Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Alarcón P et al. | D-lactic acid interferes with the effects of platelet activating factor on bovine neutrophils. | 2011 | Vet. Immunol. Immunopathol. | pmid:21816488 |
Carretta MD et al. | Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. | 2016 | Vet. Immunol. Immunopathol. | pmid:27288853 |
Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
Foster AP et al. | Platelet activating factor mimics antigen-induced cutaneous inflammatory responses in sweet itch horses. | 1995 | Vet. Immunol. Immunopathol. | pmid:7747395 |
Corl CM et al. | Lipoxygenase metabolites modulate vascular-derived platelet activating factor production following endotoxin challenge. | 2010 | Vet. Immunol. Immunopathol. | pmid:20359754 |
Strøm H and Thomsen MK | Effects of proinflammatory mediators on canine neutrophil chemotaxis and aggregation. | 1990 | Vet. Immunol. Immunopathol. | pmid:2396362 |
Larrazabal CS et al. | Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na/H exchanger 1. | 2017 | Vet. Immunol. Immunopathol. | pmid:28895869 |
Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |
Leid RW and Potter KA | Inflammation and mediators of lung injury. | 1985 | Vet. Clin. North Am. Food Anim. Pract. | pmid:3907779 |
Moore RM et al. | Effect of platelet-activating factor antagonist L-691,880 on low-flow ischemia-reperfusion injury of the large colon in horses. | 1998 Jan-Feb | Vet Surg | pmid:9449176 |
Kulikov VI and Muzia GI | [Phospholipid thrombocyte activating factor, its analogs and antagonists: prospects of their use in medicine]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801455 |
Fedorov NA | [Physiological variants of functional and biochemical indicators of thrombocytes]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1801458 |
Kaminskaia GO and Aladysheva ZhI | [Platelet activating factor and pulmonary tuberculosis]. | 1995 | Vestn. Akad. Med. Nauk SSSR | pmid:7670343 |
Strukova SM et al. | [Regulation of thrombocyte stimulating and other activities of thrombin by modulators of the recognition site]. | 1991 | Vestn. Akad. Med. Nauk SSSR | pmid:1724858 |
Shabanov VV | [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. | 2003 | Vestn. Akad. Med. Nauk SSSR | pmid:14598737 |
Hemker HC and Béguin S | The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities. | 1985 | Verh. K. Acad. Geneeskd. Belg. | pmid:4090648 |
Kim YH et al. | SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. | 2015 | Vascul. Pharmacol. | pmid:25967595 |
Marathe GK et al. | Activation of vascular cells by PAF-like lipids in oxidized LDL. | 2002 | Vascul. Pharmacol. | pmid:12449015 |
Rastogi P et al. | Urothelial cell platelet-activating factor production mediated by calcium-independent phospholipase A2γ. | 2011 | Urology | pmid:21094990 |
Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |