Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Flasiński M et al. | Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level. | 2014 | J R Soc Interface | pmid:24694892 |
| Sato A et al. | C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo. | 2014 | Eur. J. Pharmacol. | pmid:25455842 |
| Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
| Papakonstantinou VD et al. | In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients. | 2014 | Lipids Health Dis | pmid:24884881 |
| Marathe GK et al. | To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase. | 2014 | J. Lipid Res. | pmid:24859738 |
| Zanatta AL et al. | Fish oil supplementation decreases oxidative stress but does not affect platelet-activating factor bioactivity in lungs of asthmatic rats. | 2014 | Lipids | pmid:24858941 |
| Mitchell MJ et al. | Fluid shear stress increases neutrophil activation via platelet-activating factor. | 2014 | Biophys. J. | pmid:24853753 |
| Carlioglu A et al. | The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. | 2014 | Arch. Gynecol. Obstet. | pmid:24840107 |
| Yu Y et al. | Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells. | 2014 | J Ovarian Res | pmid:24721622 |
| Forkel S et al. | Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. | 2014 | J. Invest. Dermatol. | pmid:24714204 |
| Fang W et al. | Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain. | 2014 | J. Neurochem. | pmid:24164378 |
| Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
| Tarui M et al. | Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. | 2014 | J. Lipid Res. | pmid:24850807 |
| Jiao D et al. | Macrophages are the dominant effector cells responsible for IgG-mediated passive systemic anaphylaxis challenged by natural protein antigen in BALB/c and C57BL/6 mice. | 2014 May-Jun | Cell. Immunol. | pmid:24751884 |
| Zelanis A et al. | Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites. | 2015 | J Proteomics | pmid:25452133 |
| Larkin EK et al. | New risk factors for adult-onset incident asthma. A nested case-control study of host antioxidant defense. | 2015 | Am. J. Respir. Crit. Care Med. | pmid:25408961 |
| Detopoulou P et al. | The relation of diet with PAF and its metabolic enzymes in healthy volunteers. | 2015 | Eur J Nutr | pmid:24639073 |
| Morita K et al. | [Pain relieving effect of platelet-activating factor (PAF) antagonists in a bone cancer pain model]. | 2015 | Nippon Yakurigaku Zasshi | pmid:26256746 |
| Plotkowski MC et al. | Contribution of the platelet activating factor signaling pathway to cerebral microcirculatory dysfunction during experimental sepsis by ExoU producing Pseudomonas aeruginosa. | 2015 | Pathog Dis | pmid:26187894 |
| Sato A et al. | Biotinylated heptapeptides substituted with a D-amino acid as platelet-activating factor inhibitors. | 2015 | Eur. J. Pharmacol. | pmid:26142829 |