Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Morita E et al. | Production of 15-hydroxyeicosatetraenoic acid by purified human eosinophils and neutrophils. | 1990 | Scand. J. Immunol. | pmid:2125361 |
van der Poll T et al. | Interleukin 10 release during endotoxaemia in chimpanzees: role of platelet-activating factor and interleukin 6. | 1996 | Scand. J. Immunol. | pmid:8560191 |
O'Donnell MC and Fiedel BA | Histamine secretion from human leucocytes stimulated by basophil-derived platelet-activating factor. | 1981 | Scand. J. Immunol. | pmid:6171870 |
Morita E et al. | Differential sensitivities of purified human eosinophils and neutrophils to defined chemotaxins. | 1989 | Scand. J. Immunol. | pmid:2544988 |
Renkonen R et al. | Lymphocyte binding to and penetration through vascular endothelium is stimulated by platelet-activating factor. | 1989 | Scand. J. Immunol. | pmid:2602912 |
Hilliquin P et al. | Correlations between PAF-acether and tumor necrosis factor in rheumatoid arthritis. Influence of parenteral corticosteroids. | 1995 | Scand. J. Rheumatol. | pmid:7777830 |
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Ding Z et al. | Inhibitory effects of isoproterenol on PAF-induced endothelial cell permeability and morphological changes. | 1996 | Sci. China, C, Life Sci. | pmid:8760474 |
Ruan CG et al. | Studies on monoclonal antibodies against human platelets--a monoclonal antibody to human platelet glycoprotein I--SZ-2. | 1987 | Sci. Sin., Ser. B, Chem. Biol. Agric. Med. Earth Sci. | pmid:3659897 |
Voelkel NF et al. | Nonimmunological production of leukotrienes induced by platelet-activating factor. | 1982 | Science | pmid:7123233 |
Thurston G et al. | Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. | 1999 | Science | pmid:10617467 |
Kornecki E and Ehrlich YH | Neuroregulatory and neuropathological actions of the ether-phospholipid platelet-activating factor. | 1988 | Science | pmid:3381103 |
Abisogun AO et al. | The involvement of platelet activating factor in ovulation. | 1989 | Science | pmid:2911750 |
Darius H et al. | Role of platelet-activating factor-acether in mediating guinea pig anaphylaxis. | 1986 | Science | pmid:3082008 |
Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
Teruel MN and Meyer T | Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. | 2002 | Science | pmid:11884760 |
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Shindou H | [Lysophospholipid acyltransferase and platelet-activating factor (PAF) biosynthetic enzyme]. | 2008 | Seikagaku | pmid:18341030 |
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Satouchi K | [Platelet activating factor (PAF)--a new chemical mediator of inflammation]. | 1983 | Seikagaku | pmid:6350499 |
Shindou H | [Discovery and characterization of novel lysophospholipid acyltransferases]. | 2010 | Seikagaku | pmid:21348263 |
Moschos MM et al. | In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism. | 2017 | Semin Ophthalmol | pmid:26270771 |
Felsen D et al. | Inflammatory mediators and interstitial cystitis. | 1991 | Semin Urol | pmid:1853005 |
Moore TL and Weiss TD | Mediators of inflammation. | 1985 | Semin. Arthritis Rheum. | pmid:3936177 |
Lorant DE et al. | Platelet-activating factor mediates procoagulant activity on the surface of endothelial cells by promoting leukocyte adhesion. | 1995 | Semin. Cell Biol. | pmid:8562922 |
Murer EH | The role of platelet calcium. | 1985 | Semin. Hematol. | pmid:3901271 |
Lian EC | Pathogenesis of thrombotic thrombocytopenic purpura. | 1987 | Semin. Hematol. | pmid:3299722 |
Barnes JL and Venkatachalam MA | The role of platelets and polycationic mediators in glomerular vascular injury. | 1985 | Semin. Nephrol. | pmid:2957770 |
Fischereder M et al. | Therapeutic strategies in the prevention of acute renal failure. | 1994 | Semin. Nephrol. | pmid:8140341 |
Caplan MS et al. | The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis. | 2005 | Semin. Pediatr. Surg. | pmid:16084401 |
Frost BL and Caplan MS | Necrotizing enterocolitis: pathophysiology, platelet-activating factor, and probiotics. | 2013 | Semin. Pediatr. Surg. | pmid:23611612 |
Frost BL et al. | The importance of pro-inflammatory signaling in neonatal necrotizing enterocolitis. | 2008 | Semin. Perinatol. | pmid:18346533 |
Roudebush WE | Seminal platelet-activating factor. | 2007 | Semin. Thromb. Hemost. | pmid:17253192 |
Carveth HJ et al. | Regulation of platelet-activating factor (PAF) synthesis and PAF-mediated neutrophil adhesion to endothelial cells activated by thrombin. | 1992 | Semin. Thromb. Hemost. | pmid:1315452 |
Whatley RE et al. | Production of platelet-activating factor by endothelial cells. | 1987 | Semin. Thromb. Hemost. | pmid:3321437 |
Silvestro L et al. | Platelet-activating factor-induced endothelial cell expression of adhesion molecules and modulation of surface glycocalyx, evaluated by electron spectroscopy chemical analysis. | 1994 | Semin. Thromb. Hemost. | pmid:7527938 |
Braquet P et al. | Effect of platelet-activating factor on platelets and vascular endothelium. | 1989 | Semin. Thromb. Hemost. | pmid:2546255 |
Wang YY and Li CL | [Platelet-activating factor antagonists and asthma]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1329195 |
Liu Y and Kang GF | [Lipid mediators and liver injury]. | 1995 | Sheng Li Ke Xue Jin Zhan | pmid:8745570 |
Wu QX | [Amplification and desensitization in platelet activation]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1299958 |
Li SQ | [Platelet activating factor and cerebral ischemia]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1796263 |
Shen YZ and Li CL | [The pathophysiological role of the platelet activating factor]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1796277 |
Zeng NX | [Platelet activating factor and gastrointestinal mucosa injuries]. | 1991 | Sheng Li Ke Xue Jin Zhan | pmid:1947987 |
Chen DC | [Phosphoinositide metabolism and platelet activation]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2838899 |
Hu GL and Guo HS | [Progress in platelet-activating factor receptor research]. | 1997 | Sheng Li Ke Xue Jin Zhan | pmid:10921090 |