Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Malabsorption Syndromes D008286 16 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Thrombasthenia D013915 4 associated lipids
Gastrointestinal Hemorrhage D006471 27 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Shock, Traumatic D012774 4 associated lipids
Hemorrhagic Fever, American D006478 2 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Bronchial Hyperreactivity D016535 15 associated lipids
Arthus Reaction D001183 8 associated lipids
Thrombocytosis D013922 4 associated lipids
Toxemia D014115 3 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Klebsiella Infections D007710 7 associated lipids
Ascites D001201 25 associated lipids
Albuminuria D000419 18 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Hyperinsulinism D006946 27 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Parkinson Disease D010300 53 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Bronchial Diseases D001982 3 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Tangier Disease D013631 8 associated lipids
Heart Arrest D006323 13 associated lipids
Cystitis D003556 23 associated lipids
Cholecystitis D002764 8 associated lipids
HIV Infections D015658 20 associated lipids
Subacute Sclerosing Panencephalitis D013344 3 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
AIDS Dementia Complex D015526 4 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Medulloblastoma D008527 22 associated lipids
Zellweger Syndrome D015211 39 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Glomerulonephritis, Membranous D015433 6 associated lipids
Peripheral Vascular Diseases D016491 8 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Hypertension, Portal D006975 12 associated lipids
Atherosclerosis D050197 85 associated lipids
Leukemia-Lymphoma, Adult T-Cell D015459 25 associated lipids
Metabolic Syndrome D024821 44 associated lipids
Dyslexia D004410 3 associated lipids
Leukemia, Eosinophilic, Acute D015472 3 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Fu JM [Effects of platelet activating factor on blood platelets]. 1989 Sheng Li Ke Xue Jin Zhan pmid:2549618
Yu SQ [Effects of platelet-activating factor (PAF) and its antagonists on the male reproduction]. 1995 Sheng Li Ke Xue Jin Zhan pmid:7604226
Yin M and Fang ZY [Platelet-activating factor]. 1989 Sheng Li Ke Xue Jin Zhan pmid:2692167
Hu DH and Ma CT [Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells]. 1996 Sheng Li Xue Bao pmid:9389196
Zheng HL et al. [Role of platelet-activating factor in progesterone synthesis and vascular endothelial growth factor expression in rat luteal cells]. 2008 Sheng Li Xue Bao pmid:18425318
Tu Q and Zhang QX [Stimulation of megakaryocyte maturation and thrombopoiesis in vitro by thrombocytopoiesis-stimulating factor]. 1990 Sheng Li Xue Bao pmid:2263959
Ma CT [Variation of plasma platelet activating factor during development and reversal of hypoxic pulmonary hypertension in conscious sheep]. 1994 Sheng Li Xue Bao pmid:7973831
Du YM et al. Effects of platelet activating factor on action potentials and potassium channels in guinea-pig ventricular myocytes. 2004 Sheng Li Xue Bao pmid:15224138
Yan GT et al. [Effect of calcium overload and platelet activating factor on calcitonin gene related peptide release from lung tissue]. 1998 Sheng Li Xue Bao pmid:11324524
Jin Y et al. [The effect of autocrine factors on development of early embryos of mouse]. 2001 Shi Yan Sheng Wu Xue Bao pmid:12549014
Mathiak G et al. Platelet-activating factor (PAF) in experimental and clinical sepsis. 1997 Shock pmid:9185238
Kruse-Elliott KT et al. Role of lipid-derived mediators in tumor necrosis factor-induced endothelin-1 release in vivo. 1998 Shock pmid:9466472
Chen LW et al. Differential regulation of Ca2+ influx by fMLP and PAF in human neutrophils: possible involvement of store-operated Ca2+ channel. 2000 Shock pmid:10718373
Kruse-Elliott KT et al. Low molecular weight heparin alters porcine neutrophil responses to platelet-activating factor. 1998 Shock pmid:9744648
Kruse-Elliott KT et al. Attenuation of endotoxin-induced pathophysiology by a new potent PAF receptor antagonist. 1996 Shock pmid:8721386
Cuschieri J et al. Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. 2005 Shock pmid:15665723
Wang HG et al. The role of endogenous nitric oxide in the sympathetic and hemodynamic response to platelet activating factor-induced hypotension in anesthetized dogs. 1998 Shock pmid:9466475
Bar-Or D et al. Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. 2003 Shock pmid:12865660
Rios-Santos F et al. A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. 2003 Shock pmid:12558146
Ruggiero V et al. Beneficial effects of a novel platelet-activating factor receptor antagonist, ST 899, on endotoxin-induced shock in mice. 1994 Shock pmid:7757521
Froon AM et al. Treatment with the platelet-activating factor antagonist TCV-309 in patients with severe systemic inflammatory response syndrome: a prospective, multi-center, double-blind, randomized phase II trial. 1996 Shock pmid:9156785
Buripakdi D and Karlstad MD The role of platelet-activating factor in alterations of system A amino acid transport in rat soleus and extensor digitorum longus muscles during endotoxic shock. 1994 Shock pmid:7735984
Enzan K et al. Thromboxane rather than platelet activating factor mediates pulmonary vasoconstriction after antigen challenge in rabbits. 1996 Shock pmid:8885083
Koch T et al. Effects of stroma-free hemoglobin solutions on pulmonary vascular resistance and mediator release in the isolated perfused rabbit lung. 1994 Shock pmid:7538430
Shouji K et al. Platelet-activating factor is a key mediator of pulmonary vasoconstriction and bronchoconstriction after antigen challenge in the perfused sensitized rabbit lung. 1998 Shock pmid:9645492
Laniyonu AA et al. Endotoxin-induced microvascular leakage is prevented by a PAF antagonist and NO synthase inhibitor. 1997 Shock pmid:8989836
Albert DH et al. ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. 1996 Shock pmid:8856845
Poeze M et al. Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II trial. TCV-309 Septic Shock Study Group. 2000 Shock pmid:11049104
Karlstad MD et al. Platelet-activating factor (PAF)-induced decreases in whole-body and skeletal muscle protein synthesis. 2000 Shock pmid:11049115
James JH and Fischer JE Are the effects of platelet-activating factor on muscle metabolism of carbohydrates, amino acids and proteins attributable mainly to epinephrine? 2000 Shock pmid:11049116
Ciesla DJ et al. Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. 2000 Shock pmid:11028541
Childs EW et al. In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. 2002 Shock pmid:12412620
Gomes RN et al. Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. 2006 Shock pmid:16783197
Chen LW et al. Thermal injury-induced priming effect of neutrophil is TNF-alpha and P38 dependent. 2006 Shock pmid:16783201
Klabunde RE and Calvello C Inhibition of endotoxin-induced microvascular leakage by a platelet-activating factor antagonist and 5-lipoxygenase inhibitor. 1995 Shock pmid:8595525
Cureton EL et al. Endothelin 1 and prostacyclin attenuate increases in hydraulic permeability caused by platelet-activating factor in rats. 2010 Shock pmid:19940814
Zallen G et al. Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. 1999 Shock pmid:10030791
Granger J and Remick D Acute pancreatitis: models, markers, and mediators. 2005 Shock pmid:16374372
Bulger EM et al. The macrophage response to endotoxin requires platelet activating factor. 2002 Shock pmid:11900334
Mitsuoka H et al. Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. 2002 Shock pmid:11900339
Mariano F et al. Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. 2003 Shock pmid:12688545
Park EJ et al. Dietary ganglioside inhibits acute inflammatory signals in intestinal mucosa and blood induced by systemic inflammation of Escherichia coli lipopolysaccharide. 2007 Shock pmid:17510604
Aiboshi J et al. Blood transfusion and the two-insult model of post-injury multiple organ failure. 2001 Shock pmid:11303730
Glaser KB et al. Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. 1995 Skin Pharmacol. pmid:8688196
Baltás E et al. Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. 2003 Jul-Aug Skin Pharmacol. Appl. Skin Physiol. pmid:12784066
Wintroub BU and Soter NA Biology of the mast cell and its role in cutaneous inflammation. 1981 Springer Semin. Immunopathol. pmid:7022722
Costa M et al. Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization. 2013 Stem Cell Res pmid:23164599
Donnard M et al. Membrane and intracellular platelet-activating factor receptor expression in leukemic blasts of patients with acute myeloid and lymphoid leukemia. 2002 Stem Cells pmid:12351810
Liu J et al. New vernocuminosides from the stem barks of Vernonia cumingiana Benth. 2009 Steroids pmid:18840454
Leont'ev VK and Kankanian AP [The local activation of leukocytes and thrombocytes in periodontal diseases: the role of thrombocyte-activating factor]. 1996 Stomatologiia (Mosk) pmid:8658569