhongguo Yao Li Xue Bao pmid:8249632
Sun DX et al. Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. 1993 Zhongguo Yao Li Xue Bao pmid:8503282