Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Satouchi K et al. | Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation. | 1981 | J. Biol. Chem. | pmid:7217088 |
O'Flaherty JT et al. | 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants. | 1981 | Am. J. Pathol. | pmid:7223864 |
Satouchi K et al. | Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets. | 1981 | Arch. Biochem. Biophys. | pmid:7305392 |
Gil MG et al. | Inhibition of phospholipid methyltransferase during zymosan induced secretion of platelet-activating factor in human polymorphonuclear leukocytes. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7306113 |
Pinckard RN et al. | Acetyl glyceryl ether phosphorylcholine: platelet-activating factor. | 1981 | Int. Arch. Allergy Appl. Immunol. | pmid:7309256 |
Czarnetzki BM and Muramatsu T | Saturated and unsaturated 1-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines derived from ratfish liver oil: effect on human leukocyte migration. | 1981 | Chem. Phys. Lipids | pmid:7318048 |
Czarnetzki BM and Benveniste J | Effect of 1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) on leukocytes I. Analysis of the in vitro migration of human neutrophils. | 1981 | Chem. Phys. Lipids | pmid:7318049 |
O'Flaherty JT et al. | Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. | 1981 | Am. J. Pathol. | pmid:6271016 |
Furlan M et al. | Binding of colloidal gold granules, coated with bovine factor VIII, to human platelet membranes. | 1981 | Br. J. Haematol. | pmid:6786321 |
Colwell JA | Studies on the pathogenesis of diabetic vascular disease. | 1981 | J S C Med Assoc | pmid:7022022 |
Wintroub BU and Soter NA | Biology of the mast cell and its role in cutaneous inflammation. | 1981 | Springer Semin. Immunopathol. | pmid:7022722 |
Vargaftig BB et al. | Background and present status of research on platelet-activating factor (PAF-acether). | 1981 | Ann. N. Y. Acad. Sci. | pmid:7023317 |
Karpatkin S et al. | Role of platelets in tumor cell metastases. | 1981 | Ann. N. Y. Acad. Sci. | pmid:6943955 |
Henson PM and Betz SJ | Neutrophil and platelet interactions in "allergic" and inflammatory reactions: a role for acetyl glyceryl ether phosphorylcholine (platelet-activating factor). | 1981 | Kroc Found Ser | pmid:6947075 |
Chignard M et al. | [Platelet aggregation and platelet activating factor (author's transl)]. | 1980 Oct-Dec | J Pharmacol | pmid:7206730 |
Camussi G et al. | Platelet-activating factor (PAF), a mediator of platelet aggregation. Effect of corticosteroids on PAF-induced platelet aggregation. | 1980 Oct-Dec | Minerva Nefrol | pmid:7254682 |
Suzuki K et al. | The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor. | 1980 Feb 1-15 | Thromb. Res. | pmid:6966083 |
Check WA | A new age in asthma research: study of chemical mediators. | 1980 Aug 22-29 | JAMA | pmid:6104737 |
Clark PO et al. | Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils. | 1980 | Biochim. Biophys. Acta | pmid:7357030 |
Arnoux B et al. | Release of platelet-activating factor (PAF-acether) from alveolar macrophages by the calcium ionophore A23187 and phagocytosis. | 1980 | Eur. J. Clin. Invest. | pmid:6788561 |