Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Sirén AL et al. | Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. | 1993 | Stroke | pmid:8506560 |
Lindsberg PJ et al. | Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. | 1990 | Stroke | pmid:2219210 |
Sirén AL et al. | Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats. | 1992 | Stroke | pmid:1440713 |
Joseph R et al. | Effect of therapy on platelet activating factor-induced aggregation in acute stroke. | 1989 | Stroke | pmid:2718200 |
Joseph R and Welch KM | Granulocytes, platelet activating factor, and stroke. | 1989 | Stroke | pmid:2756548 |
Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application. | 1999 | Stroke | pmid:10187894 |
Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application. | 1999 | Stroke | pmid:10187895 |
Bielenberg GW et al. | Infarct reduction by the platelet activating factor antagonist apafant in rats. | 1992 | Stroke | pmid:1731428 |
Joseph R et al. | Effect of ticlopidine and aspirin on platelet ionized calcium in ischemic stroke. | 1991 | Stroke | pmid:2024285 |
Kochanek PM et al. | Endogenous platelet activating factor does not modulate blood flow and metabolism in normal rat brain. | 1990 | Stroke | pmid:2309270 |
Feuerstein G et al. | Platelet-activating factor. A putative mediator in central nervous system injury? | 1990 | Stroke | pmid:2237991 |
Yoshida H et al. | Platelet-activating factor acetylhydrolase in red cell membranes. Does decreased activity impair erythrocyte deformability in ischemic stroke patients? | 1993 | Stroke | pmid:8418541 |
Nishida K and Markey SP | Platelet-activating factor in brain regions after transient ischemia in gerbils. | 1996 | Stroke | pmid:8610322 |
Wei Y et al. | Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution. | 1998 | Structure | pmid:9562561 |
Anderson BO et al. | The role of platelet activating factor and its antagonists in shock, sepsis and multiple organ failure. | 1991 | Surg Gynecol Obstet | pmid:1851337 |
Biffl WL et al. | Neutrophil apoptosis is delayed by trauma patients' plasma via a mechanism involving proinflammatory phospholipids and protein kinase C. | 2001 | Surg Infect (Larchmt) | pmid:12593704 |
Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |
Fukuoka T et al. | The platelet activating factor as a pivotal mediator of shock after liver ischemia. | 1995 | Surg. Today | pmid:7633127 |
Ono S et al. | Clinical and experimental studies on the role of platelet-activating factor (PAF) in the pathogenesis of septic DIC. | 1993 | Surg. Today | pmid:8467174 |
Abu-Zidan FM | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1998 | Surgery | pmid:9481416 |
Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
Botha AJ et al. | Postinjury neutrophil priming and activation: an early vulnerable window. | 1995 | Surgery | pmid:7638753 |
Werner J et al. | Multidrug strategies are effective in the treatment of severe experimental pancreatitis. | 2012 | Surgery | pmid:21982067 |
Biffl WL et al. | Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. | 2003 | Surgery | pmid:12874587 |
Unno N et al. | Single nucleotide polymorphism (G994-->T) in the plasma platelet-activating factor-acetylhydrolase gene is associated with graft patency of femoropopliteal bypass. | 2002 | Surgery | pmid:12110797 |
Partrick DA et al. | Nitric oxide attenuates platelet-activating factor priming for elastase release in human neutrophils via a cyclic guanosine monophosphate-dependent pathway. | 1997 | Surgery | pmid:9288123 |
Kim FJ et al. | Disparate signal transduction in neutrophil CD18 adhesion receptor expression versus superoxide generation. | 1994 | Surgery | pmid:8047994 |
Schurr MJ et al. | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1997 | Surgery | pmid:9142146 |
Takada Y et al. | Prolonged hepatic warm ischemia in non-heart-beating donors: protective effects of FK506 and a platelet activating factor antagonist in porcine liver transplantation. | 1998 | Surgery | pmid:9626320 |
Porras-Reyes BH and Mustoe TA | Platelet-activating factor: improvement in wound healing by a chemotactic factor. | 1992 | Surgery | pmid:1557687 |
Cuschieri J et al. | Platelet-activating factor priming of inflammatory cell activity requires cellular adherence. | 2002 | Surgery | pmid:12219006 |
Read RA et al. | Platelet-activating factor-induced polymorphonuclear neutrophil priming independent of CD11b adhesion. | 1993 | Surgery | pmid:8342134 |
Liu T et al. | Improved preservation of the rat liver for orthotopic liver transplantation: use of University of Wisconsin-lactobionate solution and retrograde reflushing. | 1990 | Surgery | pmid:2237771 |
Wang KS et al. | Protective effect of platelet-activating factor antagonist on ischemia-induced liver injury in rats. | 1993 | Surgery | pmid:8417492 |
Bazan NG and Allan G | Signal transduction and gene expression in the eye: a contemporary view of the pro-inflammatory, anti-inflammatory and modulatory roles of prostaglandins and other bioactive lipids. | 1997 | Surv Ophthalmol | pmid:9154273 |
Eser A et al. | Levels of thrombin-activatable fibrinolysis inhibitor and platelet-activating factor in recurrent pregnancy loss patients. | 2016 | Taiwan J Obstet Gynecol | pmid:26927250 |
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Oda M et al. | [PAF and diseases]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024019 |
Fukuda T and Makino S | [Allergy and PAF]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024020 |
Yanoshita R | [Phospholipid alteration and activation of phospholipase A2 in ischemic heart]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024024 |
Karasawa K and Nojima S | [Production and application of antibodies to PAF]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024029 |
Tsujimoto M and Hori T | [Activation of phospholipase A2 by cytokines]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:2024038 |
Ishii S and Shimizu T | [Platelet-activating factor (PAF) receptor-related pathophysiology]. | 1999 | Tanpakushitsu Kakusan Koso | pmid:10396985 |
Okiji T and Murota S | [Chemical mediators]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1901997 |
Mizoguchi H | [Erythropoietin and thrombopoietin]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1651533 |
Shindou H and Shimizu T | [New development of lysophospholipid acyltransferases]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19205351 |
Karasawa K | [Physiological role of novel metabolic pathway of platelet-activating factor(PAF): PAF-dependent transacetylation]. | 2001 | Tanpakushitsu Kakusan Koso | pmid:11193332 |
Masugi F et al. | [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. | 1982 | Tanpakushitsu Kakusan Koso | pmid:6758041 |
Terasawa M | [Platelet-activating factor (PAF) antagonists]. | 1991 | Tanpakushitsu Kakusan Koso | pmid:1850862 |
Skvortsov AA et al. | [New approaches to the study of thrombocyte aggregation in patients with dilated cardiomyopathy]. | 1989 | Ter. Arkh. | pmid:2727928 |