Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Neutropenia D009503 15 associated lipids
Osteonecrosis D010020 5 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pancreatitis D010195 10 associated lipids
Parkinson Disease D010300 53 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Peritonitis D010538 38 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Pleurisy D010998 20 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Polycythemia Vera D011087 13 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Proteinuria D011507 30 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Psoriasis D011565 47 associated lipids
Pulmonary Edema D011654 23 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Rhinitis D012220 10 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Osteosarcoma D012516 50 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Seizures D012640 87 associated lipids
Shock D012769 11 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Shock, Septic D012772 11 associated lipids
Shock, Traumatic D012774 4 associated lipids
Sneezing D012912 6 associated lipids
Spasm D013035 5 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Ulcer D013276 75 associated lipids
Stomatitis D013280 14 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Tangier Disease D013631 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Dong JC et al. [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. 1997 Zhongguo Zhong Xi Yi Jie He Za Zhi pmid:10322836
Zang BX et al. [Inhibitory effect of kaempferol against binding of platelet activating factor to its receptor]. 2004 Zhongguo Zhong Yao Za Zhi pmid:15506296
Wang WJ et al. [Effects of musk glucoprotein on PAF production and cytosolic Ca2+ level in rat polymorphonuclear leukocytes in vitro]. 2000 Zhongguo Zhong Yao Za Zhi pmid:12525061
Cheng NN and Ma YM [A hypotensive analog of platelet-activating factor (PAF) in pheretima]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8011088
Shi W et al. [Study on composing mechanism by effect of disassembled compositions of Yiqi Huoxue decoction on platelet aggregation of health adults]. 2007 Zhongguo Zhong Yao Za Zhi pmid:18309677
Li SH et al. [Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. 1989 Zhongguo Zhong Yao Za Zhi pmid:2619897
Li XG and Luo HM [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15617488
Chen ZN et al. [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8216803
Chen ZN [Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs]. 1993 Zhongguo Zhong Yao Za Zhi pmid:8274205
Li XJ et al. [Expression of platelet-activating factor in necrotizing enterocolitis and its clinical significance]. 2011 Zhonghua Bing Li Xue Za Zhi pmid:21426810
Zhang GQ et al. [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. 2003 Zhonghua Er Ke Za Zhi pmid:14751060
Wu B et al. [Effects of bificobacterium longum on neonatal rat model of necrotizing enterocolitis and roles of platelet-activating factor and tumor necrosis factor-alpha]. 2007 Zhonghua Er Ke Za Zhi pmid:17953818
Huang LG et al. [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. 2012 Zhonghua Er Ke Za Zhi pmid:22932017
Lu H and Xue XD [Platelet-activating factor and neonatal necrotizing enterocolitis]. 2004 Zhonghua Er Ke Za Zhi pmid:15189692
Zhang S et al. [Determination of platelet activating factor and platelet associated IgG in pregnancy-induced hypertension]. 1996 Zhonghua Fu Chan Ke Za Zhi pmid:9206185
Jiang W et al. [Effects and mechanisms of platelet-activating factor on the invasiveness of ovarian cancer cells in vitro]. 2011 Zhonghua Fu Chan Ke Za Zhi pmid:22333285
Wang F et al. [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. 1997 Zhonghua Fu Chan Ke Za Zhi pmid:9596897
Tu W et al. [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. 2000 Zhonghua Jie He He Hu Xi Za Zhi pmid:11372382
Zhou X et al. [Monocellular quantitative study on the adhesive ability of eosinophils in the course of eosinophils activation]. 1996 Zhonghua Jie He He Hu Xi Za Zhi pmid:9387483
Gao F et al. [The levels of platelet-activating factor and nitric oxide synthase in bronchial asthma at high altitude]. 2010 Zhonghua Jie He He Hu Xi Za Zhi pmid:20979844