Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Handa RK et al. | Selective inhibition of vasoconstrictor responses by platelet-activating factor in rat kidney. | 1991 | Am. J. Physiol. | pmid:1907104 |
| Sirois MG and Edelman ER | VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. | 1997 | Am. J. Physiol. | pmid:9227554 |
| Rizzo A et al. | Platelet-activating factor increases vascular resistance in rat hindquarters by thromboxane A2. | 1995 | Am. J. Physiol. | pmid:7771545 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Haller H et al. | Endothelin increases [Ca2+]i, protein phosphorylation, and O2-. production in human alveolar macrophages. | 1991 | Am. J. Physiol. | pmid:1662920 |
| Widdicombe JH et al. | Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. | 1989 | Am. J. Physiol. | pmid:2514604 |
| Schlondorff D and Neuwirth R | Platelet-activating factor and the kidney. | 1986 | Am. J. Physiol. | pmid:3089026 |
| Sasaki T et al. | Platelet-activating factor increases platelet-dependent glycoconjugate secretion from tracheal submucosal gland. | 1989 | Am. J. Physiol. | pmid:2692465 |
| Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
| Brock TA and Gimbrone MA | Platelet activating factors alters calcium homeostasis in cultured vascular endothelial cells. | 1986 | Am. J. Physiol. | pmid:3717361 |
| Findlay SR et al. | Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine. | 1981 | Am. J. Physiol. | pmid:7282914 |
| Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
| Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
| Kinnula VL et al. | Release of reactive oxygen species by guinea pig tracheal epithelial cells in vitro. | 1992 | Am. J. Physiol. | pmid:1616055 |
| Conyers G et al. | A factor in serum lowers resistance and opens tight junctions of MDCK cells. | 1990 | Am. J. Physiol. | pmid:2221039 |
| Kvietys PR et al. | Ethanol enhances leukocyte-endothelial cell interactions in mesenteric venules. | 1990 | Am. J. Physiol. | pmid:2221068 |
| Ferrer-Lopez P et al. | Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G. | 1990 | Am. J. Physiol. | pmid:2360620 |
| Wallace JL et al. | Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. | 1989 | Am. J. Physiol. | pmid:2650567 |
| Handa RK et al. | Platelet-activating factor is a renal vasodilator in the anesthetized rat. | 1990 | Am. J. Physiol. | pmid:2360650 |
| Galens S et al. | Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. | 1995 | Am. J. Physiol. | pmid:7900832 |
| Perico N et al. | Platelet-activating factor alters glomerular barrier size selectivity for macromolecules in rats. | 1991 | Am. J. Physiol. | pmid:1713421 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Lang CH et al. | Platelet-activating factor-induced increases in glucose kinetics. | 1988 | Am. J. Physiol. | pmid:3348371 |
| Kornecki E and Ehrlich YH | Diminished responsiveness of human platelets to platelet-activating factor during pregnancy. | 1990 | Am. J. Physiol. | pmid:2396687 |
| Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
| Rabe KF et al. | Contraction of human bronchial smooth muscle caused by activated human eosinophils. | 1994 | Am. J. Physiol. | pmid:7943259 |
| Dobrowsky RT et al. | Effect of SRI 63-675 on hemodynamics and blood PAF levels during porcine endotoxemia. | 1991 | Am. J. Physiol. | pmid:2035668 |
| Kubes P et al. | Platelet-activating factor-induced microvascular dysfunction: role of adherent leukocytes. | 1990 | Am. J. Physiol. | pmid:2301577 |
| Chang SW et al. | Beneficial effect of a platelet-activating factor antagonist, WEB 2086, on endotoxin-induced lung injury. | 1990 | Am. J. Physiol. | pmid:2301603 |
| Pique JM et al. | Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF. | 1990 | Am. J. Physiol. | pmid:2316650 |
| Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
| Montrucchio G et al. | Potential angiogenic role of platelet-activating factor in human breast cancer. | 1998 | Am. J. Pathol. | pmid:9811351 |
| O'Flaherty JT et al. | Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents. | 1981 | Am. J. Pathol. | pmid:6274199 |
| Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
| Lehr HA et al. | In vitro effects of oxidized low density lipoprotein on CD11b/CD18 and L-selectin presentation on neutrophils and monocytes with relevance for the in vivo situation. | 1995 | Am. J. Pathol. | pmid:7531948 |
| Byrne SN et al. | The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. | 2011 | Am. J. Pathol. | pmid:21703403 |
| Montrucchio G et al. | Nitric oxide mediates angiogenesis induced in vivo by platelet-activating factor and tumor necrosis factor-alpha. | 1997 | Am. J. Pathol. | pmid:9250168 |
| Zhou WG et al. | Evidence for platelet-activating factor as a late-phase mediator of chronic pancreatitis in the rat. | 1990 | Am. J. Pathol. | pmid:1701964 |
| Montrucchio G et al. | Role of platelet-activating factor in the reperfusion injury of rabbit ischemic heart. | 1990 | Am. J. Pathol. | pmid:2372044 |
| Singh TP et al. | Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. | 2011 | Am. J. Pathol. | pmid:21281802 |
| Koyama S et al. | Bradykinin stimulates type II alveolar cells to release neutrophil and monocyte chemotactic activity and inflammatory cytokines. | 1998 | Am. J. Pathol. | pmid:9846978 |
| Warren JS | Relationship between interleukin-1 beta and platelet-activating factor in the pathogenesis of acute immune complex alveolitis in the rat. | 1992 | Am. J. Pathol. | pmid:1519663 |
| Flickinger BD and Olson MS | Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. | 1999 | Am. J. Pathol. | pmid:10329588 |
| Sun XM et al. | Effects of in vivo 'priming' on endotoxin-induced hypotension and tissue injury. The role of PAF and tumor necrosis factor. | 1990 | Am. J. Pathol. | pmid:2327475 |
| Montrucchio G et al. | Role of platelet-activating factor in polymorphonuclear neutrophil recruitment in reperfused ischemic rabbit heart. | 1993 | Am. J. Pathol. | pmid:8434642 |
| Hsueh W et al. | Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis. | 1986 | Am. J. Pathol. | pmid:3080895 |
| Bussolati B et al. | Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. | 1999 | Am. J. Pathol. | pmid:10027419 |
| Zhou W et al. | Role of platelet-activating factor in pancreatitis-associated acute lung injury in the rat. | 1992 | Am. J. Pathol. | pmid:1562055 |
| Zhou W et al. | Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. | 1993 | Am. J. Pathol. | pmid:8494049 |
| Humphrey DM | Inflammatory exudates in skin windows induced by 1-0-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine. | 1990 | Am. J. Pathol. | pmid:2407127 |