Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Neutropenia D009503 15 associated lipids
Osteonecrosis D010020 5 associated lipids
Pain D010146 64 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Pancreatitis D010195 10 associated lipids
Parkinson Disease D010300 53 associated lipids
Aggressive Periodontitis D010520 8 associated lipids
Peritonitis D010538 38 associated lipids
Platelet Storage Pool Deficiency D010981 3 associated lipids
Pleurisy D010998 20 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Pneumonia, Pneumococcal D011018 3 associated lipids
Polycythemia Vera D011087 13 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Proteinuria D011507 30 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Psoriasis D011565 47 associated lipids
Pulmonary Edema D011654 23 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Purpura, Thrombotic Thrombocytopenic D011697 6 associated lipids
Respiratory Distress Syndrome, Adult D012128 15 associated lipids
Respiratory Hypersensitivity D012130 18 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Rhinitis D012220 10 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Osteosarcoma D012516 50 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Seizures D012640 87 associated lipids
Shock D012769 11 associated lipids
Shock, Cardiogenic D012770 5 associated lipids
Shock, Septic D012772 11 associated lipids
Shock, Traumatic D012774 4 associated lipids
Sneezing D012912 6 associated lipids
Spasm D013035 5 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Staphylococcal Infections D013203 15 associated lipids
Staphylococcal Skin Infections D013207 9 associated lipids
Stomach Ulcer D013276 75 associated lipids
Stomatitis D013280 14 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Subarachnoid Hemorrhage D013345 17 associated lipids
Tangier Disease D013631 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Yan W et al. BN52021 protects rat cardiomyocyte from doxorubicin induced cardiotoxicity. 2015 Int J Clin Exp Pathol pmid:25973059
Kim YH et al. SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. 2015 Vascul. Pharmacol. pmid:25967595
Armant DR Intracellular Ca2+ signaling and preimplantation development. 2015 Adv. Exp. Med. Biol. pmid:25956298
Puebla-Osorio N et al. Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. 2015 Cell Death Dis pmid:25950475
Sahu RP et al. Systemic chemotherapy is modulated by platelet-activating factor-receptor agonists. 2015 Mediators Inflamm. pmid:25922565
Shida-Sakazume T et al. Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. 2015 PLoS ONE pmid:25803864
Laidlaw TM and Boyce JA Platelets in patients with aspirin-exacerbated respiratory disease. 2015 J. Allergy Clin. Immunol. pmid:26051947
Lautenschläger I et al. Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. 2015 PLoS ONE pmid:25793535
Jasamai M et al. Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species. 2015 Nat. Prod. Res. pmid:25332053
Huang JF et al. Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. 2015 BMC Ophthalmol pmid:25956877
Gill P et al. Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis. 2015 J. Allergy Clin. Immunol. pmid:26051949
de Oliveira MC et al. Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. 2015 J. Nutr. Biochem. pmid:26013469
Jiao D et al. Macrophages are the dominant effector cells responsible for IgG-mediated passive systemic anaphylaxis challenged by natural protein antigen in BALB/c and C57BL/6 mice. 2014 May-Jun Cell. Immunol. pmid:24751884
Concha C et al. Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. 2014 J. Vet. Sci. pmid:25013355
Mazereeuw G et al. Platelet-activating factors are associated with cognitive deficits in depressed coronary artery disease patients: a hypothesis-generating study. 2014 J Neuroinflammation pmid:24996486
Uhlig S et al. Differential regulation of lung endothelial permeability in vitro and in situ. 2014 Cell. Physiol. Biochem. pmid:24977477
Triggiani M et al. Anaphylaxis and cardiovascular diseases: a dangerous liaison. 2014 Curr Opin Allergy Clin Immunol pmid:24915548
Jin XL and O'Neill C Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. 2014 Reprod. Biol. Endocrinol. pmid:24885989
Sugatani J et al. Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. 2014 FASEB J. pmid:24100020
Fang W et al. Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain. 2014 J. Neurochem. pmid:24164378